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This comic references the pattern for US telephone numbers, which are ten digits in length. In the early days of the mobile era, the geography-based numbering still applied to new mobile lines, so mobile phones would have the same area code as owners' home numbers. In the explanation: "The next three digits are the exchange number (the middle digit being always 2 or higher)". I guess this has something to do with keeping your phone number even when switching providers? One reason for switching to a new "local" number would be so that those who have land lines aren't making "long-distance" phone calls to your cell phone.
For anyone from outside the US, the key fact here is that in the US, your mobile phone has an area code the same as a landline.
In the US, our cars kind of do have a postal address -- the state they are titled & registered in, the same state emblazoned on the license plate in the back (and sometimes the front also). If you have an out-of-country car, and move to Italy for more than a year, then you have to get Italian license plates. In the UK the first two letters on a car's plate are for where it was registered, but after that they may as well be meaningless, you do see more S plates in Scotland, M plates in Manchester etc. On the subject of postal addresses, I had an Irish friend at uni, and when we were exchanging addresses to write to each other at the end of first year he gave his address as (not his real name, obviously) Sean Murphy, Kilbeggan, Ireland. Caernarfonshire, for example, had JC and CC and the code was in bare metal on a black background. But we write it "Handy" ("Handi" (with a german "i") is how you speak it – the letter "y" can be a "i"- or a "u"-sound in German). There is a lot of information about the structure of US phone numbers here, and while general information is good to set up the joke, the specifics can be left to the wikipedia article. I trimmed a lot of unnecessary information from the explanation, because it had nothing to do with explaining the joke of the comic.
The middle digit of the area code was originally always 0 or 1 to allow mechanical dialing circuits to identify the sequence as an area code or not. The next three digits are the exchange number (the middle digit being always 2 or higher), and the final four digits are typically random. Business customers frequently could pay a premium for a specific number (if available), either to spell a brief slogan, or for easy memorization. The prevalence of digitally controlled dialing allowed the restrictions on digits in area codes and exchanges to be relaxed, suddenly making many new area codes and exchanges available.
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I ran a Schol Bio tutorial out at the uni yesterday & the last exercise we did involved going over a question from last year's paper. In sickle-cell the substitution is replacing an amino acid with an acidic r-group with another amino acid with a hydrophobic r-group. Here is a recent press release discussing current and possible future treatments of sickle cell anemia.
I love Bella Thorne so much , she is an great actress singer and dancer and she is a great role model for a lot of people. That’s why we have came up with a system to prevent spammers from leaking the numbers and annoying celebrities. As someone who struggles every day with the torment of anxiety, calling Bella was the best thing happening to me . I had such a fun time calling Bella Thorne because I love her in the disney show Shake It Up , she’s cute and caring , thank you. All you have to do is signup with Tollfreenumber.ORG and we will give you your own 1(800) toll free phone number.
Now we are proud to offer 1-800 cell phone numbers, to add to our extensive list of toll free features and services. The toll-free number is piggybacked on top of your current cell phone number, so you can continue to use both your Cell phone number and your new toll-free number.
It absolutely will NOT affect your cell phone contract, and you can even pick your own unique vanity number (which you will still own for life!). This new toll free cell phone service works on all phones including old phones, and smartphones like Andriod, Iphone 4 4s and iPhone 5.
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The toll free cell phone numbers can even work on multiple cell phones simultaneously, as it uses call forwarding to call up to five phone numbers in a row trying to find you, so that you won’t have to miss out on any important calls.
Includes voicemail and a Virtual office, so that your calls can be answered and routed based on numbers entered into the keypad or forwarded by extension. There are a variety of reasons why choosing a 1-800 cell phone number is often an ideal solution for boosting business and enhancing your marketing efforts. While traditional toll free numbers may require that you are in-office in order to take the call, cell phone toll free numbers give you the freedom to take calls while at home or on the go. Businesses that are mobile may find that a cell phone toll free number is the only option that gives them the power to achieve all of the benefits commonly associated with a toll free number while not having to rely on an answering service or hiring additional staff to take the calls. For all of these reasons and many more, 1-800 cell phone numbers are considered to be the “next big thing” in the toll free industry, and individuals and businesses alike are registering their toll free cell phone numbers at record rates.
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In the future, people who got to pick cool numbers by signing up for Google Voice early will be revered as wizards. Unlike in other countries, there is no quick way to determine whether that number is for a land-line or mobile customer. Late in 2003, US telephone service providers were required to support "number portability", meaning that customers could theoretically take their mobile phone number with them to a new provider, even when moving to a distant new location. Upon signing up, users can choose any available new 10-digit number without regard to geographic area.
