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Intravenous aciclovir is effective to treat severe medical conditions caused by different species of herpes virus family includes severe localized infections of herpes virus, severe genital herpes, chickenpox & encephalitis.
Aciclovir is excreted in the breast milk, therefore it is recommended that caution should be used in breast-feeding women. Common adverse drug reactions (?1% of patients) associated with systemic aciclovir therapy (oral or IV) include: nausea, vomiting, diarrhea, encephalopathy (with IV use only), injection site reactions (with IV use only) and headache.
Intravenous aciclovir may cause reversible nephrotoxicity in up to 5% to 10% of patients because of precipitation of aciclovir crystals in the kidney. Ketoconazole: In-vitro replication studies have found a synergistic, dose-dependent antiviral activity against HSV-1 and HSV-2 when given with aciclovir.
Resistance to aciclovir is rare, but is more common in patients on chronic antiviral prophylaxis (transplant recipients, people with acquired immunodeficiency syndrome due to HIV infection).
Acyclovir is poorly water soluble and has poor oral bioavailability (15–30%), hence intravenous administration is necessary if high concentrations are required.

Vince later went on to invent abacavir, an nRTI drug for HIV patients.[39] Elion was awarded the 1988 Nobel Prize in Medicine, partly for the development of aciclovir. Ellagitannins as synergists of ACV on the replication of ACV-resistant strains of HSV 1 and 2.
Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. It is also effective in systemic or traumatic herpes infections, eczema herpeticum and Herpes simplex meningitis.
Aciclovir crystalline nephropathy is more common when aciclovir is given as a rapid infusion and in patients with dehydration and preexisting renal impairment. Infrequent adverse effects include erythema or itch.[6] When applied to the eye, aciclovir is commonly associated (?1% of patients) with transient mild stinging.

Nucleosides isolated from a Caribbean sponge, Cryptotethya crypta, were the basis for the synthesis of aciclovir.[33][34][35] It was codiscovered by Howard Schaffer following his work with Robert Vince, S.
Richard Whitley, a University of Alabama at Birmingham researcher and pioneer in antiviral therapy, was the first to successfully use the drug in humans.
If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Gurwara on the adenosine analog acycloadenosine which showed promising antiviral activity.[36] Later, Schaffer joined Burroughs Wellcome and continued the development of aciclovir with pharmacologist Gertrude B.

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