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The first of three new diet drugs -- Vivus (VVUS)'s Qnexa -- comes up for a vote at the FDA on July 15, and its fate will send a strong signal about the likelihood of its two rivals (Arena (ARNA)'s lorcaserin and Orexigen (OREX)'s Contrave) also getting a thumbs up. The feds almost unanimously kicked out Boehringer Ingelheim's flibanserin, a re-purposed antidepressant for female libido, on both safety and efficacy grounds even though the drug did not display any particularly worrying side effects. As all three diet drugs have either safety or efficacy concerns, the chances of any of them getting the green light seem reduced.
Vivus's Qnexa: is a combination of phentermine (a bit like speed) and the anti-seizure drug topiramate, commonly known as Topamax. Arena's lorcaserin: This is a new drug and so much less is known about it than the combinations of existing drugs that the other two companies are proposing.
Orexigen's Contrave: is a combination of naltrexone, used to fight alcohol and drug addiction (as Vivitrol), and the antidepressant bupropion.
Safety: "Seven serious adverse events were attributed by investigators as possibly related to Contrave treatment.
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The drug addiction was no secret—after initially claiming he went into rehab to treat an addiction to Ambien, he came clean about the truth depth and scope of his drug use on his 2010 album Recovery. He went deeper into the subject during his appearance in the 2013 documentary How To Make Money Selling Drugs, admitting that his reliance on prescription pills, including, Vicodin, Ambien and Valium, led to his near death after progressing to methadone.
Eminem said he started taking methadone after a dealer told him it was “just like Vicodin, but easier on the liver,” and he continued taking it right up till he overdosed on the heroin substitute in December 2007. Not surprisingly, that was the wake-up call he needed, but after years of serious drug abuse, Em had worn a hole in the lining of his stomach, and he had attempted to fill that hole by binging on fast food, so, to say he was in a bad way physically would be somewhat of an underestimation.
After finally getting clean, Eminem, real name Marshall Bruce Mathers III, channeled his addictive personality away from drugs and towards exercise, leading to his recent drastic weight loss and gaunt appearance.
When I got out of rehab, I needed to lose weight, but I also needed to figure out a way to function sober. I would get up in the morning, and before I went to the studio, I would run eight and a half miles in about an hour. After finally coming to the realization that he was going totally over-the-top, Em eventually chilled the fuck out and switched to a slightly more regular workout regime. He now mixes it up with free weights, bench, and pull-up bar, in a workout called the ‘Body Beast” and, although it’s a much healthier level of working out, he admits it’s still somewhat of an addiction. It is very simple that Weight loss medications or weight loss therapies are used to reduce the increased weight or obesity. Weight gain can be a natural result of fluctuations in hormonal processes, such as the menstrual cycle or pregnancy. Healthcare providers often measure body fat by calculating body mass index (BMI) using an obesity calculator which better known as a BMI calculator. Slow and steady weight loss of no more than 1-2 pounds per week is the safest way to lose weight.

