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Author: admin, 29.09.2015. Category: Cure Ringing Ears

When you're a family member coping with the hearing loss of a loved one, you may encounter frustration, the feeling of being ignored, separation from the relationship and isolation from daily family life. When a family member has a hearing loss, treated or untreated, the loss impacts the entire family and communication skills are put to the test. DiMarco uses the universal language of dance to change the hearing world’s perception of what it means to be Deaf – and he just might win the Mirrorball trophy in the process.
Late in 2009, researches published a report showing that a newly-discovered type of gene is the cause of a certain kind of early, progressive hearing loss most prevalent in children beginning in infancy.
Researchers in Germany and England have now identified a newly-discovered type of DNA, called microRNA, as the cause of the loss of hearing with a laboratory-proven, genetic basis. Lab results were founded, first, on tests of a new "mouse model" created by German scientists researching genetics in mice.
Now, there are a number of known hearing loss conditions associated with genetic mutations, but researchers have only scratched the surface in analyzing the complex structure of DNA. Researchers at Germany's Helmholtz Zentrum Munchen traced the early loss of hearing to a specific region on the double-helix that forms the structure of DNA.
Labeled miR-96, this gene is responsible for the development of the hair-like structures that line a tiny, snail-shaped organ, called the cochlea, located deep within the inner ear. The cochlea is responsible for converting sound waves into electrical impulses that are then sent to the hearing centers of the brain for interpretation.
Using lab rats, bred to experience genetically-based hearing loss, experiments showed a similar mutation in mouse DNA, offering scientists quantifiable evidence to conclude that, in many instances, early, progressive hearing loss is the direct result of the mutation of a new class of gene – one scientists are just beginning to examine more closely. Perhaps the most remarkable aspect of this study is the discovery of a new class of gene, one that, through mutation in both mice and humans, is the culprit in cases of early loss of hearing. These projections "die" at a faster rate, thus leading to gradual hearing loss and, in the most severe cases, deafness.
In order to correct a genetic defect, researchers first have to identify the cause of a health-related condition like early hearing loss. The research conducted by this international group of distinguished geneticists has provided us with a glimpse of what may someday be possible in the treatment of pediatric, genetically-based hearing loss. Still, this critical research, including the development of a new "mouse model", points scientists in new directions. Rodents and humans working together to find answers to a common, but often poorly understood condition, progressive hearing loss. In a new genome-wide association study, an international team led by neuroscientists from Keck Medicine of the University of Southern California (USC) in Los Angeles has found evidence that some people may be more genetically susceptible to noise-induced hearing loss than others. According to an article in the April 16, 2015 edition of the journal PLOS Genetics, the study authors say that those found to be at higher genetic risk for hearing loss may decide to take additional precautionary measures to protect their hearing prior to noise exposure. According to Keck Med USC, while gene association studies on noise-induced hearing loss in people have been conducted in the past, all were small and their results un-replicated. In the Keck Med USC study, conducted at the Zilkha Neurogenetic Institute, Friedman’s team identified the Nox3 gene—almost exclusively expressed in the inner ear—as a key gene for susceptibility to noise-induced hearing loss.
The study was conducted in collaboration with scientists from Brazil’s Federal University of Rio Grande do Sul, and UCLA. Scientists are continually acquiring greater knowledge regarding the genetics that influence our hearing.


