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Orlistat, Xenical & alli diet pills, what relation?Orlistat (Alli and Xenical diet pills), also known as tetrahydrolipstatin, is a white to off-white crystalline powder.
Orlistat (Alli and Xenical diet pills) is primarily used to prevent the absorption of fats from the human diet, hence reducing caloric intake and should be used in combination with a physician-supervised reduced-calorie diet.
In other words: Orlistat (Alli and Xenical diet pills) inhibits the absorption of about 30% of dietary fat using the recommended dosage of 120 mg three times a day, the fat which is not absorbed by the body is excreted undigested. Note: At the standard prescription dose of 120 mg three times daily before meals, Orlistat (Alli and Xenical diet pills) prevents approximately 30% of dietary fat from being absorbed. What special dietary instructions should I follow?Follow the diet program your doctor has given you.
Xenical Indication and UsageXenical is indicated for obesity management including weight loss and weight maintenance when used in conjunction with a reduced-calorie diet. What NOT to take with Orlistat (alli & Xenical) Absorption of fat-soluble vitamins and other fat-soluble nutrients is inhibited by the use of orlistat.
Orlistat may reduce plasma levels of cyclosporin, an immunosuppressive drug frequently used to prevent transplant rejection; the two drugs should therefore not be administered concomitantly. Review all medications that you are taking with your health care provider, including those that you take without a prescription. Pediatric Use: The safety and efficacy of Xenical have been evaluated in obese adolescent patients aged 12 to 16 years.
You should also follow a program of regular physical activity or exercise while you are taking orlistat. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. In 12 normal-weight subjects receiving Xenical 120 mg three times a day for 6 days, Xenical did not alter the pharmacokinetics of a single dose of digoxin. A pharmacokinetic interaction study showed a 30% reduction in beta-carotene supplement absorption when concomitantly administered with Xenical. In 12 normal-weight subjects receiving orlistat 80 mg three times a day for 5 days, orlistat did not alter the pharmacokinetics or pharmacodynamics (blood glucoselowering) of glyburide. In 12 normal-weight subjects receiving Xenical 120 mg three times a day for 7 days, Xenical did not alter the pharmacokinetics of a single 300-mg dose of phenytoin. In a 2-way crossover study of 24 normal-weight, mildly hypercholesterolemic patients receiving Xenical 120 mg three times a day for 6 days, Xenical did not affect the pharmacokinetics of pravastatin. Xenical & Special PopulationsBecause the drug is minimally absorbed, studies in special populations (geriatric, different races, patients with renal and hepatic insufficiency) were not conducted.
In several studies of up to 6-weeks duration, the effects of therapeutic doses of Xenical on gastrointestinal and systemic physiological processes were assessed in normal-weight and obese subjects. In a 3-week study of 32 obese adolescents aged 12 to 16 years, Xenical (120 mg three times a day) did not significantly affect the balance of calcium, magnesium, phosphorus, zinc, or copper. Orlistat (Alli and Xenical diet pills) availabilityIn most areas, such as the United Kingdom, France, and Canada, orlistat is available by prescription only. As of 2007, no generic formulations of orlistat are legally available in the United States. In Australia, orlistat is currently available over-the-counter in 120 mg size (84 capsules to the pack). Despite claims that (Alli and Xenical diet pills) increases the risk of breast cancer amongst clinical trial participants, there is evidence to suggest that the introduction of specific varied preparations containing orlistat, namely the concurrent administration of orlistat and the monoclonal antibody trastuzumab, can actually induce cell death in tumor cells and block their growth.
A 2006 animal study addressed a connection orlistat (alli & Xenical) shares with aberrant crypt foci (ACF), lesions found in the colon which are believed to be one of the earliest precursors of colon cancer. Xenical is the Roche brand name of the active ingredient Orlistat as mentioned in the review above. I have been taking the prescription form of Alli called Xenical, once those prescriptions are done. I've been thinking about giving alli a go but was kinda skeptical because of the warnings and nasty alli side effects talks here and there. No.Roche,the manufacturer of orlistat Xenical, has clearly stated that Xenical has NOT been studied in pediatric patients below the age of 12 yearsAnyway, you have to consult your kids' pediatric adviser or doctor even if your kid is older than 12 years old. Hi, my aunt is thinking about thaking this drug but she is worried about her metabolism being slow after she stops taking the pills.
