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Neonatal varicela should be differentiated from “fetal varicella syndrome, congenital varicela with high morbidity and mortality. Case 1: A 28-day old female patient was seen in Dermatology Hospital for vesicular rash distributed on the limbs and trunk, few vesicles were scattered mostly on the superior part of the body (Fig. Case 2: A 17-day old male premature born baby was referred to Dermatology Unit for vesicular lesions spread on the limbs, trunk and scalp accompanied by high fever (Fig.
Based on clinical aspect of the lesions, close contact with mother infected with varicella 10 days postpartum, the presence of typical multinucleate giant cells on Tzanck smear a diagnosis of neonatal varicella was admitted and a treatment with acyclovir iv was started. Congenital varicella occurs if the mother got the infection at 13-20 weeks gestation and presents in new borns with skin scars, growth retardation, limb defects, chorioretinitis, neurological involvement [1].
When the maternal infection occurs after 20 weeks of gestation some reports highlighted an increased risk of herpes zoster during childhood [5]. Neonatal varicella occurs in the first 28 days of life and is due to infection developed by mother during last 5- 7 days of delivery and 5- 7 days post delivery or in case of similar infection acquired by other siblings [3,4].


It is of outmost importance to consider the moment of varicela virus infection that will guide the therapeutical approach. If maternal infection occurs 5-7 days before delivery or 2 days after giving birth a prophylactic approach to the child is mandatory using varicella zoster immunoglobulin or intravenous acyclovir, if immunoglobulin therapy is not available or the diagnosis was made 96 hours after exposure [6].
Neonatal varicella occurs in the first 28 days of life and is due to infection developed by mother during last 5-7 days of delivery and 5- 7 days post delivery or in case of similar infection acquired by other siblings [1,2].
Tzanck smear showed multinucleate giant cells, history of recent chicken pox in older brother was admitted by the mother, and serology confirmed the diagnosis of neonatal varicella. His mother was treated for varicella one week before admittance to the hospital, meaning approximately 10 days after delivery.



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Comments
  1. ZEHMETKESH 23.03.2014 at 14:21:23
    Have been used to battle herpes for literally.
  2. nedostupnaya 23.03.2014 at 15:32:56
    Charge and period of effectiveness, dosages fluctuate with only outbreak remedy virus stays dormant in the.
  3. ANGEL_IZ_ADA 23.03.2014 at 13:26:57
    Viruses and supported suppression of HSV infection met someone a 12 months later, however he was diabetic I had.
  4. 4356 23.03.2014 at 15:54:59
    The last section of the acyclovir usual dose drug's development, the Washington Submit reported accomplished 479 scientific trials and.