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We use cookies to enhance your visit to our site and to bring you advertisements that might interest you. Seal coating is an important tool in extending the life of pavement and should not be overlooked. What leads to the deterioration of asphalt?A  The number one offender is water!A  Water causes clay expansion, washes away dirt and can erode rock supporting asphalt.A  This is why it is imperative that a site is properly graded and drained at installation. Other factors that can deteriorate an asphalt surface include oxidative properties of ultraviolet light which can denature the surface of asphalt.
We recommend year round scheduled maintenance with inspections in spring and fall and crack sealing and repair as indicated. Although the terms cement and concrete often are used interchangeably, cement is actually an ingredient of concrete.
So, there is no such thing as a cement sidewalk, or a cement mixer; the proper terms are concrete sidewalk and concrete mixer. Materials that contain appropriate amounts of calcium compounds, silica, alumina and iron oxide are crushed and screened and placed in a rotating cement kiln. The kiln resembles a large horizontal pipe with a diameter of 10 to 15 feet (3 to 4.1 meters) and a length of 300 feet (90 meters) or more.
Curing is one of the most important steps in concrete construction, because proper curing greatly increases concrete strength and durability. Good concrete can be obtained by using a wide variety of mix proportions if proper mix design procedures are used. Concrete is tested to ensure that the material that was specified and bought is the same material delivered to the job site.
The real indicator is the yield, or the actual volume produced based on the actual batch quantities of cement, water and aggregates.
Portland cement is a hydraulic cement which means that it sets and hardens due to a chemical reaction with water.
It is concrete that is strong enough to carry a compressive stress of 3,000 psi (20.7 MPa) at 28 days. Stains can be removed from concrete with dry or mechanical methods, or by wet methods using chemical or water. Common dry methods include sandblasting, flame cleaning and shotblasting, grinding, scabbing, planing and scouring. Wet methods involve the application of water or specific chemicals according to the nature of the stain. To remove blood stains, for example, wet the stains with water and cover them with a layer of sodium peroxide powder; let stand for a few minutes, rinse with water and scrub vigorously. Color may be added to concrete by adding pigments-before or after concrete is place-and using white cement rather than conventional gray cement, by using chemical stains, or by exposing colorful aggregates at the surface. Each country has its own standard for portland cement, so there is no universal international standard. Alkali-silica reactivity is an expansive reaction between reactive forms of silica in aggregates and potassium and sodium alkalis, mostly from cement, but also from aggregates, pozzolans, admixtures and mixing water. White portland cement is made from raw materials containing little or no iron or manganese, the substances that give conventional cement its gray color. If you have a question that was not answered in this section, please contact us and we will be happy to answer it! To understand ourselves it is important to understand our ancestors, and a part of them, and their heritage, lives on in us today. To the world the American Indians seemed like a forgotten people when the English colonists first arrived and began to occupy their lands.
I want to give special thanks to my cousin, Mary Hilliard, for her assistance and encouragement in researching and preparing this book. Wherever possible I have tried to find at least two sources for the genealogical data, but this has not always been possible. I have also found Franklin Elewatum Bearce's history, Who Our Forefathers Really Were, A True Narrative of Our White and Indian Ancestors, to be very helpful. It is certainly possible that such a record may contain errors, but it is also very fortunate that we have access to this record as it presents firsthand knowledge of some of the individuals discussed in this book. 8 Newcomba€? Cpt. Sometime before the colonial period, the Iroquoian tribes began moving from the southern plains eastward across the Mississippi River and then northeasterly between the Appalachians and the Ohio River Valley, into the Great Lakes region, then through New York and down the St. Though they were neighbors and had similar skin color, these two groups of Indians were as dissimilar as the French and the Germans in Europe. Federations, as well as the individual tribes, were fluid organizations to the extent that the sachem was supported as long as he had the strength to maintain his position.
Belonging to a federation meant that an annual tribute had to be sent to support the great sachem and his household, warriors had to be sent if he called for a given number to go to war, and strictest obedience and fidelity was demanded. Some of these federations had as many as thirty member tribes supporting their Great Sachem, although many of these tribes would be counted by more than one sachem, as any tribe that was forced to pay tribute was considered as part of that Great Sachem's federation.
