Clear tinnitus capsules reviews 2014,tinnitus behandeling belgie folder,tenis nike azul mercadolivre - Reviews

Author: admin, 11.02.2015. Category: Is There A Cure For Tinnitus

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We hypothesize that relief in the ear with the tinnitus complaint may result from oral intake of Clear Tinnitus for patients with severe disabling tinnitus in whom the factor of aeration of the middle ear and that of eustachian tube dysfunction is identified and treated. Interference in aeration of the middle ears accompanying allergy and inflammation of the upper respiratory tract has been identified via a medical-audiological tinnitus patient protocol (MATPP) to be a factor that can influence the clinical course of subjective idiopathic tinnitus of the severe type [6-8]. Historically, the influence of aeration of the middle ear "effecting permeability of the eustachian tube" was reported by Politzer in 1863 [9].
Since 1979, the tinnitus clinic of the Health Science Center at Brooklyn, State University of New York, and the Martha Entenmann Tinnitus Research Center, Inc., have reported on more than 10,000 patients who had subjective idiopathic tinnitus (seen in neurotological consultation) and completed the MATPP.
The prospect of a trial of Clear Tinnitus to attempt tinnitus relief in a selected cohort of patients who have subjective idiopathic tinnitus and exhibit objective evidence of interference in eustachian tube function provided a clinical opportunity to use our established experience to test the efficacy claimed for this preparation.
We selected 15 individuals with reported subjective, severe, disabling idiopathic tinnitus lasting at least 1 year. The parameters of the patients' tinnitus included tinnitus intensity, location, masking characteristic, and duration. All 15 subjects reported the tinnitus to be of the severe disabling type lasting for at least 1 year. The homeopathic preparation for tinnitus relief- Clear Tinnitus-was taken on a daily basis. The patients in this study completed multiple measures for evaluating the subjective idiopathic tinnitus and the hypothesized tinnitus relief.
We identified for each patient multiple risk dimensions known to influence the clinical course of subjective, idiopathic, severe, disabling tinnitus, with a focus on fluctuation of aeration of the middle ear and eustachian tube dysfunction. We used multiple objective measures to evaluate the risk dimensions for each tinnitus patient.
The measures included audiological testing via puretone audiometry and speech audiometry performed using a Beltone 2000 audiometer.
Extensive scientific research has been carried out on the preparation's chemical composition, and pharmacological and clinical research has focused on its individual herbs. We performed all statistical analyses using the Statistical Package for the Social Sciences (SPSS Release 14) [19]. Regression analysis failed to detect any trends in the change in response to audiometric tests across the hearing spectrum; thus, we could not derive coefficients of change for testing. Ultra-high-frequency audiometry (UHFA) did not show any clinically significant change in threshold at 10,000-20,000 Hz before and after testing with airconduction high-frequency or electrical high-frequency audiometry. In the 11 patients completing the study, all masking curves were either type I or type IV according to Feldmann's classification system. Minimum masking level (MML) changes for the right ear before and after the study are reported for 10 individuals, as 1 had no tinnitus at the end of the study. We established LDLs at 250-8,000 Hz for the right and left ears before and after the study (Table 5). For the tympanogram type, using -100 mm H2O as abnormal, three of the seven responders went from type C tympanogram to type A. Both responders and nonresponders (N = 11) correlated to recorded MEPs before and after the study (see Table 1).
We found improvement in aeration of the middle ear, as established by tympanometry and supported by physical examination of the tympanic membranes, in eight patients. Five of the seven patients reporting subjective tinnitus abatement recorded MEP improvement at the start and conclusion of the study.
A nonsignificant difference occurred over time when testing for a quadratic change over the course of the study, with a lowering of the total significant abnormal recordings.
We analyzed the results of the outcome questionnaires as an average for all patients who completed the study (N = 11) and separately for the responders (n = 7) and nonresponders (n = 4; Table 7).
