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30.11.2014
You may be a good candidate for a weight-loss medication if you have a body mass index (BMI) higher than 30, which is considered obese.
In some cases, health conditions other than obesity influence which medication your doctor will prescribe.
As a general rule, you must lose at least 5 percent of your weight within three months in order to keep taking a particular weight-loss drug. Because weight-loss medicines have not proven dramatically effective, and because some new medicines have caused serious health problems, many doctors think it is a pipe dream to believe we will ever have a drug that safely and powerfully helps us to lose weight. Managing Your Cholesterol offers up-to-date information to help you or a loved one keep cholesterol in check. Harvard Health Publications is the publishing division of Harvard Medical School, providing the general public with authoritative, trustworthy, and accessible health information.
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The contents displayed within this public group(s), such as text, graphics, and other material ("Content") are intended for educational purposes only. If you think you may have a medical emergency, call your healthcare provider or 911 immediately.
The information you share, including that which might otherwise be Protected Health Information, to this site is by design open to the public and is not a private, secure service. Everyone seems to have questions like do weight loss drugs & supplements work, are they safe, and if so, how do they work.
Dietary Supplements: These are not approved by the FDA and hence are not tested in clinical trials. Suppressing Appetite: Most weight loss drugs work by suppressing the appetite and thereby reducing food intake. An example is Meridia (sibutramine), which is the only drug approved by FDA for long-term use. Altering food absorption: These reduce weight by preventing the absorption and digestion of fat in foods.
Alli (Orlistat) which prevents fat absorption is the only over- the-counter drug approved by the FDA to treat obesity . Increasing Energy expenditure: These drugs (called thermogenics) help by increasing your metabolism or energy expenditure. Weight loss drugs work best when complimented with lifestyle modifications like diet and exercise. Weight loss drugs cannot cure weight problems; get off the drug, and you will gain all the weight back. I didn’t know the difference between dietary drugs and supplements, thanks for answering my questions! I think most people think that weight loss drugs works via some magic mechanism so they can still eat all the food they are eating and lose weight if they are on it. Exercise Biology stands far part from other fitness sites by taking an evidence-based approach to common man's health, fitness, nutrition & building muscle.
A new weight-loss pill that many doctors consider the most effective of a new generation of anti-obesity drugs got the approval of the Food and Drug Administration on Tuesday.


The pill, called Qsymia, was approved for patients who are overweight or obese and also have at least one weight-related condition such as high blood pressure, diabetes or high cholesterol. The drug offers hope for those who have failed to lose weight in other ways, but its path to approval also underscores how difficult it has been for drugmakers to find obesity treatments that are safe and effective.
The drug's maker, Vivus Inc., said it plans to bring the drug to market in the fourth quarter of this year.
In testing, the drug made led patients to lose more weight than two other weight-loss pills recently review by the FDA. Despite its impressive performance in clinical trials, Qsymia is not exactly a scientific breakthrough.
Phentermine is a stimulant that suppresses the appetite, and has long been used for short-term weight loss.
Researchers say the innovation of Qsymia lies in targeting more than one of the brain signals that drive people to overeat. Qsymia is the second weight-loss drug approved by the FDA in less than a month, following Arena Pharmaceutical's pill Belviq in late June.
The FDA's approvals of Qsymia and Belviq suggest a new willingness to make weight-loss medications available, even in the face of lingering safety issues. The FDA initially rejected Vivus' drug in 2010 over concerns that it can cause birth defects if taken by pregnant women. The agency also said patients with recent or unstable heart disease or stroke aren't good candidates for the drug because its effect on heart rates in those patients is not known. Analysts estimate the new pill could garner more than $1 billion in sales by 2016, though Mountain View, Calif.-based Vivus plans a slow rollout. Kennedy explains that primary pulmonary hypertension is a dangerous side effect of these weight-loss drugs. Note that DISQUS operates this forum and you must log-in or register with DISQUS to participate.
On average, they help people lose about 5 percent of their body weight over a period of six to 12 months. If you don’t, your doctor may prescribe a different drug, or a combination of two or more drugs. Scientific research in the past 20 years has made major advances in understanding the body chemistry that controls weight and appetite. Anthony Komaroff is a practicing physician, Professor of Medicine at Harvard Medical School, and Editor in Chief of Harvard Health Publications. The Content is not intended to substitute for professional medical advice, diagnosis, or treatment.
Any mention of products or services is not meant as a guarantee, endorsement, or recommendation of the products, services, or companies. The drug is actually a combination of two older drugs long known to help with weight loss: phentermine and topirimate. Topiramate is an anticonvulsant, sold by Johnson & Johnson as Topamax, that makes people feel more satisfied after eating. The cocktail of phentermine and fenfluramine was a popular weight-loss combination prescribed by doctors, though it was never approved by the FDA.


In 2010, Abbott Laboratories withdrew its drug Meridia after a study showed it increased risks for heart attack and stroke.
The agency laid out a risk-management plan Tuesday specifically designed to minimize the chance of the women becoming pregnant while using the drug. Company executives say their initial marketing efforts will focus on obesity specialists, not general doctors. However, FDA regulators ordered the company to change the name to avoid potential confusion with similar-sounding drugs. It’s the first time in almost 13 years that the FDA has approved any new drug for long-term weight loss. John Kennedy and Elaine Morrato, an associate professor in health systems, management and policy with the Colorado School of Public Health, join Dr. Diet and exercise are always the first steps toward controlling excess weight and other heart disease risk factors. It wouldn’t surprise me if that research leads to powerful and safe weight-loss drugs in the next 20 years. Always seek the advice of your healthcare provider with any questions you may have regarding your medical condition.
What you have written may be seen, disclosed to, or collected by third parties and may be used by others in ways we are unable to control or predict, including to contact you or otherwise be used for unauthorized or unlawful purposes. The company said patients on the strongest formulation tested lost nearly 11 percent of their weight. But a long line of prescription diet pills have been associated with dangerous side effects, particularly heart problems. It recommends that women of childbearing age test negative for pregnancy before starting the drug and take a monthly pregnancy test while taking it. A third California drugmaker, Orexigen Therapeutics Inc., is still running clinical trials of its product, Contrave, and is working toward an FDA approval date in 2014.
When lifestyle changes aren’t enough, doctors often prescribe medications, like statins for high cholesterol. Finally, you may need weight-loss drugs if you are overweight and have been unable to lose weight despite eating a healthy diet and exercising regularly. On the other hand, a person with a fast heartbeat shouldn’t take phentermine (Adipex-P, Ionamin).
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