Any member of the society who dishonored himself, in anyway, was no longer worthy of the respect of his people. When viewing the typical Indians of America, one would describe them as having a dark brown skin. They wore relatively little clothing, especially in summer, although the women were usually somewhat more modest than the men. The English resented the fact that the Indians wouldn't convert to Christianity as soon as the missionaries came among them. The various tribes of New England spoke basically the same language and could understand each other well. There are many words used commonly in our language today that were learned from these New England Indians: Squaw, wigwam, wampum, pow-wow, moccasin, papoose, etc. Today there is little doubt that prior to Columbus's voyage, the Norsemen sailed to the coast of North America early in the eleventh century. We do not have a record of all of the European contact and influence on the Indians in the early years of exploration because the greatest exposure came from the early European fishermen and trappers who kept no records of their adventures, as opposed to the explorers. In 1524, Giovanni da Verrazano wrote the first known description of a continuous voyage up the eastern coast of North America. As the fur trade became increasingly more important to Europeans, they relied heavily on the Indians to do the trapping for them. Another problem with which the Indians had to contend was the White man's diseases for which they had no tolerance nor immunity.
In the spring of 1606, Gorges sent Assacumet and Manida, as guides on a ship with Captain Henry Chalons, to New England to search for a site for a settlement. In 1614, Captain John Smith, who had already been involved in the colony at James Town, Virginia, was again commissioned to take two ships to New England in search of gold, whales or anything else of value. Dermer wanted to trade with the local Indians of the Wampanoag Federation and asked Squanto if he would guide them and be their interpreter. Derner was given safe passage through Wampanoag land by Massasoit and soon returned to his ship.
When the Pilgrims left England in the Mayflower, their stated intent was to establish a settlement on the mouth of the Hudson River, at the site of present day New York City. The Pilgrims returned to the Mayflower and, after many days of exploration, found a more suitable location. On March 16, 1621 the Pilgrims were surprised by a tall Indian who walked boldly into the plantation crying out, "Welcome! The Pilgrims gestured for Massasoit to join them in their fort but, he in turn, gestured for them to come to him. When the amenities were ended, the English brought out a treaty they had prepared in advance, which specified that the Wampanoags would be allies to the English in the event of war with any other peoples and that they would not harm one-another; and that when any Indians came to visit the plantation they would leave their weapons behind.
After the ceremonies were ended, Governor Carver escorted Massasoit to the edge of the settlement and waited there for the safe return of Winslow.
Part of Massasoit's willingness to make an alliance with the English must be credited to his weakened condition after suffering from the recent epidemics which left his followers at about half of the strength of his enemies, the Narragansetts. In June of 1621, about three months after the signing of the treaty, a young boy from the Colony was lost in the woods.
When the English could not find the boy, Governor William Bradford, (who replaced John Carver, who died in April) sent to Massasoit for help in locating the boy. That summer Governor Bradford sent Edward Winslow and Stephen Hopkins, with Squanto, to Pokanoket (Massasoit's own tribe, on the peninsula where Bristol, R.I. From this trip of Winslow's, we learn more about the daily life of the Indians in this area. Massasoit urged his guests to stay longer but they insisted they must return to Plymouth before the Sabbath.
Less than a month following this visit, Massasoit sent Hobomock, a high ranking member of the Wampanoag Council, to Plymouth to act as his ambassador and to aid the Pilgrims in whatever way they needed. Hobomock and Squanto were surprised at what they heard, and quietly withdrew from the camp to Squanto's wigwam but were captured there before they could get to Plymouth. Although the Narragansetts and Wampanoags were historical enemies and continually feuding over land, they did not usually put hostages of high rank to death.


Normally, treason was punishable by death and Massasoit would certainly have been justified in executing Corbitant for his part in the plot against him but, for some reason, Massasoit complete forgave him. Their first harvest was not a large one but the Pilgrims were.happy to have anything at all. During the winter, a rivalry developed between Squanto and Hobomock, the two Indians who now lived continually at Plymouth. According to the treaty he had signed with Plymouth, they were to turn over to him any Indians guilty of offense. In June and July, three ships arrived at Plymouth with occupants who expected to be taken in and cared for. In the winter of 1622-23, Governor William Bradford made trips to the various Indian tribes around Cape Cod to buy food to keep the Pilgrims from starvation.