The measurement of depression test (Zung) indicated a mean change of -2.27 before and after the study, which also was not considered statistically significant. In summary, a statistically significant improvement in one or more of the outcomes (TII, TAI, TRQ) was identified in six of seven patients reporting tinnitus relief. This study differentiated between the efficacy of the Clear Tinnitus preparation for maintenance and improvement of MEP and the correlation of the MEP improvement with reported tinnitus relief. Seven of the 11 patients reported relief from severe, disabling-type tinnitus after oral intake of Clear Tinnitus.
The clinical course of the tinnitus patients selected for this study was identified, by their clinical history and physical examination, to have been influenced by fluctuation of MEP. The patients' clinical history was positive for the association of tinnitus intensity fluctuation with the subjective report of ear blockage-specifically, increased tinnitus intensity with increased ear blockage and vice versa. The regression analysis failed to detect any trends in a change in response with audiometric tests across the hearing spectrum; thus, we could not derive coefficients of change from testing. The range of normal and abnormal MEP varies in reports from different investigators (from -25 mm H2O to -100 mm H2O) [20-26]. The QEEG testing was recommended in this study to improve the accuracy of the tinnitus diagnosis. Clinically, when interpreted in terms of the tinnitus dyssynchrony-synchrony theory, the QEEG data in this study are considered to provide an understanding of the clinical course of the tinnitus in the patients in this study and of the efficacy of the Clear Tinnitus therapy attempting tinnitus relief [2]. The outcome results reflect the dilemma of all professionals involved in attempting to evaluate modalities of therapy attempting tinnitus relief: specifically, how a subjective response becomes one of affect and how a subjective response might be objectified [1,13].
The 11 tinnitus patients who completed the study demonstrated with tympanometry a statistical and clinical significance in MEP improvement (n = 8) or maintenance of MEP (n = 3) or both. The subjective report of tinnitus relief in those seven patients was supported by objective measures of analysis in five patients; the remaining two responders recorded normal MEP before and after the study. We gratefully acknowledge the support of Clear Products and the Martha Entenmann Tinnitus Research Center, Inc., for this educational and research effort.
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Our goal was to establish the efficacy, in a 12-week period, of Clear Tinnitus for tinnitus relief in patients with tinnitus of the severe, disabling type. We employed a descriptive data analysis method across dimensions of risk to evaluate a base of multidimensional evidence to support our hypothesis. We clinically identified all patients in this study as having subjective idiopathic tinnitus of the severe type lasting at least 1 year. A focus on risk factors for each tinnitus patient provides an increased level of flexibility for interpretation of the clinical significance of the results of a treatment method and its future application for tinnitus relief. Its application for hearing improvement and tinnitus relief has been reported in his classic textbook: "When there are accumulations of secretion in the middle ear, or anomalies of tension in the sound conducting apparatus which bring about an increased pressure in the labyrinth, it has been found inflations of air into the middle ear and rarefaction of air in the external meatus are often the most effectual means by which these subjective noises are overcome" [10].
Significant tinnitus relief was obtained in approximately 10-15% of tinnitus patients in whom identification of and satisfactory treatment for the factor of aeration of the middle ear and of eustachian tube dysfunction was completed [6-8,11,12].
Using multiple measures of analysis of risk factors, this study presents the results and conclusions of attempted tinnitus relief with Clear Tinnitus. The 15 patients variously reported a bilateral tinnitus location (n = 12), a unilateral tinnitus in the right ear (n = 2), bilateral tinnitus in the head and ears (n = 1), a tonal quality to the tinnitus (n = 11), a noise band (n = 1), a combination tone and noise band (n = 3), and high frequency (n = 15; Table 1).
All tinnitus patients completed an MATPP to identify the clinical type of tinnitus and factors influencing the clinical course of their tinnitus [6-8,11,12].
The specific regimen consisted of three capsules taken with food two times daily for 3 months.


The answer to the final question was whether the reported tinnitus relief was considered significant to the patient. We originally planned to use the data obtained to provide a base for a multivariate risk-benefit stratified analysis of the significance of the reported tinnitus relief. Conventional pure-tone audiometry conducted at 250-8,000 Hz (including 3,000 and 6,000 Hz) showed no significant difference in thresholds for either ear at any of the frequencies before and after testing all 11 subjects.
