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What began as a sideline business selling polished metal mirrors to pilgrims in Germany (to capture holy light) evolved into an enterprise that altered the course of art, religion, politics and industry: Johannes Gutenberga€™s movable type and printing press. We judge ourselves by our noblest acts and best intentions, but we are judged by our last worst act. There are 10,000 species of ants, and for several million years they have coved the earth, except Antarctica [no pun intended]. Credit has existed globally since the early days of trading and mercantilism, but it wasna€™t until the 1920s that oil companies issued a physical card to repeat customers who purchased fuel for their new-fangled automobiles. Therea€™s nothing so hollow as the laugh of the person who intended to tell the story himself. CHALLENGE #111: Why is the numeric keypad on a computer (7-8-9 at the top) upside-down from the numeric keypad on phones (1-2-3 on top)? English belongs to the very large Indo-European language family [Germanic, Baltic, Slavic, Celtic, Latin, Hellenic, Iranian, Sanskrit et alia, which led to Polish, Welsh, French, Greek, Kurdish, Punjabi, and English, to name a few].
The real test of character comes when doing the right thing may not be in our self-interest. In the past 5,000 years the human genetic code changed 100 times faster than it had in any prevous period. In the 1880s, Samuel Augustus Maverick was a Texas cattleman who refused to brand his cattle, seeing it as cruel. CHALLENGE #111 was: Why is the numeric keypad on a computer (7-8-9 at the top) upside-down from the numeric keypad on phones (1-2-3 on top)? Researchers gave cash to experimental subjects who were instructed either to spend it on themselves or on others. BIG Q #26: Pericles argued in his Funeral Oration that democracy stimulates excellence because all citizens are stakeholders with public responsibilities.
When intensive-care units at Michigan hospitals followed a 5-step checklist for how to insert intravenous lines in patients, infections were virtually eliminated, saving the hospitals $175 million over 18 months. The peace symbol began as the emblem of the British anti-nuclear movement 50 years ago on Good Friday: a combination of the semaphore positions for N and D [Nuclear Disarmament] within a circle [the earth]. CHALLENGE #114: He was a fighter who was obsessed with boxing and he abused drink and drugs. BIG Q #27: Since poverty is deeper among children than the elderly, why does public spending on the elderly vastly outstrip spending on the young? E-mail and Web searches consume 1.5% of the nationa€™s electricity last year, and if current trends continue, by 2010 the power bill to run a computer over its lifetime will surpass the cost of buying the machine. Biologically speaking, humans have changed little in the 100,000 years [or 3,000 generations] since modern humans emerged on the African savanna--not enough time for serious adjustments.
Rembrandt was a master of chiaroscuro (kee-ahr-uh-SKYOOR-oh), the use of contrasts of light and shade to enhance the depiction of character and for general dramatic effect. CHALLENGE #114 was: He was a fighter who was obsessed with boxing and he abused drink and drugs. CHALLENGE #115: What proportion of the cells in your body are not actually yours but belong to foreign organisms? BIG Q #28: Why do girls, on average, lead boys for all their years in school, only to fall behind in the workplace?
Only 11% of CEOs of top 500 companies have an Ivy League degree, but 20% of the top 60 women in Forbes a€?most powerful womena€? list did. The hormone oxytocin is naturally released in brain after a 20-second hug from a partner, triggering the braina€™s trust circuits. CHALLENGE #115 was: What proportion of the cells in your body are not actually yours but belong to foreign organisms? CHALLENGE #116: A westerner and an easterner who each changed the world, but didna€™t want their names used to identify a religion--to no avail. Featured Quote: a€?The truth of the matter,a€? is that a€?we havena€™t sacrificed one darn bit in this war, not one. BIG Q #29: Why are the most powerful people in the world old white men and pretty young women? When lima bean plants are attacked by spider mites, they release volatile chemicals that summon another species of mites to attack the spider mites. Funeral directors promote embalming: replacing body fluids with formaldehyde, a carcinogen that eventually leaches into the environment when the buried body decays [800,000 gallons annually].
In 2001, President Bush exempted some 3,500 plants that spew toxic chemicals from the Right-To-Know law. Consultants get paid up to $500,000 to name a drug, and insist that letters are imbued with psychological meaning: P, T, and K, they claim, convey effectiveness. CHALLENGE #116 was: A westerner and an easterner who each changed the world, but didna€™t want their names used to identify a religion--to no avail.
CHALLENGE #117: His father a€?bluffeda€? his way into law school using a faked transcript, and went on to finish first in his class and become a successful labor lawyer. Spoken language is instinctual, the brain collects the phonemes and abstracts the rules from what it hears, but written language must be taught.