Next, Standish went to Cummaquid (Barnstable, MA.) where Iyanough was Sachem of the Mattachee Tribe.
Thinking that Massasoit was dead, they went instead to Pocasset, where they sought Corbitant who, they were sure, would succeed Massasoit as the next Great Sachem. Winslow describes their arrival, where the Indians had gathered so closely that it took some effort to get through the crowd to the Great Sachem. Since the Pow-wow's medicine had not produced any results, Winslow asked permission to try to help the ailing Sachem.
Their second Thanksgiving was combined with the wedding celebration of Governor Bradford and Alice Southworth. Because of Massasoit's honored position, more was recorded of him than of other Indians of his time.
Massasoit most likely became Sachem of the Pokanokets, and Great Sachem of the Wampanoags, between 1605-1615. The second son of Massasoit was Pometacomet, (alias Pometacom, Metacom, Metacomet, Metacomo or Philip.) Philip was born in 1640, at least 16 years younger than Alexander.
The third son, Sunconewhew, was sent by his Father to learn the white man's ways and to attend school at Harvard. When his two oldest sons were old enough to marry, Massasoit made the arrangements for them to marry the two daughters of the highly regarded Corbitant, Sachem of the Pocasset tribe.
The tribes of Cape Cod, Martha's Vineyard, Nantucket, as well as some of the Nipmuck tribes of central Massachusetts, looked to him for Military defense and leadership. Following the plagues of 1617, which reduced his nation so drastically and left his greatest enemy, the Narragansetts of Rhode Island, so unaffected, Massasoit was in a weakened position. In 1632, following a battle with the Narragansetts in which he regained the Island of Aquidneck, Massasoit changed his name to Ousamequin (Yellow feather) sometimes spelled Wassamegon, Oosamequen, Ussamequen.
In 1637, the English waged an unprovoked war of extermination against the Pequot Federation of Connecticut, which shocked both the Wampanoags and the Narragansetts so much that both Nations wanted to avoid hostilities with the feared English.
After hearing of the death of his good friend, Edward Winslow in 1655, Massasoit realized that his generation was passing away. As Massasoit's health began to decline, he turned more and more of the responsibilities over to Alexander who was a very capable leader and who was already leading the warriors on expedition against some of their enemies. Massasoit was succeeded, as Great Sachem, by his son Alexander, assisted by his brother, Philip. The younger generation saw, in Alexander, a strong, new leader who could see the danger of catering to the English. Both Philip and Weetamoo were very vocal in their condemnation of the English and word of their accusations soon reached Plymouth. Together, Philip and Canonchet reasoned that it would take a great deal of preparation for such a war. Seal coats generally consist of a mixture of emulsified asphalt, water, mineral fillers and various other admixtures.
Future applications of seal coat should be applied at intervals of three to five years, or at times when roadway aesthetics are not up to par with the balance of the community. Ingredients used in this process are typically materials such as limestone, marl, shale, iron ore, clay, and fly ash.
These air pockets relieve internal pressure on the concrete by providing tiny chambers for water to expand into when it freezes.
There are a dozen different test methods for freshly mixed concrete and at least another dozen tests for hardened concrete, not including test methods unique to organizations like the Army Corps of Engineers, the Federal Highway Administration, and state departments of transportation. If the concrete can't flow because the consistency or slump is too low, there are potential problems with proper consolidation. Three field tests are widely specified: the pressure meter and volumetric method are ASTM standards and the Chace Indicator is an AASHTO procedure.
According to Building Code Requirements for Reinforced Concrete (ACI 318), as long as no single test is more than 500 psi below the design strength and the average of three consecutive tests equals or exceed the design strength then the concrete is acceptable. The unit weight test can be used to determine the yield of a sample of the ready mixed concrete as delivered. Too much water in the mix will produce a weaker, less durable concrete that will contribute to early flaking and spalling of the surface. If this excess water is worked into the concrete because the finishing operations are begun too soon, the concrete on the surface will have too high a water content and will be weaker and less durable.
The factor that most predominantly influences concrete strength is the ratio of water to cement in the cement paste that binds the aggregates together. Steel-wire brushes should be used with care because they can leave metal particles on the surface that later may rust and stain the concrete.
