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Riboflavin (vitamin B2) galvanizes mitochondrial energy production, which may be deficient in patients with migraine.
CoQ10 is a component of the electron transport chain that maintains mitochondrial energy stores just like riboflavin.
Sometimes, patients with headaches have low magnesium levels, which may potentiate migraine development by decreasing opposition to neuronal excitability. Petasites hybridus, or butterbur shrub, possesses antihistamine, antileukotriene, and calcium channel-modulating effects.
Unlike the rest of the most commonly used CAM products for headache, melatonin is not recommended for migraine or cluster headache. Wick): Up to 82% of patients with headaches turn to complementary and alternative medicine (CAM) for relief, frequently without first consulting a physician.


Riboflavin, coenzyme Q10 (CoQ10), magnesium, Petasites hybridus, feverfew, and melatonin are the most commonly used CAM products for headache. Citing good evidence, the AAN claims that riboflavin is likely effective for migraines in adults. Limited evidence indicates that increased supplemental or dietary magnesium, an N-methyl-D-aspartate (NMDA) receptor inhibitor, may prevent migraine. Since CAM products are exempt from FDA review, information about their safety and efficacy is scarce and often conflicted.
The product also boasts a favorable side effect profile, which consists of rarely occurring diarrhea and polyuria, as well as bright yellow urine. CoQ10 is well tolerated, with anorexia, dyspepsia, nausea, and diarrhea occurring in less than 1% of subjects.


Two studies even reported improved response rates in acute migraine after intravenous magnesium sulfate, particularly for migraine patients with aura. Clinicians should monitor liver function regularly in migraine patients treated with Petasites.



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