Among our 15 patients, 12 originally reported tinnitus in the ears bilaterally, 2 originally reported unilateral tinnitus in the right ear, and 1 reported tinnitus in the head and ears bilaterally. Five were type I before the study, four were type IV before the study, and two were mixed (type I for one ear and type IV for the other ear). No clear trend in the data for either ear was demonstrated by the mean change in LDL before and after the study. Two patients with a normal starting MEP that remained unchanged reported a positive tinnitus relief outcome, whereas one patient with a normal starting MEP that remained unchanged reported negative tinnitus relief. MEP improvement was recorded in three patients and remained unchanged in one, who had a normal MEP both before and after the study. Results of quantitative electroencephalography (QEEG) recordings of the four EEG frequency bands for the 11 patients completing the study. Results of quantitative electroencephalography (QEEG) recordings of the four EEG frequency bands for the seven responders. Five responders reported positive significance of the tinnitus relief, and two reported it as negative (see Table 6). An improvement in the TII and TAI scores of 2 units or more was reported by four of the seven. All patients who completed the study demonstrated via tympanometry a statistical and clinical significance in MEP improvement (n = 8) or maintenance of MEP (n = 3) or both (see Table 1). As identified with tympanometry, five demonstrated a significant improvement in MEP, and two showed maintenance of a normal MEP (see Table 1). This clinical medical-audiological approach provided a basis for objective interpretation of the reported subjective tinnitus relief with the Clear Tinnitus treatment.
The MATPP electrodiagnostic cochleovestibular test battery identified the tinnitus to be predominantly a cochlear type, bilateral and unilateral, with a middle-ear and central component. Physical examination of the tympanic membranes before and at the conclusion of the study identified mild to moderate scarring of the tympanic membranes consistent with eustachian tube dysfunction. Clinically, this suggests to the limits of examination that the site of Clear Tinnitus action is not cochlear in location. Pitch match did not correlate with outcome measurements, masking curve type, MMLs, or LDLs.
Clinically for this study, tympanometry values for a normal range of MEP were established to be from 0 to -50 mm H2O. It could function as a monitor for establishing the efficacy of the therapeutic modality-Clear Tinnitus-attempting tinnitus relief and aid in understanding the clinical course of the tinnitus as reflected in brain function of memory, consciousness, attention, and affect [3,12].
The low power of the analysis for the nonresponders (n = 4) precluded any conclusion or clinical correlation. To determine patients' baseline responses, we administered questionnaires to record subjective tinnitus at the outset of the study and again at the conclusion. If the reality of the absence of a tinnitus cure at this time is accepted and tinnitus relief is the goal, is relief expected for the tinnitus sensation or for the annoyance and intrusion into one's lifestyle, as manifested in the behavioral response of affected patients to the presence of the tinnitus? Of the 11 patients, 7 with severe, disabling tinnitus and fluctuation of aeration of the middle ears (diagnosed with the MATPP as a factor influencing the clinical course of their tinnitus) reported tinnitus relief with Clear Tinnitus. These results indicate that a slightly larger sample size might have changed the outcome of this analysis.
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The benefits of a risk-stratified multivariate analysis across dimensions of risk, originally planned for this study, could not be achieved owing to an insufficient final sample size [4].
We hypothesize in this study that relief occurs by identifying and treating the factor of aeration of the middle ear. The clinical history of each tinnitus patient reflected periods of tinnitus relief associated with fluctuation of tinnitus intensity and the location and degree of ear blockage. Such an analysis provided information of both the sensory and affect components of the tinnitus complaint [15]. Tinnitus evaluation included pitch and loudness matching, masking curves, and loudness discomfort levels (LDLs). A copy of the manufacturer's cGMP certification and standard operating procedures used in the production of Clear Tinnitus is maintained by Clear Products, Inc. We modeled recordings of audiometric tests across the hearing spectrum using nonlinear regression. The adverse reactions included gastrointestinal complaints (one with gastroesophageal reflux disease and one with bloating and constipation) and ear complaints (one with "ear spasms"). Likewise, speech audiometry did not show any significant difference for speech reception threshold or word discrimination scores before and after testing. The quality was reported as tonal in 11 patients, as noise band in 1, as combined tone and noise band in 3, and as high-frequency in all 15.