The chemical treatment either dissolves the staining substance so it can be blotted up from the surface of the concrete or bleaches the staining substance so it will not show. Follow with the application of a 5 percent solution of vinegar to neutralize any remaining sodium peroxide. However, there are some aggressive materials, such as most acids, that can have a deteriorating effect on concrete.
The United States uses the specification prepared by the American Society for Testing and Materials-ASTM C-150 Standard Specification for Portland Cement. External sources of alkali from soil, deicers and industrial processes can also contribute to reactivity. They have the same properties as types I, II, and III, except that they have small quantities of air-entrained materials combined with them.
At first I was very skeptical of this record as it was a family tradition passed down for many generations. She was very fond of her Grandmother, Freelove, knew all about her and stated on several occasions that Freelove's Mother was Sarah Mauwee, daughter of Joseph Mauwee, Sachem of Choosetown, and not Tabitha Rubbards (Roberts). Massasoit was the Sachem of this tribe, as well as being the Great Sachem over the entire Wampanoag Federation, which consisted of over 30 tribes in central and southeastern Massachusetts, Cape Cod, Martha's Vineyard and Nantucket. Welcome, Englishmen!" It was a cold and windy day, yet this Indian, who introduced himself as Samoset, Sachem of a tribe in Monhegan Island, Maine, wore only moccasins and a fringed loin skin.
How close is the collaborative research ecosystem to achieving these goals, and what do we have to do to get there?
MBAVice President, Oncology Global Marketing Strategy, Astellas PharmaceuticalsCollaboration amongst various entities across the research and development continuum are becoming more varied within the field of oncology. How close is the collaborative research ecosystem to achieving these goals, and what do we have to do to get there?Watch John Schafer's Video ResponseCollaboration amongst various entities across the research and development continuum are becoming more varied within the field of oncology. Much of the success of treatment is believed to be down to the swiftness and intensity of the antiretroviral dosage that was so potent. The process seals the top of the asphalt, preventing water from penetrating the surface of the pavement and protecting the top layer of asphalt from oxidation and wear caused by exposure to the sun. The thickness of the wearing surface will depend on the number of coats applied and the amount of water added by the contractor. The aggregates are sand and gravel or crushed stone; the paste is water and portland cement. The raw mix is placed in the high end and as the kiln rotates the materials move slowly toward the lower end. However, hydration occurs only if water is available and if the concrete's temperature stays within a suitable range. Air-entrained concrete is produced through the use of air-entraining portland cement, or by the introduction of air-entraining agents, under careful engineering supervision as the concrete is mixed on the job.
If the concrete won't stop flowing because the slump is too high, there are potential problems with mortar loss through the formwork, excessive formwork pressures, finishing delays and segregation. Conventional concrete has strengths of 7,000 psi or less; concrete with strengths between 7,000 and 14,500 psi is considered high-strength concrete.
Geometric patterns can be scored, stamped, rolled, or inlaid into the concrete to resemble stone, brick or tile paving.
The first line of defense against chemical attack is to use quality concrete with maximum chemical resistance, followed by the application of protective treatments to keep corrosive substances from contacting the concrete. There are a few other countries that also have adopted this as their standard, however, there are countless other specifications. The reaction forms an alkali-silica gel that swells as it draws water from the surrounding cement paste, thereby inducing pressure, expansion and cracking of the aggregate and surrounding paste. She obtained her copy of Zerviah Newcomb's Chronical from Zerviah's original diary, in the hands of Josiah 3rd himself.


Usually a child is given a course of one drug.While the findings are encouraging, scientists warned they are not the definitive cure for HIV.
Remember, seal coat is water soluble, so it is important to deal with reputable contractors in the asphalt-maintenance business.
Flame jets are at the lower end and all the materials in the kiln are heated to high temperatures that range between 2700 and 3000 Fahrenheit (1480 and 1650 Celsius).
During the curing period-from five to seven days after placement for conventional concrete-the concrete surface needs to be kept moist to permit the hydration process. The amount of entrained air is usually between 4 percent and 7 percent of the volume of the concrete, but may be varied as required by special conditions. The reason that contractors put joints in concrete pavements and floors is to allow the concrete to crack in a neat, straight line at the joint when the volume of the concrete changes due to shrinkage. The total weight information may be shown on the delivery ticket or it can be provided by the producer. Every desirable physical property that you can measure will be adversely effected by adding more water.
