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JavaScript is currently disabled, this site works much better if you enable JavaScript in your browser. Researchers at the University of California, San Diego School of Medicine and the UC San Diego Moores Cancer Center have identified a new drug discovery approach enabling the destruction of the most highly proliferative tumors.
RAF has been long-studied, but its role in cell division -- critical to cell proliferation and tumor growth -- was a surprise. Current cancer drugs that target enzymes like RAF are generally designed to interact with the active site of the enzyme.
Cheresh and colleagues pursued development of a new class of RAF inhibitors that do not bind to the active site of the enzyme and so avoid the limitations of current drugs.
KG5 produced similar results in tests on cancer cell lines, in animal models and in tissue biopsies from human cancer patients. The new RAF targeted compounds are being developed by Amitech Therapeutic Solutions, Inc a start-up company in San Diego. Co-authors of the study, all from the departments of Pathology or Radiation Oncology at the UC San Diego Moores Cancer Center, are Ainhoa Mielgo, Laetitia Seguin, Miller Huang, Fernanda Camargo, Sudarshan Anand, Aleksandra Franovic, Sara M. Robert Karul received his doctorate from FiU SAV (Institute of Philosophy of the Slovak Academy of Sciences) and from Universite Paris XII – Val de Marne, where he defended the dissertation thesis on being without a subject, with Emmanuel Levinas as the first reader.
James Thomson graduated in modern history and worked in central and eastern Europe, Africa and the former Soviet Union before joining BBC World Service Radio, where he produced and edited live news programmes for the English-language service. The discovery, published in the November 13 online issue of the journal Nature Medicine, points to an effective, alternative method for killing fast-growing cancer cells without causing some of the negative effects of current therapies. Instead, this new class, called allosteric inhibitors, changes the shape of the target enzyme and in doing so, renders it inactive. The research team has since developed variants of KG5 that are 100-fold more powerful than the original drug. Angelina Mehta is originally from southern California and moved to the North Atlanta area after earning her medical degree in Tempe, AZ. Marine Corps for 10 years, where she had earned many promotions and decorations while gaining experience in teaching, leading and caring through assignments in civilian-military affairs and operations domestically, and abroad while deployed.  She has proven exceptional initiative and drive, which she is determined to utilize infusing vitality to restore health in clients’ lives.
Dana Ahern, MA studied sociology, with specialization in sociology of health and medicine at Boston College. From 2006–2008, he was a fellow of the International Graduiertenkolleg in “Political communication“ (the University of Frankfurt am Main, Innsbruck, Trento).
Karen Henderson was born in London and has degrees from the University of Leicester, the University of London and the University of Bradford in the UK.
He is a scientific researcher at FiU SAV and lectures history of aesthetics at the Academy of Performing Arts. Aliaksei Kazharski (Alaksej Kazarsky) received his PhD from Comenius University in Bratislava (Slovakia) in 2015.
He subsequently lived and worked in Australia and then New Zealand, producing, editing and presenting programmes for Radio New Zealand and Radio New Zealand International.