For me, Alli was not a big story, I had some bad side effects, namely passing blood in my stool, I don't know the reason.

A golden rule I read it in an article:"You have to eat a reduced-calorie, low-fat diet and be willing to do the work. Orlistat is practically insoluble in water, freely soluble in chloroform, and very soluble in methanol and ethanol. Orlistat is marketed by Roche under the trade name Xenical, and as an over-the-counter under the name alli by GlaxoSmithKline. It exerts its therapeutic activity in the lumen of the stomach and small intestine by forming a covalent bond with the active serine residue site of gastric and pancreatic lipases. As undigested triglycerides are not absorbed, the resulting caloric deficit may have a positive effect on weight control. You should evenly divide the amount of daily fat, carbohydrates, and protein you eat over three main meals. Side effects are most severe when beginning therapy, and decrease in frequency with time; in clinical trials, nearly half of side effects lasted less than a week, but some may persist for over six months.
A multivitamin tablet containing vitamins A, D, E, K, and beta-carotene should be taken once a day, at least 2 hours before or after taking the drug. Therefore when being treated with Xenical, take a multivitamin supplement that contains vitamins D, E, K, and beta-carotene.
However, the safety and efficacy of Xenical has not been studied in pediatric patients below the age of 12 years. However, before you start any new activity or exercise program, talk with your doctor or health care professional.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Although undercarboxylated osteocalcin, a marker of vitamin K nutritional status, was unaltered with Xenical administration, vitamin K levels tended to decline in subjects taking Xenical. Postprandial cholecystokinin plasma concentrations were lowered after multiple doses of XENICAL in two studies but not significantly different from placebo in two other experiments. In Australia and the United States, certain formulations of orlistat have been approved for sale without a prescription. Food and Drug Administration advisory panel voted 11 to 3 to recommend the approval of an OTC formulation of orlistat, to be marketed under the name alli by GlaxoSmithKline. Initially available only with a prescription, it was reclassified as a "Pharmacist Only Medicine" in October 2003. I believe the Alli side effect too many people are talking about is true which happens only if you take too much fat while using Alli. Personally, the most noticeable alli side effect I hate is that it may cause gas with oily discharge and uncontrollable diarrhea. Of course you don't have to count calories one by one, but zooming out to watching the kind of food you're eating while on alli.Indeed, it pushes you to be conscious about what you eat, that is if you want to have any success with alli. Before using it, and as Alli manufacturer pretty good stated in their advertisements, I was well aware it is not a "magic pill".
Well if you can use the fear of soiling your pants as your powerful motivator!Now, Let's do some math about Alli pill:Alli makes 25% of the fat you consume with your three daily pills indigestible. If orlistat is taken with a diet high in fat (a diet with more than 30% of the total daily calories from fat), or with one meal very high in fat, it is more likely you will experience side effects from the medication.Orlistat (Alli and Xenical diet pills) blocks your body's absorption of some fat-soluble vitamins and beta carotene. Because orlistat's main effect is to prevent dietary fat from being absorbed, the fat is excreted unchanged in the feces and so the stool may become oily or loose (steatorrhea). The capsules also contain the inactive ingredients microcrystalline cellulose, sodium starch glycolate, sodium lauryl sulfate, povidone, and talc. Take your multivitamin once a day at least 2 hours before or after taking Xenical, such as bedtime.
The effect of orlistat on the absorption of supplemental vitamin D, vitamin A, and nutritionallyderived vitamin K is not known at this time.