Other interesting patterns are obtained by using divider strips (commonly redwood) to form panels of various sizes and shapesA  rectangular, square, circular or diamond. Principles and practices that improve the chemical resistance of concrete include using a low water-cement ratio, selecting a suitable cement type (such as sulfate-resistant cement to prevent sulfate attack), using suitable aggregates, water and air entrainment. This often results in map-pattern cracks, sometimes referred to as alligator pattern cracking. One such example is The Biomarkers Consortium, a research partnership managed by the Foundation for the National Institutes of Health. It is thought to have been the speed and intensity of the action that knocked out HIV in the baby's blood before it could form hideouts in the body. Good looks are an added benefit, but seal coating is not just for aesthetics--it will actually extend pavement life.
Portland cement is not a brand name, but the generic term for the type of cement used in virtually all concrete, just as stainless is a type of steel and sterling a type of silver. This high heat drives off, or calcines, the chemically combined water and carbon dioxide from the raw materials and forms new compounds (tricalcium silicate, dicalcium silicate, tricalcium aluminate and tetracalcium aluminoferrite). In general, the temperature of new concrete should not be allowed to fall below 50 Fahrenheit (10 Celsius) during the curing period. This would be impractical, so a time period of 28 days was selected by specification writing authorities as the age that all concrete should be tested. A large number of chemical formulations are available as sealers and coatings to protect concrete from a variety of environments; detailed recommendations should be requested from manufacturers, formulators or material suppliers. ASR can be avoided through 1) proper aggregate selection, 2) use of blended cements, 3) use of proper pozzolanic materials and 4) contaminant-free mixing water.
Bearce's Great-aunt, Mary Caroline, lived with Josiah III and Freelove Canfield Bearce for several years, listened to their ancestral stories, and made her own personal copy of Zerviah's diary supplement. Lawrence to what is now known as Lake Champlain where his party killed several Mohawks in a show of European strength and musketry. This public-private biomedical research alliance is working on advancing drug development by discovering and qualifying biomarkers.Additionally, patient advocacy groups such as Multiple Myeloma Research Foundation or the Leukemia and Lymphoma Society are partnering with pharmaceutical companies to fund and conduct clinical trials. For each ton of material that goes into the feed end of the kiln, two thirds of a ton the comes out the discharge end, called clinker.
But other producers may not even realize that a mix designed for one cubic yard might only produce 26.5 cubic feet or 98 percent of what they designed. We are making huge strides in preventing, slowing and in some cases beating many forms of cancer, but there are still considerable roadblocks to reaching our ultimate goal of a world free from cancer. And, many of the most recent advances in cancer research have come from collaborations between companies and academic research institutions.Open source clinical data is one of the most exciting and promising results of collaboration. Dr Deborah Persaud of Johns Hopkins Children's Center, who led the investigation, said that the child was in effect "functionally cured", meaning in long-term remission even if all traces of the virus haven't been completely eradicated.The treatment would not work in older children or adults as the virus will have already infected cells. Through a process called hydration, the cement and water harden and bind the aggregates into a rocklike mass.
In this effort, companies are pooling their collective clinical trial data and making it available to others.
The number of babies born with HIV in developed countries has fallen dramatically with the advent of better drugs and prevention.
This hardening process continues for years meaning that concrete gets stronger as it gets older. Typically, women with HIV are given antiretroviral drugs during pregnancy to minimise the virus in their blood. A small amount of gypsum is added during the grinding process to control the cement's set or rate of hardening. Through this alliance approximately 400,000 selected compounds are available to Astellas and Daiichi Sankyo that can be accessed quickly and used to develop innovative new drugs.It is collaborative efforts like these that may hopefully lead to new treatments for cancers of all types. Working in a vacuum cannot produce the innovation needed to tackle the problem and luckily, more and more partnerships are forming amongst various entities. The strategy can stop around 98% of HIV transmission from mother to child.About 300,000 children were born with HIV in 2011. Along with innovators and researchers across the globe, we couldn’t be more excited about what the future holds for patients who rely on us for treatments.Josh Schafer, MSc. In the US such births are very rare as HIV testing and treatment long have been part of prenatal care.