Scientists around the world are constantly working to map out the genetic mutations associated with hearing loss and are frequently making new discoveries valuable for the treatment of hearing loss.
A gene therapy approach can reverse congenital loss of hearing caused by a genetic defect in mice, according to a preclinical study from the University of California, San Francisco.  The findings potentially present a future treatment for people who are born with a hearing loss. Researchers at Washington University School of Medicine have found a single gene which they believe could hold the key to age-related hearing loss. Scientists from the University of Sheffield have partially restored the hearing of deaf gerbils with injections of nerve cells created from human embryonic stem cells.
Unfortunately you cannot use our pictures, as we do not have the copyright, but only have the right to use them on our website. To play the media you will need to either update your browser to a recent version or update your Flash plugin. An enhanced diet helped reduce hearing loss in mice with the genetic mutation most commonly responsible for childhood deafness, new research suggests.
The study found that an antioxidant regimen of beta carotene (precursor to vitamin A), vitamins C and E and magnesium helped slow progression of hereditary deafness in the mice with a connexin 26 gene deletion. Mice in the study received the antioxidant regimen postnatally and in utero in separate experiments. Antioxidants have been shown to reduce the impact of oxidative stress in neuronal disorders, cancer, heart diseases and inflammatory diseases, Miller says. The recent research follows a case study University of Michigan published last year in which the same nutritional supplements were associated with slowing the progression of deafness for a boy with a connexin 26 mutation.
Heredity, either alone or in combination with environmental factors, is the most prominent underlying cause of hearing impairment. Genetic Hearing Loss branches into syndromic and nonsyndromic categorical directions in its coverage of the genetics behind hearing loss. Long-term exposure to loud noise, various diseases like rubella and mumps, sudden loud noises that cause permanent damage to the hearing mechanism, ototoxic medications, certain diseases and of course, aging.
Genes make up DNA, found in every cell, and each set of genes creates the unique individuals we are. Next, scientists in England studied families with histories of early hearing loss, collected DNA samples and found a direct, genetic corollary between hearing loss in lab rats and worsening hearing loss in children. Now, with this latest research, a new kind of DNA, labeled microRNA, is reported, and, well, you start to get an understanding of just how complex the problem is and why research into genetic causes of hearing loss continues.
A specific mutation in something called a "seed region" of the double DNA helix causes gradual, early hearing loss in children. We know this takes years of tireless, dedicated research to find that one genetic sequence within human DNA responsible for the condition. More questions than answers – a good thing in the case of on-going research into genetically-caused hearing loss. Progressive hearing loss affects one in 500 children and this newly discovered gene that affects sensory hair cells of the inner ear may offer future medical interventions. Noise-induced hearing loss is one of the most common work-related illnesses in the United States, according to the National Institute for Occupational Safety and Health (NIOSH), with troops in the Armed Forces being at especially high risk. Genome-wide association studies, or GWAS, search the entire genome for common genetic variants to see if any are associated with a trait.


Using 64 of the 100 strains of mice in the Hybrid Mouse Diversity Panel, the team was able to increase the statistical power of its investigation, leading to the first published GWAS for noise-induced hearing loss in mice. Also, researchers are experimenting with gene therapies which may become essential treatments for hereditary and genetic hearing loss in the future, perhaps in combination with stem cell therapy. When the FGF20 gene was taken out of mice, the animals appeared perfectly healthy, but could not hear at all.
Scientists from Germany and Canada found that an already-known protein also works to protect the ear from permanent noise damage. The procedure may be a first step towards treating deaf people by replacing damaged nerve cells in the inner ear. The only condition is that you provide a direct link to the specific article you use on the page where you quote us. For these childhood cases it’s crucial that we identify therapies that prevent progression and reverse loss of hearing. In the connexin 26 mouse model, the enhanced diet was associated with a slower progression of hearing loss and small but significant improvement in hearing thresholds. Antioxidant treatment has also been shown to preserve gap junctions, which are the cellular components directly impacted by loss of connexin 26.
Thanks in large part to positional cloning techniques, scientists have identified nearly 100 gene loci implicated in hearing loss since 1995-an extraordinarily rapid rate of gene identification. The color of our hair, skin color, eye color, big muscles, tall, short, bald or prematurely gray – all laid out in an incredibly complex genetic map.
Questions provide the road map to discovery, and if a gene mutation is identified as the cause of hearing loss, it may someday be possible to identify and correct the mutation, preventing the onset of a devastating disease. Sleep apnea gets worse post-menopauseFinancial crisis may have caused 500,000 cancer deaths worldwideAre you a workaholic?
In 2013, the Department of Veterans Affairs reported hearing loss as one of the most common disabilities among veterans receiving disability compensation.
Mouse GWAS have led to the discovery of hundreds of genes involved in complex traits that have immediate relevance to people, say the study authors. The study authors say that more research is necessary before clinical recommendations can be made.
In the study, the scientists found that the protein, called AMPK, spurs a mechanism that helps to protect the sensory cells in the inner ear. Noise may come from our work or from voluntary exposure to noise, such as noisy motors or loud music at rock concerts, night clubs, discos and from stereos - with or without the use of headphones.
However, mice with the AUNA1 gene mutation experienced the opposite outcome, showing accelerated progression of deafness following the diet.



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