Busha€™s tax cuts for the rich have reduced annual tax revenue avaiable for public needs by $300 Billion each year.
CHALLENGE #117 was: His father a€?bluffeda€? his way into law school using a faked transcript, and went on to finish first in his class and become a successful labor lawyer. FACTOID: Unusual English spelling shows the way the words were pronounced 100s of years ago. Chinoiserie (sheen-WAH-zuh-ree) is a style of ornamentation using motifs identified as Chinese. CHALLENGE # 118 was: If a tree falls in the forest and no one is there, does it make a sound? CHALLENGE #119: Which a€?booka€™ won the Pulitzer Prize for literature and drama, in successive years? Iodine induces apoptosis and inhibits cells from forming cancer, esophageal varicose Orthoiodosupplementation in a Primary Care PracticeJorge D.
In the better sets, the traditional flaws of plasma (burn-in) and LCD (limited viewing angle, weak blacks, weak fast motion) have been largely eliminated. In 1958, Dinera€™s Club launched the first card available for payment to general merchants: 27 participating NYC restaurants. Kugel, an Orthodox Jew and author of a€?How to Read the Biblea€? says that there is essentially no evidence--archaeological, historical, cultural--for the events in the Torah. Koerner which he said depicts: a€?a horseman determinedly charging up what appears to be a steep and rough traila€?--representing his own political journey against steep odds and naysayers.
The rope was not strong enough to carry them all; they decided 1 had to leave, or all would fall.
According to the Energy Department, vampire gadgets account for about 25% of total residential electricity consumption in the U.S.
Guppy submitted a fish to the British Museum that was already classified, but the name stuck [and the fish is still in a jar at the museum]. But after all, it is the leaders of the country who determine policy, and it is always a simple matter to drag the people along, whether it is a democracy, or a fascist dictatorship, or a parliament, or a communist dictatorship.
No man spoke, but the woman said she would voluntarily let go of the rope, because, as a woman, she was used to giving up everything for her husband, kids and men in general, and was used to always making sacrifices with little in return. The EndHEADLINES FROM THE YEAR: 2059 Ozone created by electric cars now killing millions in the seventh largest country in the world, Mexifornia, (formerly California)White minorities still trying to have English recognized as Mexifornia's third language. So, plasma has truer color and does better in darker rooms, and LCD has more vivid color and does better in bright rooms. My medical practice is situated in the Appalachian Mountains close to Asheville, North Carolina. But, therea€™s no such thing as a 1080p TV broadcast (cable, satellite, anything), and wona€™t be for years.
Actually, it was an illustration for a Saturday Evening Post short story, a€?The Slipper Tongue,a€? about a slick-tongued horse thief fleeing a lynch mob. All you have to do is to tell them they are being attacked, and denounce the pacifists for lack of patriotism and exposing the country to danger. Athens, to honor god of wine & drama, Dionysus [Baccus], where comic actors wore padded phalluses as part of their costumes.
One of the major problems that we encounter in this location is a problem with hypothyroidism. Both of these studies were done at separate times by separate groups showing the exact number of 11.7%. Postal Service raises price of first class stamp to $17.89 and reduces mail delivery to Wednesday only. This reinforces what we were taught, that iodine deficiency goes hand in hand with the manifestation of hypothyroidism.
I have on a weekly basis at least one phone call from a healthcare practitioner questioning whether the intake of iodine causes hypothyroidism and goiter. I often have to go back over the basics of thyroid physiology with these healthcare practitioners, and explain to them that iodine is essential for normal thyroid functions and that it is the manmade organic forms of iodine that are toxic (3).

Global cooling blamed for citrus crop failure for third consecutive year in Mexifornia and Floruba.
I have been using iodine supplementation in my practice over the last four years in amounts needed for whole body sufficiency (orthoiodosupplementation). Orthoiodosupplementation is the daily amount of iodine required for whole body sufficiency (3-5).
Prior to implementing orthoiodosupplementation, I perform a complete history and physical examination.
If a mass is picked up on physical then another test that I order is an ultrasound of the thyroid. While undergoing ultrasound to evaluate the mass I will have my technician measure the thyroid volume.
Each lobe will have its length measured in centimeters, width measured in centimeters and height measured in centimeters. All three measurements are multiplied times each other and this gives the volume in cubic centimeters.
A volume size of 5 cc or less is suggestive of thyroid atrophy, another manifestation of iodine deficiency.