Any weight gain which is caused by emotional problems may be treated by psychological counseling. Belviq, a weight-loss drug from Arena Pharmaceuticals, was approved by the Food and Drug Administration in 2012. Originally published on January 8, 2015 7:07 am In December, the Food and Drug Administration approved a new obesity drug, Saxenda, the fourth prescription medicine the agency has given the green light to fight obesity since 2012. Bessesen commented on studies that reported weight loss dropout rates as high as 46% at the 12-month mark. Like other experts, Bessesen said it's time to treat obesity like other chronic conditions, such as diabetes. Disclosure: Daniel Bessesen, MD serves on the Data Safety Monitoring Board for EnteroMedicsA®, Inc.
The mood surrounding lifestyle drugs has darkened at the FDA, suggesting that all three may get rejected. The warnings for Topiramate include kidney stones, suicide and a type of ammonia poisoning. Two boxed warnings equals two red flags, surely, especially for patients whose cardiovascular systems are already under stress from excessive weight. I feel like if I step away from it for too long, if I have a crazy week and take a five-day break, it’ll be like starting over. Weight gain can also be a symptom of a number of disorders affecting any of several body systems, including the endocrine, cardiac, urinary, neurologic, and respiratory systems.
Increased weight gain or obesity is reflected with some dangerous symptoms other than just looking fat.
Try to stop having medications that can cause weight gain include birth control pills, corticosteroids and medications used to treat bipolar disorder, schizophrenia, and depression.
Other than dieting and physical activity weight gain can be controlled by weight loss pills which generally reduce the craving of food and increased appetite such as Adipex, Bontril, and Phentermine etc. With the agency's approval of Saxenda in December, there are four new weight-loss pills available. But even though two-thirds of adults are overweight or obese, there's a good chance their insurer won't cover Saxenda or other anti-obesity drugs.
According to Daniel Bessesen, MD, Professor of Medicine at the University of Colorado, School of Medicine, "Patients want weight loss medications, but not long-term." Dr. Like other experts, he proposes a new paradigm, thinking of prescription weight loss medicines as a treatment for a chronic conditiona€” obesitya€”similar to how physicians treat hypertension, hyperlipidemia and diabetes. In a study of abuse potential, Arena says the drug has low abuse potential, but it tested lorcaserin against Ambien (a sleeping pill controlled by the DEA) and ketamine (a veterinary anesthetic better known as Special K to the nightclub crowd), which doesn't seem like a tough competition to win. The coating on the Vicodin and the Valium I’d been taking for years leaves a hole in your stomach, so to avoid a stomachache, I was constantly eating — and eating badly. I got an addict’s brain, and when it came to running, I think I got a little carried away.

It also increases your chances of developing other problems, such as gallstones and nutrient deficiencies. The material provided here is for informational purposes only and is not to be used for medical advice, diagnosis or treatment. The health benefits of using obesity drugs to lose weight — improvements in blood sugar and risk factors for heart disease, among other things — may not be immediately apparent. Bessesen spoke at ObesityWeek 2015 in Los Angeles about the status of obesity pharmacotherapy. This can be either an increase in muscle mass, fat deposits, or excess fluids such as water. Furthermore, inexperience with prescribing the drugs, as well as lack of time to explain them, may play a role. There are several methods of weight loss available such as dieting, exercise, weight loss pills and so on. Steve Miller, the chief medical officer at Express Scripts, which manages the prescription drug benefits for thousands of companies.
Miller estimates that about a third of companies don't cover obesity drugs at all, a third cover all FDA-approved weight-loss drugs, and a third cover approved drugs, but with restrictions to limit their use. Part of the reluctance by Medicare and private insurers to cover weight-loss drugs stems from serious safety problems with diet drugs in the past, including the withdrawal in 1997 of fenfluramine, part of the fen-phen diet drug combination that was found to damage heart valves. But as the link between obesity and increased risk for Type 2 diabetes, heart disease, cancer and other serious medical problems has become clearer, prescription drugs are seen as having a role to play in addressing the obesity epidemic.
Obesity accounts for 21 percent of annual medical costs in the United States, or $190 billion, according to a 2012 study published in the Journal of Health Economics. The recently approved drugs— Belviq, Qsymia, Contrave and Saxenda—work by suppressing appetite, among other things. In conjunction with diet and exercise, people typically lose between 5 and 10 percent of their body weight, research shows, modest weight loss but sufficient to meaningfully improve health.
The drugs are generally recommended for people with a body mass index of 30 or higher, the threshold for obesity.
They may also be appropriate for overweight people with BMIs in the high 20s if they have heart disease, diabetes or other conditions.
Susan Pisano, a spokesperson for America's Health Insurance Plans, a trade group, says the variability of insurer coverage of obesity drugs "relates to issues of evidence of effectiveness and evidence of safety." Dr. Caroline Apovian, director of the Nutrition and Weight Management Research Center at Boston University, says many of the patients she treats can't afford to pay up to $200 a month out of pocket for obesity drugs.

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