This phenomenon has been shown in test tube laboratory experiments, but now researchers at the University of North Carolina School of Medicine have demonstrated that the same phenomenon occurs in a humanized mouse model, suggesting a promising new target for tackling the virus, which has killed nearly 30 million people worldwide since it first appeared three decades ago. A family of human proteins called APOBEC3 effectively restrict the growth of HIV and other viruses, but this action is fully counteracted by the viral infectivity factor gene (vif) in HIV. For the current study, Garcia and his colleagues also infected BLT mice with another, highly harmful strain of the virus. In addition to Garcia and Krisko, other study authors are Francisco Martinez-Torres, PhD, and John L. Candler Professor Bali Pulendran’s research on the immune response has helped identify how individual immune cells produce specific responses to HIV. HIV consists of just two strands of genetic material together with a small number of enzymes wrapped inside a viral envelope.
If nothing else, after three decades of studying HIV, we know that it can perform that task with remarkable efficiency—fusing to lymphocytes and other protective cells in the body, injecting its viral core into them, and assembling thousands of new viral cores that deploy and destroy the human immune system. Despite a wealth of information about HIV, we still don't know how to develop an effective protective vaccine against it, in part because the outer envelope is able to mutate in ways that are different in each infected person. While it's most commonly caught by having unprotected sex - sex without a condom - as it's found in semen, vaginal and anal fluids, blood, and even breast milk. To start replicating in our immune systems cd4 cells virus must first enter our blood stream.
Let us first have a look at the basic structure of HIV Virus, and understand the importance of some of the parts of virus. Human Immunodeficiency Virus (HIV) is divided into two main groups HIV-1 and HIV-2, it is closely related to SIV (Simian Immunodeficiency Virus) found in chimpanzee and monkeys found in Africa, HIV is believed to have come to human in a process called species jumping,  There are several sub-types of HIV-1 and HIV-2 where as HIV-2 is more closely related to SIV and not only is found much less, it is also less infective and much rarely progresses to AIDS. HIV pandemics has been mainly caused HIV-1 and its sub-strain Group M (group Major), it is found in more than 90% of all HIV cases around the globe. Though these cases of AIDS were reported first in 1981 which eventually led to the finding of HIV virus, but with modern knowledge of HIV we know that these disease are found in patients of AIDS which is essentially the late stage of HIV infection, as we know today that most people remain in clinical latency stage for 8-10 years after contacting HIV, so it is pretty safe to say that the epidemics of HIV started in united states much earlier and most probably in early 1970s.
Most people unknowingly contact HIV infection either by unprotected sex or by coming in contact to HIV infected blood eg. Kindly remember that these very early HIV symptoms may come in some people as early as after 2 weeks and for many after 3 months or even later, and not all people have these early symptoms of HIV, large number of people in fact never have them. These symptoms could last for days to several weeks, and then slowly immune system starts becoming stronger and disease progresses to second stage. HIV CANNOT BY TRANSMITTED BY: Touching HIV positive person, sharing toilets, sharing utensils, through swimming pools, kissing, handshake, mosquito or insect bite.