Any solid mass that is picked up on ultrasound and shows itself to be greater in size than one centimeter by one centimeter will require a radioactive I-123 uptake and scan.
This test should be done previous to starting any patient on iodine if a nodule is suspected. A nodule that does not pick up radioactive iodide is considered to be a cold nodule and would suggest the presence of thyroid cancer. Malignant tumors derived from the follicular epithelium are classified according to histological features. The incidence of thyroid cancer is approximately nine per 100,000 in the population per year and this usually increases with age plateau after about age 50. Thyroid cancer at a young age (less than 20) or in older people (greater than 65) is usually associated with a worse prognosis.
Additional important risk factors include a history of childhood head or neck irradiation, large nodule size greater than four centimeters, evidence for local tumor fixation or invasion into lymph nodes, and the presence of metastasis.
In my small practice of around 5,000 patients, I have found five thyroid cancers in one year. If multiple nodules of the thyroid gland are found at the time of ultrasound then the diagnosis of multinodular thyroid goiter is considered even if the gland is normal in size. I request serum T4 (the main hormone produced by the thyroid), free T3 (the biologically active thyroid hormone at the cellular level) and a thyroid stimulating hormone (TSH) level.
Following orthoiodosupplementation, serum T4 and TSH levels usually go down and free T3 stays steady.
I have seen TSH sometimes go up rather than down while T4 and free T3 did not change or may have gone up some. This does not mean that the patient was developing hypothyroidism but that the brain was stimulating the body to make more sodium iodide symporters (NIS). The NIS are channels in the cell membrane that transport atoms into a cell as compared to a calcium channel or a sodium channel or a chloride channel where the channel only admits one atom to go through. The NIS transports sodium iodide into cells and has been found in all cell lines tested so far. Thyroid stimulating hormone, prolactin and oxytocin have been found to stimulate the making of NIS. While taking iodide, one may see an elevated TSH but we have to recognize that this is not a bad thing. Often a check of the patient’s T4, free T3 and TSH shows the T4 to go down, free T3 going down and TSH going up.
The nutritional status of the patient will determine its response to orthoiodosupplementation (3).
It is crucial that the thyroid gland has plenty of antioxidants in its cells and many other nutrients.
We have found that giving a multivitamin for women with PMS (Optivitea ) improves the response to orthoiodosupplementation. Iodine deficiency causes fibrocystic breast disease (FBD) with nodules, cyst enlargement, pain and scar tissue.
Initially, this syndrome occurs in the premenstrual phase of a cycle or involves the whole cycle. In 1928 an autopsy series reported a three percent incidence of FBD, whereas in 1973 an autopsy report quoted an 89% incidence.
A review by the American Academy of Pathology gives a minimum incidence for FBD of 50% but suggests that 80% of North American women are afflicted with the syndrome during their reproductive lifetime. He was able to develop a protocol and a scoring system that helps doctors assess how severe a woman’s FBD is.
I would recommend that this scoring system be utilized by physicians in their own medical practice.
A precise method of recording the patient’s data will help both physicians and patients see the improvement that occurs following orthoiodosupplementation.
The pathological changes that can occur in FBD are noted as micronodularity, tenderness, fibrous tissue plaques, macrocysts and turgidity. For example if the micro nodularity of macrocysts disease was present in the upper half of the breasts the numerical score would be one for micro nodularity and two for the two breast quadrants scoring a total of three.
If all five changes occurred in all quadrants in one breast the score would be 4 (all four breast quadrants) x5 (all five changes) equals 20 and for both breasts would be 40. Patients are also encouraged to evaluate their own symptomology as expressed by a number of zero equals symptoms worse, one equals symptoms unchanged, two equals less pain only premenstrual discomfort, three equals no pain unable to predict menstruation.
Zero equals no palpable abnormalities normal, one equals is score of less than 7.2 and a score greater than 7 but less than the pretreatment score and three equals a score greater than the pretreatment score (See Table I).
After a full year at 50 mg iodine per day (4 tablets of Iodorala ), the patients mean score dropped to 3.8. The other findings of micronodularity, tenderness, fibrous tissue plaques, macrocysts and turgidity will take almost a full year to fully go away. WITNESS: Getting laid ____________________________________________ ATTORNEY: She had three children, right? Optimum amount for most patients for FBD is 50 mg (4 tablets) per day continued indefinitely. It was while treating a large 320-pound woman with insulin dependent diabetes that we learned a valuable lesson regarding the role of iodine in hormone receptor function. She was then started on insulin during her hospitalization and was instructed on the use of a home glucometer. Two weeks later on her return office visit for a checkup of her insulin dependent diabetes she was informed that during her hospital physical examination she was noted to have FBD. One week later she called us requesting to lower the level of insulin due to having problems with hypoglycemia.
