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Author: admin, 30.05.2014. Category: Severe Tinnitus Symptoms

Scientists believe they are getting closer to finding a cure for difficult-to-treat brain tumuors in children. According to experts, research has shown that more curable tumours develop 'leaky' blood vessels in the early stages of the condition. Join tens of thousands of doctors, health professionals and patients who receive our newsletters. At Medical News Today, hardly a day goes by without coming across a study about Alzheimer's disease.
In the US, around 5 million people aged 65 and over are living with Alzheimer's, the majority of whom are women. Onset is most common in individuals aged 65 and over, although people in their 40s and 50s can develop what is classed as early-onset Alzheimer's. Alzheimer's is a progressive disease, meaning memory loss is mild in the beginning, but it worsens over time to the extent that individuals are unable to have conversations or respond to their surroundings. There are treatments that have been approved by the US Food and Drug Administration (FDA) for Alzheimer's. Current Alzheimer's prevalence in the US makes it the 6th leading cause of death, killing more than half a million seniors every year. As with all diseases, knowing exactly what causes Alzheimer's is key to identifying ways to prevent and treat the condition. Past research has indicated that Alzheimer's occurs when two abnormal brain structures - plaques and tangles - damage and kill nerve cells, causing the memory, thinking and behavioral problems associated with the disease.
Past research has indicated that Alzheimer's occurs when two abnormal brain structures - plaques and tangles - damage and kill nerve cells. Plaques are fragments of a protein called beta-amyloid, which build up in areas between nerve cells. Although the jury is still out on the exact roles plaques and tangles play in the development of Alzheimer's, studies have suggested that build up of these proteins begins long before symptoms develop. Other research has suggested that targeting these abnormal structures could treat Alzheimer's. Some studies claim that lifestyle factors may be a driver of plaques and tangles typical of Alzheimer's. More recently, researchers have found evidence that genes play an important role in the development of Alzheimer's. Studies have shown that the majority of early onset Alzheimer's cases are inherited - a form of the condition known as familial Alzheimer's disease (FAD). According to the National Institute on Aging (NIA), such findings so far have helped researchers better understand how brain abnormalities form in early-onset Alzheimer's.
When it comes to late-onset Alzheimer's, studies have associated a gene called apolipoprotein E (APOE) to its development.
Last year, a study published in Nature Genetics revealed the discovery of 11 genes that may increase a person's risk of Alzheimer's, while another study found a variation in the ABCA7 gene that may increase the risk of Alzheimer's in African-Americans.

It seems there is more focus on Alzheimer's research than ever before, and a great deal of progress has been made as a result. The last 20 years alone have seen the discovery of the role beta-amyloid and tau proteins play in Alzheimer's, FDA approval of the first Alzheimer's drug for memory and thinking symptoms, the first Alzheimer's mouse model and the first potential blood test for Alzheimer's. As a result of Alzheimer's research, there are an array of drugs in development that scientists believe have great potential to effectively treat the disease.
Although there has been good progress in the Alzheimer's research field, organizations believe there is a lot more that needs to be done, particularly when it comes to funding.
Snyder told Medical News Today that this lack of funding is something that needs to be overcome in order to develop new treatment and prevention strategies for Alzheimer's. In addition, Snyder said a lack of volunteers for Alzheimer's research is also a barrier to progression. In an attempt to tackle this problem, Snyder said the Alzheimer's Association have launched a clinical trials matching service called TrialMatch. To volunteer for a clinical trial, please visit the Alzheimer's Association research center.
Alzheimer's and health care organizations admit there there are a lot of challenges to tackle before a cure for the disease is found. But there is certainly a great deal of confidence that one day, Alzheimer's will be eliminated from existence.
To find out more about Alzheimer's, please visit the Alzheimer's Association website if in the US, or the Alzheimer's Society website if in the UK. Alzheimer's Association, 2014 Facts and Figures, What is Alzheimer's?, Major Milestones in Alzheimer’s and Brain Research, accessed 20 August 2014.
World Health Organization, Dementia cases set to triple by 2050 but still largely ignored, accessed 20 August 2014. National Institute of Aging, Alzheimer's fact sheets, Alzheimer's genetics fact sheet, accessed 20 August 2014.
Please use one of the following formats to cite this article in your essay, paper or report:MLAWhiteman, Honor. For any corrections of factual information, or to contact our editorial team, please see our contact page. Please note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. Taking a close look at dementia, a broad term for a progressive deterioration in cognitive function.
They believe that this information could prove beneficial in helping them to advance the treatment of other tumours. Jonathan Mermin said the new numbers are a cause for hope, while another HIV expert said they are hardly good news. There is no doubt that scientists across the world are working hard to find ways to prevent, treat and cure this debilitating condition, which affects almost 36 million people globally.

Alois Alzheimer, Alzheimer's disease is the most common form of dementia, accounting for around 60-80% of cases.
For example, cholinesterase inhibitors and memantine can help treat memory and thinking problems. To put this in perspective, Alzheimer's disease currently kills more people each year than prostate cancer and breast cancer combined. In the last month alone, we have reported how scientists restored memory and learning deficits in Alzheimer's mouse models, how vitamin D deficiency could increase the risk of developing dementia, and how DNA methylation in the brain is linked to Alzheimer's.
Earlier this year, Medical News Today reported on a study by researchers from the University of California-Irvine, suggesting that increasing brain cell connections could reduce plaque accumulation. Research from Temple University in Philadelphia, PA, for example, suggests that chronic sleep deprivation may cause these abnormal brain structures. Researchers have found that these gene mutations can lead to the development of abnormal proteins in the brain. They have also led to the development of imaging tests that can show how abnormal proteins build up in the living brain.
One form of the gene in particular - APOE E4 - has been linked to an increased risk of the disease. But every gene that is linked to Alzheimer's can increase researchers' understanding of how the disease develops, therefore raising the likelihood of finding ways to prevent and treat the condition. Laurie Ryan told us there are "reasons to be hopeful" when it comes to finding effective treatments for Alzheimer's. Laurie Ryan, of the Division of Neuroscience at the NIA, said that there are "reasons to be hopeful" when it comes to finding effective treatments for Alzheimer's. In the US, for example, Alzheimer's research received $504 million in funding from the National Institutes of Health last year, while cancer received more than $5 billion. But how close are scientists to developing effective prevention and treatment strategies for the disease? Figures are similar worldwide; by 2050, more than 115 million people are expected to have the disease. Another study suggests regular caffeine consumption could halt development of tangles, while research from the Icahn School of Medicine at Mount Sinai in New York, NY, claims eating grilled meat can increase the development of plaques. For example, mutations on chromosome 21 can cause formation of abnormal amyloid precursor protein (APP). Most recently, a study reported by Medical News Today claims that women with a variant of this gene are more likely to develop Alzheimer's than men.

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