Therefore, as vitamin K absorption may be decreased with Xenical, patients on chronic stable doses of warfarin who are prescribed Xenical should be monitored closely for changes in coagulation parameters. There were no clinically significant changes observed in gallbladder motility, bile composition or lithogenicity, or colonic cell proliferation rate, and no clinically significant reduction of gastric emptying time or gastric acidity. Approval was granted on February 7, 2007,and alli became the first weight loss drug officially sanctioned by the U.S.
In late 2006, the Australian Consumers' Association complained that Roche was inappropriately advertising the drug to teenagers, and Roche was forced to withdraw its ads.

If you don't want greasy stuff coming out of your butt, don't put greasy stuff in your mouth, it's that simple.
Namely, "May cause gas with oily discharge and uncontrollable diarrhea." IMO, if someone had an accident, they wouldn't want to tell anyone about it. Frankly I had to do my part as well knowing how to eat and what to eat, although, should I have a craving I eat a very small portion to satisfy me that's it!
I lost 55 pounds, in addition to using Orlistat alli, I've been watching my dieting habits vigorously and exercising regularly at the gym on the treadmill for 35 minutes.Ok! This way I got surprised of how much fat is hidden in our daily diets, even if you prepare your meals your own way.Now, I don't only watch the portion size I eat but more importantly get to know how much fat it contains.
In my own experience, taking alli is a good thing, especially when adding a regular exercise program, which could include just a brisk walk after dinner.
I read here so many people having positive experience with it, but I think Alli is not me, at least for the time being till I see my doctor!
It also requires that you eat no more than 15 grams of fat at these meals if you want to avoid the "treatment effects". At the recommended therapeutic dose of 120 mg three times a day, Orlistat(Alli and Xenical diet pills) inhibits dietary fat absorption by approximately 30%.
Therefore, when you use orlistat you should take a daily multivitamin that contains vitamins A, D, E, K, and beta-carotene. In addition, no effects on plasma triglyceride levels or systemic lipases were observed with the administration of Xenical in these studies.
They would rather have a quick fix pill such as alli or xenical and will put up with the "side effects" that endangers their health integrity. After reading over the Alli material, I realized the Xenical and the Alli are identical (both are Orlistat), however Alli is 60mg per pill (half of Xenical). Even though I was especially careful of what I ate, it still left me with very loose, pungent stools. Therefore, Alli eliminates 25% of 45 grams of fat a day (assuming you eat the max), which is 11.25 grams.
Xenical works by inhibiting the lipase in your digestive system, that is about 30% of fat in your meal is not absorbed into your body and therefore goes straight through you. Bowel movements may become frequent or urgent, and rare occurrences of fecal incontinence have been seen in clinical trials. Consumer advocacy organization Public Citizen, through its Health Research Group, opposed over-the-counter approval for orlistat, calling it "the height of recklessness" and "a dangerous mistake" due to questionable benefits and possible adverse effects. As there are 9 calories per gram of fat, Alli eliminates 100 calories a day from your diet.
Take the multivitamin once a day, 2 hours before or 2 hours after taking orlistat, or take the multivitamin at bedtime.
To minimize these effects, foods with high fat content should be avoided; the manufacturer advises consumers to follow a low-fat, reduced-calorie diet.
My thoughts are get the Alli, and double the dosage to get the same mgs as the Xenical my doc prescribed. Ask your doctor or pharmacist any questions you might have about taking a multivitamin while you are taking orlistat.While you are taking orlistat, you should avoid foods that have more than 30% fat. Oily stools and flatulence can be controlled by reducing the dietary fat content to somewhere in the region of 15 grams per meal. For $106, with Alli, I am getting 180 pills each of 60mg, but by doubling dosage, will have the same mgs, for less money.
When eating meat, poultry (chicken) or fish, eat only 2 or 3 ounces (55 or 85 grams) (about the size of a deck of cards) for a serving. This product is a lifesaver but only works if accompanied with improving eating habits and exercise. When dining out, ask how foods are prepared and request that they be prepared with little or no added fat.

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