After the study, five with type I remained unchanged, and three of the four with type IV remained unchanged.
For the left ear, the eight patients who had tinnitus after the study exhibited a reduction in the masking level of - 11.25 dB at 8,000 Hz (Tables 3 and 4). Of the four who did not report improvement, three went from type C to type A (one on both ears, the other two on one of the two ears; see Table 1). Two patients whose MEP was abnormal to start but changed to normal reported positive tinnitus relief, whereas three patients whose MEP was abnormal to start but changed to normal reported negative tinnitus relief. The number of significant abnormal power recordings was identified with a normative database and analyzed by the Lexicor Corporation.
When tested by a paired Student's t-test for change over the course of the study, only the TII, the TAI, and the TRQ demonstrated a significant decrease in the patients' responses.
One patient reported tinnitus relief, improvement in MEP, and no improvement in outcome measures. A multidimensional method of analysis across dimensions of risk is recommended for all clinical studies attempting to evaluate the efficacy of therapeutic modalities attempting tinnitus relief.
The clinical type of this tinnitus correlates with the patients' reports of tinnitus relief in five of seven. The reported improvement in MEP with tympanometry was associated with reported subjective abatement in ear blockage in the tinnitus ear and with evidence of increased aeration of the middle ear on physical examination of the tympanic membrane.
Otoacoustic emission tests in the future may provide a basis for audiological coefficients of change. In the 11 patients completing the study, all masking curves were either type I or type IV, according to Feldmann's classification system. The Clear Tinnitus preparation did not significantly influence the tinnitus evaluation measures consisting of pitch match, masking curves, MMLs, or LDLs. The QEEG results are considered to be electrophysiological brain function responses hypothesized to reflect a synchrony of responses at the cortex in the central nervous system (see Fig.
The delta band was significantly higher than the alpha and beta bands both for the overall cohort of 11 patients and for the 7 reporting tinnitus relief (see Table 5; see Figs. In only one patient in this study, demonstration of the theta and its increase may reflect the persistence of the tinnitus and the ongoing development of a paradoxical memory for the dyssynchronous auditory signal-tinnitus [2,3,27-29].
Of the six outcome measures, only the TII, TIA, and TRQ reported the data to be statistically significant (as noted by the asterisk in the top row of Table 7). This study supports the hypothesis that identifying and treating the MEP fluctuation factor may provide tinnitus relief from a predominantly cochlear-type tinnitus. Quantitative electroencephalography - power analysis: An electrophysiologic correlate of brain function in subjective idiopathic tinnitus patients. Tinnitus reaction questionnaire-psychometric properties of a measure of distress associated with tinnitus. We hypothesized that tinnitus relief with Clear Tinnitus reflects improvement in the sensory component of the tinnitus complaint by controlling the factor of aeration of the middle ears and improving eustachian tube function.
The designers of Clear Tinnitus have claimed that this blend of homeopathic remedies and herbal medicine, when taken on a daily basis for 3 months, has resulted in significant tinnitus relief [5]. We used quantitative electroencephalography (QEEG) as a monitor at the start and conclusion of the study to identify patterns of electrical activity of brain function hypothesized to reflect tinnitus relief [16]. We performed ultra-highfrequency audiometry using the Tonndorf audiometer for electrical high-frequency audiometry and the Beltone 2000 audiometer for air-conduction high-frequency audiometry. We correlated the physical examination of the tympanic membrane with the tympanometry result. We used within-group repeated-measures analysis of variance (RMANOVA) to assess the differences in the TAI, the TST, the TII, the THI, the stress test, and the depression scale.