He further told them that Massasoit, the Great Sachem of the Wampanoags, was at Nemasket (a distance of about 15 miles) with many of his Counselors.
MBA Vice President, Oncology Global Marketing Strategy, Astellas PharmaceuticalsRead biography×Josh Schafer, MSc. We can promise to prevent the vast majority of transmissions if the moms are tested during every pregnancy," said Dr Hannah Gay, of the University of Mississippi.The only other person considered cured of the AIDS virus underwent a bone marrow transplant from a donor naturally resistant to HIV.
Timothy Ray Brown of San Francisco has not needed HIV medications in the five years since that transplant. The Mississippi case shows "there may be different cures for different populations of HIV-infected people," said Dr Rowena Johnston of amFAR, the Foundation for AIDS Research.
It also suggests that scientists should look back at other children who've been treated since shortly after birth, including some reports of possible cures in the late 1990s that were dismissed, said Dr. How close is the collaborative research ecosystem to achieving these goals, and what do we have to do to get there?The crosstalk between all parties in the process of discovery, development and commercialization of medicines has undergone significant evolution in the recent past. Advances in scientific understanding of cancer biology, coupled with societal demands for higher therapeutic value have led to collaborations among industry to develop therapeutic combinations that work in synergy and circumvent resistance. Industry has increased interactions in recent past with regulators and academia, particularly in the context of multi-party discussions to inform regulatory policy.
This has been aggravated by limitations in basic research funding in many geographies coming from governmental sources.The medicines of the future will likely come from the emergence of basic scientific discovery at industry and academic laboratories working in close partnership. In that capacity he was responsible for developing and executing the asset’s development strategy globally. He served in positions of increasing responsibility as Vice President, Oncology Solid Tumors and Senior Vice President, Oncology Development, to his current role of head of Oncology R&D.
An area of his interest is biological characterization of tumors for patient selection, which he successfully applied to targeted drug development with EGFR inhibitors in colorectal cancer. How close is the collaborative research ecosystem to achieving these goals, and what do we have to do to get there?Like both sides of a coin, there are two sides in the battle against cancer. We are making huge strides in preventing, slowing and in some cases beating many forms of cancer, but there are still considerable roadblocks to reaching our ultimate goal of a world free from cancer.Let’s start with the good news. For most of the 20th Century a diagnosis of cancer was seen as a death sentence – but no longer.
Our early understanding of the related biological processes was relatively minimal as researchers initially believed cancer was a monolithic disease.
Today, however, researchers in academia, the government and biopharmaceutical companies have come to better grasp the molecular and genetic underpinnings of many cancers, which is providing countless new roadmaps and opportunities to identify new treatment approaches.Since the 1970s, the five-year survival rate for cancer has risen from 58 percent to 83 percent. According to the Journal of Health Economics, medicines have been at the forefront, even more so than early detection, in the battle against cancer. Each new cancer medicine, whether it extends a life for six months or six years, has helped researchers open a new set of doors into drug discovery.Globally, there are over 3,000 cancer medicines in development around the world, with 80 percent having the potential to be first-in-class treatments.
Although the vast majority of these projects will not result in approved medicines for patients, they represent an exciting new scientific chapter in progressing our knowledge towards a cure.Every innovation in cancer treatment – many involving precision or personalized medicines linked to a diagnostic that helps determine whether a patient will be more likely to respond to a medicine – offers tremendous hope for new treatment options. For example, we are working to improve the clinical trials process through efforts such as I’m In, a campaign designed to increase awareness and participation in clinical trials among traditionally underrepresented populations, and Project Data Sphere, an independent initiative of the CEO Roundtable on Cancer's Life Sciences Consortium.
Project Data Sphere, which launched just a couple of months ago, creates a platform for researchers from industry and academia to responsibly share and analyze patient-level phase III cancer data. The goal is to facilitate improved trial design, reduce duplication and develop broad data standards.These are exciting times for cancer innovation.
He carries overall responsibility for establishing PhRMA as a “go to” source for input on policies and legislation related to innovative approaches to biopharmaceutical discovery and development.



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