Kissing: HIV cannot by transmitted by kissing as saliva contains very small quantity of HIV virus, risk is negligible unless both kissing partners have sores or ulcer or bleeding gums in mouth. Insect bite: HIV infection is not transmitted by insect bite such as mosquito bite as mosquito don't inject blood into you while biting. Sterile Needles: HIV cannot be transmitted through sterile needles, never use non-sterile needles, preferable always use disposable needles. HIV infected:  There are large number of people living with HIV who are not aware of the fact that they are infected, especially this is true for developing nations and even more true for countries like India, where health sector is dominated by private sector, and very few people get themselves tested for HIV, Large number of Indians discover about their status only when disease is already in the advance stage.
HIV diagnosed: HIV diagnosed person needs counseling and education regarding the disease, HIV is not acutely fatal disease, hence patient education plays vital role in long term survival of the HIV infected person. HIV care and follow-up: once diagnosed with HIV, person should have regular check-up for his or her disease condition, especially critical is to monitor the immune status and number of virus in the person’s blood, this is done through CD4 count test and HIV viral load test, based on the results of this test it is decided when to start the anti-retroviral therapy, HIV infective person who have high cd4 count and low viral load may still have many health problems due to defects created in immune system by the HIV virus, hence these health problems may need treatment from time to time.
HIV therapy: once person’s immune system reaches the critical level, anti retroviral therapy is started to stop the multiplication of virus. HIV undetectable: with modern therapy if initiated at right time and person adheres well to the therapy there are real chance of achieving undetectable level of HIV virus in blood for long time or even for decades. The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. The aptly named “BLT” mouse is created by introducing human bone marrow, liver and thymus tissues into animals without an immune system of their own. The results show that this strain of HIV does continue to replicate, even without vif, but at a much slower rate and without harming the human immune system.
Foster, PhD, all of the Center for AIDS Research at the University of North Carolina School of Medicine. Hence virus is always looking the ways to enter the living cells, but they cannot enter just any cell and replicate, they can replicate only in some specific cells, this ability to replicate only in certain cells is called tropism. Followed by group P, all other sub-strains are found rarely, Where as HIV-2 is mainly limited to some parts of Africa.
Modern studies indicate that that this infection originated in Africa, so in Africa it would have become epidemic even much earlier, but due to poverty, wilderness in the continent and its poor connectivity to rest of the world for long time, kept that infection isolated. All content, including text, graphics, images and information, contained on or available through this web site is for general information purposes only.
When this gene is removed from the virus, the innate human immune system destroys HIV by mutating it to the point where it can no longer survive. They found that the most commonly transmitted strains of HIV are completely neutralized by APOBEC3 proteins when vif is removed from the virus.


The mice have a fully functioning human immune system and can be infected with HIV in the same manner as humans.
Further, the researchers found that virus replication in this case was limited to one tissue—the thymus—in the entire body. Expert Profile: Eric HunterGuido Silvestri studies how simian immunodeficiency virus (SIV, a close-cousin of HIV) causes disease in some non-human primates and not in others. The glycoprotein spikes on its outer envelope give the impression that the virus is reaching out to glom on to anything in its path, which is exactly what it is programmed to do.
HIV virus can replicate only in CD4 cells of our immune system (in other words they can only replicate in cells having CD4 receptors on them, whereas in layman’s language receptor can be said to be kind of lock which HIV is capable of opening in order to enter the particular cell).
In previous research, Garcia and his team have effectively prevented intravenous, rectal, vaginal and oral transmission of HIV in the mice with pre-exposure prophylaxis (PrEP). Related Story: "SIV's natural hosts can reveal how humans might better manage HIV infection"Max Cooper focuses on the antibody-producing cells of the immune system and is currently applying his research on lamprey immune proteins to studies of HIV.
For a retrovirus like HIV to survive, it must get inside host cells and use the machinery of those cells to reproduce. Online services help people to get answers to their questions and still maintaining privacy. Related Story: "Present at the creation of modern immunology"Susan Allen's research on heterosexual transmission of HIV in Africa has established interventions that reduce its transmission and provide clues for developing a vaccine.
You can get a flu-like illness 2-6 weeks after catching HIV which can be accompanied with a fever, sweats, rash, sore throats… But of course all of those symptoms are very non-specific. Related Story: "What Rwanda has taught us about HIV testing"Rafi Ahmed has made significant discoveries about how immune memory cells are created and how long they survive, knowledge that is crucial to developing an HIV vaccine. Related Story: "Emory Vaccine Center receives $7 million from NIH"Rama Amara guides a research program aimed at developing both a protective vaccine for uninfected people and a therapeutic one for those already infected by HIV. Related Story: "Scientists spotlight HIV virus transmitter"PlayEmory Vaccine Center scientists are working together to understand how to induce neutralizing antibody responses in virus-fighting cells.



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