The remaining patient dropped out after 1 week in the study because of difficulty in adhering to the regimen, even though subjectively reporting tinnitus relief through the use of Clear Tinnitus.
For 10 of the 11 patients who completed the study, tinnitus location was unchanged; the remaining patient had no tinnitus at the end of the study. Of the remaining three, one with type IV went to type I for both ears; the other two with type IV in both ears went from type IV to type I for one ear and remained at type IV for the other. Two patients with a borderline MEP at the outset that changed to normal reported a positive tinnitus relief outcome, and a single patient with an originally abnormal MEP that changed to borderline also reported positive tinnitus relief. Comparison QEEGs of the seven responders and four nonresponders demonstrated similar patterns. The TST indicated a mean change before and after the study of -4.18, which was not statistically significant.
Owing to small sample size, statistical analysis was limited to univariate and repeated-measures statistical procedures. The correlation of the nonresponders (n = 4) and the responders with the recorded fluctuation in MEP is considered significant. The tympanogram findings of improvement in MEP function in responders is considered to support the hypothesis that improvement in MEP underlies Clear Tinnitus resultant efficacy for tinnitus relief by influencing the transduction mechanism of the middle and inner ear. The similarity of the mean delta QEEG response in the 11 patients and the 7 individual responders and the relative lack of correlation of the delta response to the remaining theta, alpha, and beta find clinical support for consideration that the action of the Clear Tinnitus preparation is predominantly its peripheral MEP effect, with secondary tinnitus relief as reported by the responders, and not specifically its effect on the tinnitus.
No significance appeared in comparing the results of responders to those of nonresponders but, again, this could be owing to the small sample size when separating the patients into independent groups. At the start and conclusion of the study, we performed QEEG testing using a Neurosearch 24 Instrument (Lexicor Medical Technology, Inc., Colorado) to measure objectively a spectral analysis of electrical activity of the brain. Type I masking curves are considered consistent with peripheral tinnitus and type IV with central tinnitus (Table 2). Of the seven responders, two reported no MEP change; one nonresponder also reported no MEP change.
At the conclusion of the study, 10 of the 11 patients had normal to borderline MEPs, and 1 had an abnormal MEP. No significant main effects arose for either changes in the number of abnormal QEEGs over time or the interaction of the EEG band by time. In a comparison of the change in response between responders (n = 7) and nonresponders (n = 4), we observed no significant differences. The THI indicated a mean pre- and post-study change of -11.73, which was not considered to be statistically significant.
In both groups, MEP fluctuation or maintenance of normal pressure was and was not (respectively) correlated with positive tinnitus relief. Significant for this study is the correlation of -100 mm H2O as abnormal with the tympanogram results: Of the seven patients who reported subjective improvement, three went from type C tympanograms to type A. In general, it was hypothesized for this study that an alteration in an original dyssynchronous auditory signal from the peripheral auditory system, resulting from improvement in MEP, and its subsequent effect on the transduction processes of the middle and inner ear, when received by the thalamus, would be synchronized at brain cortex in the form of different brain rhythms.
A reduction in the number of significant delta band recordings occurred over the time course of the study; however, the reduction was not statistically significant. We recommend a larger patient sample over a longer interval of Clear Tinnitus treatment to determine whether the delta rhythm data, although not significant at this time, may reflect a trend of a positive response to therapy when correlated with the remaining theta, alpha and beta frequencies.
For the tinnitus outcome tests that were statistically significant, the key question to be asked is whether the reported tinnitus relief is clinically significant to the patients.
For still others, a combination of these factors or other issues are the goals of treatment. As such, these products will reflect a higher Shipping Weight compared to the unprotected product. We placed an electrode array (consisting of 19 electrodes) on the scalp in a standard international 10-20 pattern [16]. The clinical significance to the patient of reported and recorded tinnitus relief was positive in five patients. Of the remaining three, one with type IV went to type I for both ears, and the other two who were type IV for both ears went from IV to I for one ear and remained type IV for the other. Alterations in the brain rhythms may reflect the efficacy of the Clear Tinnitus for tinnitus relief. The QEEG data suggest that a slightly larger sample size might have changed the outcome of this analysis. Of interest was the response of the seven patients who reported tinnitus relief: When asked whether their relief was "significant," the response was negative for two and positive for five. In any case , the outcome results of this study emphasizes the need for a battery of outcome measures to be included in the evaluation of therapeutic modalities attempting tinnitus relief [13].