The specific drug tested, known as KG5, singles out RAF in proliferating cells, but ignores normal or resting cells. They hope one of these more powerful compounds will soon enter clinical trials at Moores Cancer Center.
He is author of five monographs, among them Pozvanie k Heideggerovi (Invitation to Heidegger), Bratislava: and Osud a volba (Fate and Choice.
Prior to BISLA, Dagmar worked in the Slovak Helsinki Committee for Human Rights and served on its Board of Directors. She has worked as a lecturer, dramaturgist and head dramaturgist of the Slovak National Theatre. Prior to that, she has studied Gender Studies at the Central European University (CEU) in Budapest and English and American Studies at the Masaryk University in Brno. A visiting researcher at the Center for Latin American Studies at the University of Chicago (2008) and the Hoover Institution at the Stanford University (2009). She worked for many years as Senior Lecturer in Politics at the University of Leicester, where she specialised on both the domestic politics of the Slovak Republic and EU eastern enlargement, focusing in particular on euroscepticism and the influence of domestic politics on EU decision making. Previously he was a visiting researcher at the ARENA-Center for European Studies, University of Oslo (Norway), the Center for EU-Russia Studies, University of Tartu (Estonia), and the Institute for Human Sciences (IWM) in Vienna (Austria). He studies biblical exegesis at the Biblical Institutte in Rome, Hebews University in Jerusalem and at the Gregorian University in Rome. As well as teaching, he has travelled widely in Slovakia and is the author of an English-language travel guide to the country. Cheresh, PhD, professor of pathology and associate director for translational research at the Moores Cancer Center, used an innovative chemical and biological approach to design a new class of drugs that arrests division in virtually all tumor cells by binding to and altering the structure of an enzyme called RAF. In affected tumor cells, RAF is unable to associate with the mitotic apparatus to direct cell division, resulting in cell cycle arrest leading to apoptosis or programmed cell death. James has been  teaching courses on early modern and twentieth-century political philosophy (Philosophy and Modern Society), Plato’s Republic, and the history of political economy and contemporary agriculture (Business Ethics). In shaping the program of our first theatre scene, she focused on titles that appeared for the first time on a stage in Slovakia, especially anglo-american and original Slovak drama or adaptations of renown works. Since 2005, a member of the Research Group of Studies of the Literary Exile (GEXEL) of the Center of Research of the Dictatorship and Democracy at the Autonomous University of Barcelona, and since 2013, collaborator of the HISPONA Group, University of Santiago de Compostela. Since 2008, he has worked at the Austrian embassy in Bratislava and, since 2009, as a lecturer at BISLA. She has collaborated with BISLA for many years, teaching both comparative and European politics, and has been living in Slovakia permanently since 2014. Currently, he works as a scholar at the Philosophic Institute of the Slovak Academy of Sciences. KG5 in a similar manner effectively interferes with proliferating blood vessels, a process called angiogenesis.
He received a bachelor’s degree in international relations and political economy from the University of Toronto.

Since 2004, Dagmar was the Program Director at the Bostonian International Center for Conciliation, where she remains affiliated as a Senior Fellow and trainer in identity conflicts transformation.  Her primary academic interests include the political use of collective memory, ethnic identity, citizenship and minorities, at present focusing on the manifestations of cultural trauma in public discourse. Her key areas of itnerest are sociology of health and medicine, sociology of disability, gender studies, qualitative sociology as well as the qualitative method in sociology.
Papers published: on Nietzsche, Spinoza, Schopenhauer, Althusser, Rorty, Foucault and Deleuze. In the years 2011-2013, as a fellow of the Four Universities Alliance program, she was a postdoctoral researcher in the Department of Humanities at the Carlos III University of Madrid. He focuses on research into the philosophic legacy of Kierkegaard, the philosophy of the 19th century, the philosophy of religion, and the issue of subjectivity and intersubjectivity. He received his MA from Carleton University in Ottawa in 1990 at the Institute of Soviet and Eastern European Relations. She serves as the country expert on citizenship at the European Democratic Observatory  (at EUI) and co-organizes a global annual Muslim-Jewish Conference. She focuses on social aspects of mental disability, social and gender aspects of eating disorders and the use of alternative, qualitative, and visual methods in sociological research. Her book “The Cultural Cold War and Spanish Republican exile: Papers of the Congress for Cultural Freedom (1953-1965)” is the first monographic study of the activities of the Congress for Cultural Freedom within the anti-Franco opposition in Latin America and Spain.
His thesis discussed the political culture of Czechoslovakia during the period of 1969–1989. She was a member of the Public Against Violence, ministor of labor, social affairs, and family, member of the parliament, and the prime minister of the Slovak Republic. Currently, she takes part in organization of the international festival of the Slovak National Theatre. Co-editor of “Bibliographical Dictionary of the Spanish Republican Exile” (section of magazines and reviews), scheduled to be published in four volumes in late 2014.
He received his doctorate in political philosophy and comparative politics from Carleton University in 2001. In addition to the cultural Cold War, her main interest is the comparative history and theory of European cultural exiles. She has cooperated with the dance theatre Elledanse as a director and dramaturgist and has directed a play Gals on Board and a successful production of a play of A. He is the author of translations, publications, and articles for print and electronic media.
At BISLA, she teaches courses Theatre and Society, and Theatre and Politics since 2010 as external faculty.

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