We got a law in Norway around that time, which says you're able to keep your phone number while switching. My brother just recently moved back from the east coast and is keeping his same cell phone number, which doesn't affect my other siblings and myself because we only use cell phones (which only count the number of minutes used). Back in the day (before the early 2000s), many people still had a land line as their primary or only phone. I used to live in the US, and it blew my mind to learn that mobile phones had area codes there. It requires states to give "full faith and credit" to the public acts, records, and court proceedings of the other states. Now, if you move, you pay car taxes to a different province, but your license plate stays the same. Car numbers changed a couple of times when they had to add a number because of having used up all the earlier ones. They changed that at the same time to black code on a reflective white background front (and yellow back. This is a literal definition and as such shouldn't fall victim to confusion about regional terminology like "cell". Specifically, all the talk of how exchanges are numbered and long distance charges is utterly irrelevant to the strip, and the information about choosing custom numbers is relevant only to the title text (and takes about one line to explain). Explain xkcd uses ads to pay for bandwidth, and we manually approve all our advertisers, and our ads are restricted to unobtrusive images and slow animated GIFs.
This means that you can you register for a toll free cell phone number without spending a fortune that other service providers may charge, so that you can still receive all of the benefits of a toll free number for your business. Our superior customer service and low rates have made us the leading name in the toll free industry.
In either case, the first three digits are referred to as the "area code", a term dating back to before the proliferation of mobile phones, when specific codes were assigned to geographic regions.
In the early days this wasn't always very easy to do, but became commonplace within a couple years. Among other things, this allows the earlier users to choose "cool numbers" if desired, such as ones that correspond to phonewords or have a pleasing pattern. Only difference is that here you can only tell, from the first two of eight digits, which provider you had in 2005 (or whenever it took effect).
But my mom still uses land lines most of the time and so she's being billed for a long-distance call whenever she calls him, even though he lives about a mile away from her.
Unless I misremember.) One thing I do know for sure is that I used Google news before it was clickbait.

Let me know if you're aware of an audience that would not understand "mobile", or just add the appropriate clarification yourself. The meat of the joke is that area codes used to be location-based but rapidly became more flexible around 2005, resulting in that rather arbitrary meaning today, yet this is mentioned almost casually in just one sentence near the end.
If you look at most of the explanations past the 1050 mark, quite a few of them aren't perfect. The mutant molecule differs in just one amino acid from the normal one, but this is enough for it to have significant health effects.
In order for you to see this page as it is meant to appear, we ask that you please re-enable your Javascript! Anyone who wants to unlock the phone number must complete a survey to prove that they are a human and not a spam robot. The next three digits had some rules based on the telephone exchange but as Randall says, those and the final four numbers are essentially meaningless. Since most users opt to keep their numbers constant whenever possible, numbers generally stopped changing after about 2005, instead of shifting when people moved like they were forced to in previous years.
In the past, this "vanity numbering" was typically only available to businesses via toll-free numbers.
But since most people are ditching the land lines, I think it'll be a moot point in about 5-10 years.
If you moved to a new area, you would get a new phone number, and if you moved out of the previous area code, a new area code. I will trim and reorder the article so that it's more relevant to the comic shortly, unless there are objections.
When red blood cells containing the mutant form of haemoglobin are placed in a low oxygen environment, then they collapse into a rigid, jagged, sickle shape that clogs capillaries.
If you look at a map showing the distribution of malaria, and compare that with one showing the frequency of the sickle-cell allele in various populations, you'll see a considerable degree of overlap: the highest frequencies of Hbs coincide with areas where malaria is endemic. You don’t get a chance to personally speak to your favorite singer Bella Thorne everyday, do you? Therefore, examination of a given phone number will likely tell you where its owner was living at that time, since their number would not have changed after 2005 due to the portability law. Some mobile service providers began allowing similar customization after the portability law, but often still restricted new numbers by area code, keeping the availability of "cool numbers" low until Google Voice launched. This in turn has a range of physical effects on organ systems throughout the body - this is an example of pleiotropy. I can assure you she’s really awesome, and you will love it immediately. We worked a lot to get her number so please be carefull. This was especially true after the 2003 law made it so you could keep the same number even if you switch your provider.
Download link at the top just click on Download Number , we’ve also added some pictures with proof below. The year 2005 has to do with when many people made their cell phone their primary or only phone.
As this USA TODAYarticle mentions, in 2003 18% of Americans with cell phones considered their cell phone their primary phone.
Given the rapid growth of the industry, it is possible that 2005 is when more than half of cell phone owners in America considered their cell phone their primary phone. And someone with the Hbs allele would most likely have had at least one parent heterozygous for this allele.
Why? Because individuals with full-blown SCD (ie homozygous recessive) are very unlikely to survive to reproduce. Where malaria is endemic, people who are heterozygotes for Hbs have a certain degree of protection against the parasite, because Plasmodium can't get into their sickled red blood cells. However, in countries like NZ there is no selective advantage in carrying the mutant allele, & in fact that 1% frequency here is probably due (at least in part) to immigration.
In addition, modern medical care can reduce the health impacts for carriers and can also allow individuals with full SCD to survive, and this will also help to maintain the sickle-cell allele in the population. But in the end the group decided that biotechnological applications don't offer any prospect of a cure at present. For example, while it's perfectly possible to test adults, embryos or zygotes for the allele, and this gives choices about reproduction & so may reduce the number of affected individuals in the future, this is not a cure. And you could potentially  use bone marrow (stem cell) treatments for affected individuals, but this would not stop the allele being passed on to any offspring - you'd have to do the treatment all over again.

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