We employed a descriptive data analysis method across dimensions of risk to evaluate a base of multidimensional evidence and establish support for our hypothesis. At the conclusion of the 12-week period, we repeated all the audiological tests administered on the initial visit. The analysis compared changes over time in the number of abnormal recordings from the main locations of the scalp recordings (frontal, temporal, parietal, and occipital). This difference, when analyzed by a general linear RMANOVA, was not significant owing to the low power and small sample size. Type I masking curves are considered consistent with peripheral tinnitus and type IV with central tinnitus. Of the four who did not report subjective improvement, three went from type C to type A (one in both ears, the other two in one ear). Efficacy of treatment was hypothesized to be reflected by a reduction in the delta or beta frequencies (or both), a minimal or unchanged theta frequency, and an increase in the alpha frequency. The reduction in the delta response was accompanied by a small increase in the theta response in one patient (not statistically significant at this time). Such a battery of outcome measures should be completed at least at the start and end of the study. A medicalaudiological tinnitus patient protocol completed by each patient identified the clinical type of tinnitus as predominantly cochlear, with a central and middle-ear component bilaterally.
We used the RMANOVA to test changes in the number of abnormal recordings for the 12-week period of the study for the EEG band frequencies delta, theta, alpha, and beta. This lack of significance, due to low power (.336), estimates that there was approximately a 66% chance of missing a significant result for the change in the number of significant recordings over time. We found no statistically or clinically significant correlation of masking curve type to outcomes. Nonresponders with normal MEP and responders with no MEP change provide an inconsistency surrounding the hypothesis. Furthermore, the duration of clinical studies evaluating therapeutic modalities for tinnitus relief should be long-term (at least 6-12 months). We identified fluctuation in middle-ear pressure (MEP) via patients' clinical history, supported by physical examination and established with tympanometry, as a factor influencing the clinical course of the tinnitus in each patient. No significant relationship appeared with the number of reductions of significant QEEG recordings over time and MMLs or LDLs. In the patients reporting tinnitus relief when a tympanogram type A was identified at the start of the study and remained unchanged at the conclusion of the study, the tinnitus relief correlated more with the improvement in appearance of the tympanic membrane and the reported reduced negative MEP than with the tympanogram type (see Table 1). Descriptive data analysis failed to detect any trends in a change in response with audiometric tests across the hearing spectrum; thus, we could derive no coefficients of hearing change.
The Feldmann masking curve comparison at the start and end of the study showed no significant change in the 11 patients. There was no significant alteration in the minimum masking levels or loudness discomfort levels before and after the study. Quantitative electroencephalography analysis revealed a marked difference in the number of significant abnormal recordings between the different frequency bands, with the delta band significantly higher than the theta, alpha, and beta bands for both the overall cohort of patients (n = 11) and those reporting tinnitus relief (n = 7).
The tinnitus outcome questionnaires-the tinnitus intensity index, the tinnitus annoyance index, and the tinnitus reaction questionnaire- revealed a significant difference for the patients (7 of 11) obtaining tinnitus relief. Results of the tinnitus stress test , the tinnitus handicap index, and the measurement of depression scale before and after the study were not statistically significant. Conclusions: Patients who completed the study demonstrated with tympanometry a statistical and clinical significance in MEP improvement or maintenance of MEP (or both). Patients with tinnitus of the severe disabling type selected for this study and responding to Clear Tinnitus reported tinnitus relief accompanied by improvement in or maintenance of MEP of the middle ears.
The statistical and clinical significance of Clear Tinnitus for establishing tinnitus relief remains to be established with a larger cohort of tinnitus patients.



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