She was told to continue to drop her insulin levels as long as she was experiencing hypoglycemia and to monitor her blood sugars carefully with her glucometer.
Four weeks later during an office visit her glucometer was downloaded to my office computer, which showed her to have an average random blood sugar of 98. I praised the patient for her diligent efforts to control her diet and her good work at keeping her sugars under control with the insulin. She then informed me that she had come off her insulin three weeks earlier and had not been taking any medications to lower her blood sugar. When asked what she felt the big change was, she felt that her diabetes was under better control due to the use of iodine. Two years later and 70 pounds lighter this patient continues to have excellent glucose control on iodine 50 mg per day.
We since have done a study of twelve diabetics and in six cases we were able to wean all of these patients off of medications for their diabetes and were able to maintain a hemoglobin A1C of less than 5.8 with the average random blood sugar of less than 100. All diabetic patients were able to lower the total amount of medications necessary to control their diabetes.
The one insulin dependent diabetic was able to reduce the intake of Lantus insulin from 98 units to 44 units per day within a period of a few weeks.
If C-peptide is absent then we feel there is no insulin being produced and we have not been able to help this particular group of patients to get off their insulin. We have been able to help these patients lower the total amount of insulin needed to control their glucose. When patients take between 12.5 to 50 mg of iodine per day, it seems that the body becomes increasingly more responsive to thyroid hormones (3-5). Clur (17) has postulated that iodization of tyrosine residues in the hydrophobic portion of these receptors normalize their response to the corresponding hormone. Optimal intake of iodine in amounts two orders of magnitude greater than iodine levels needed for goiter control may be required for iodization of these receptors (4).
The insulin receptor tyrosine kinase plays a major role in signal transduction distal to the receptor as the primary event leads to subsequent phosphorylation of cytoplasmic proteins, called insulin receptors substrate proteins (IRS).

The IRS proteins are cytoplasmic proteins, with multiple tyrosine phosphorylation sites, and phosphorylation of IRS proteins has been implicated as the first post receptor step in insulin signal transmission. Important Women's Health Issue:* Do you have feelings of inadequacy?* Do you suffer from shyness?* Do you sometimes wish you were more assertive?* Do you suffer exhaustion from the day to day grind? If you answered yes to any of these questions, ask your doctor or pharmacist about Margaritas.
I have one patient with liver fatty infiltration who had varicosities of the esophagus with bleeding. Margaritas are the safe, natural way to feel better and more confident about yourself and your actions. Once she started on iodine for FDB we noticed that her GI bleeding stopped and the varicose veins of her stomach and esophagus disappeared.
Margaritas can help ease you out of your shyness and let you tell the world that you're ready and willing to do just about anything. You will notice the benefits of Margaritas almost immediately and with a regimen of regular doses you can overcome any obstacles that prevent you from living the life you want to live. At its worse this ovarian pathology is very similar to that of polycystic ovarian syndrome (PCOS).
Shyness and awkwardness will be a thing of the past and you will discover many talents you never knew you had. The patients have successfully been brought under control with the use of 50 mg of iodine per day. Control with these patients meaning cysts are gone, periods every 28 days and type 2 diabetes mellitus under control. Ideally, all patients should have an iodine loading test prior to orthoiodosupplementation. This test is one in which 50 mg of iodine is given after discard of the first morning void.
All urine is collected for the next 24 hours including the first morning urine void the next day.
The lab is a CLIA approved high complexity testing laboratory in the state of North Carolina. The next time you are washing your hands and complain because the water temperature isn't just how you like it, think about how things used to be. Here are some facts about the 1500s: Most people got married in June because they took their yearly bath in May, and they still smelled pretty good by June. The majority of the loading tests that are performed at FFP Lab are on women ages 31 – 70 years old.
In 667 patients analyzed, the mean level of excretion was about 18 mg for all age groups no patient achieved whole body sufficiency prior to orthoiodosupplementation. This suggests that of a total 50 mg of iodine given, the patients on the average retained a mean of 32 mg into their body on the first go around. The man of the house had the privilege of the nice clean water, then all the other sons and men, then the women and finally the children.
