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It’s normally safe to assume that any pill promising weight loss is, at best, a gimmick. As it turns out, the Food and Drug Administration has approved four prescription medications for weight loss in the last three years: Qsymia, Belviq, Contrave, and Saxenda.
Having excess fat on your frame can actually disrupt the hunger signals in your brain, he says, so that you feel hungrier than other people do.

In clinical trials, the drugs helped most people lose about 5% of their body weight or more. They address the obvious, but frequently overlooked, problem that keeps many people fat: Genuine hunger. They just prevent you from feeling starving and miserable while you cut back, which makes the effort more sustainable, he says.
But Dr Nadolsky has seen more dramatic results in his practice, he says, with some patients dropping up to 100 pounds.

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