Following orthoiodosupplementation, patients have described vivid dreams, dissipated depression, no more cold extremities, more energy and less fatigue. Hence the saying, "Don't throw the baby out with the Bath water!" Houses had thatched roofs-thick straw-piled high with no wood underneath . One patient after taking four pills of iodine lost eight pounds of fluid weight in 24 hours. It was the only place for animals to get warm, so all the cats and other small animals (mice, bugs) lived in the roof. Patients who have been constipated for over ten years have now noted daily bowel movements. Hence the saying "It's raining cats and dogs." There was nothing to stop things from falling into the house. This posed a real problem in the bedroom where bugs and other droppings could mess up your nice clean bed. After treating over 1,000 patients with iodine, I have at no time seen the Wolff-Chaikoff Effect. Hence the saying, "Dirt poor." The wealthy had slate floors that would get slippery in the winter when wet, so they spread thresh (straw) on floor to help keep their footing. Goiter is associated with breast cancer, stomach cancer, esophageal cancer, ovarian cancer and endometrial cancer . As the winter wore on, they added more thresh until, when you opened the door, it would all start slipping outside.
I feel that those patients with the lowest excretion rates and the highest absorption of iodine on the iodine loading test are the ones with the highest risk for development of cancer.
From literally hundreds of phone interviews with patients over the last two years, the levels of iodine excretion that seem to raise the highest alarm are those in which the excretion is somewhere around 10 mg or less per 24 hours in patients age 35 and up.
My observations at this point show that there is a definite increase in the incidence of breast cancer, stomach cancer, ovarian cancer or thyroid cancer.
If a patient has the iodine loading test and has an iodine excretion of 10 mg or less in a 24-hour period, I initiate a cancer workup.
In 1976, a JAMA article showed that 6% of the female population was at risk for breast cancer (25)). They would eat the stew for dinner, leaving leftovers in the pot to get cold overnight and then start over the next day. Hence the rhyme: Peas porridge hot, peas porridge cold, peas porridge in the pot nine days old.
It was a sign of wealth that a man could, "bring home the bacon." They would cut off a little to share with guests and would all sit around and chew the fat.
Food with high acid content caused some of the lead to leach onto the food, causing lead poisoning death. This happened most often with tomatoes, so for the next 400 years or so, tomatoes were considered poisonous.
Workers got the burnt bottom of the loaf, the family got the middle, and guests got the top, or the upper crust. Trends and Public Health Implications: Iodine Excretion Data from National Health and Nutrition Examination Surverys I and III (1971-1974 and 1988-1994).
They were laid out on the kitchen table for a couple of days and the family would gather around and eat and drink and wait and see if they would wake up. So they would dig up coffins and would take the bones to a bone-house, and reuse the grave. When reopening these coffins, 1 out of 25 coffins were found to have scratch marks on the inside and they realized they had been burying people alive.
So they would tie a string on the wrist of the corpse, lead it through the coffin and up through the ground and tie it to a bell.
I thought I saw an eye doctor on an Alaskan island, but it turned outto be an optical Aleutian .3. A rubber band pistol was confiscated from algebra class, because itwas a weapon of math disruption.5. It's important to have a woman, who helps at home, who cooks from time to time, cleans up and has a job. It's very, very important that these four women do not know each otherNew Tests For Long Term Care During a visit to my doctor, I asked him, "How do you determine whetheror not an older person should be put in an old age home?" Well," he said, "We fill up a bathtub, then we offer a teaspoon, a teacup and a bucket to the person to empty the bathtub." Oh, I understand," I said.
Bartenders Ever since I was a child I've always had a fear of someone under my bed at night.
Clur, A., DI-Iodothyronine as Part of the Oestradiol and Catechol Oestrogen Receptor – The Role of Iodine, Thyroid Hormones and Melatonin in the Aetiology of Breast Cancer. I was so happy to have saved all that money that I went and bought me a new pickup!' 'Is that so!' With a bit of an attitude he said, 'and how, may I ask, did a bartender cure you?' 'He told me to cut the legs off the bed! Measurement of urinary iodide levels by ion-selective electrode: Improved sensitivity and specificity by chromatography on anion-exchange resin. Here's how the scam works: Two seriously good-looking 20-21 year-old girls come over to your car as you are packing your shopping into the trunk. They both start wiping your windshield with a rag and Windex, with their breasts almost falling out of their skimpy T-shirts. When you thank them and offer them a tip, they say 'No' and instead ask you for a ride to McDonald's. Then one of them climbs over into the front seat and starts crawling all over you, while the other one steals your wallet. I had my wallet stolen March 4th, 9th, 10th, twice on the 15th, 17th, 20th,24th & 29th. Writer Samuel Clemens took the term for his pen name after a stint as an apprentice river pilot.

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