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During his fight, Carson received multiple chemotherapy and radiation treatments and several blood and platelet transfusions. Makedonka Mitreva is at the Genome Institute and Department of Genetics, Washington University School of Medicine, St.
Every 4 minutes someone is diagnosed with blood cancer and every 10 minutes, blood cancer takes a precious life.
On the day of collection the donor’s blood is removed with a sterile needle from one arm and passed through a machine that separates out the blood stem cells.
While taking the medication, many donors experience flu-like symptoms such as headaches, bone and muscle achiness and fatigue.
Marrow cells are collected from the backside of the pelvic bone (not the spine) using a special syringe. Many donors experience some pain, bruising and stiffness for up to two weeks after their donation. A study of patients with chronic myeloid leukemia (CML) treated with imatinib found that chronic fatigue is the major factor that limits health-related quality of life (HRQOL).


Blast crisis of CML: Peripheral blood smear revealing the histopathologic features indicative of a blast crisis in the case of CML HRQOL has become substantially more important in the treatment of CML, as 5-year survival rates have climbed dramatically with the use of tyrosine kinase inhibitors, such as imatinib.
After four trips to the pediatrician, several examinations, antibiotics, and blood tests, Carson was diagnosed with Acute Lymphoblastic Leukemia. Today, Carson is in remission and doing extremely well thanks to the treatment and lifesaving blood transfusions he received. Schistosome eggs (2) are transmitted in the urine (for urogenital schistosomiasis) or stool (for intestinal schistosomiasis) of infected individuals and hatch into miracidia (3), which infect snails (an intermediate host) (4). When conventional treatments don’t work, the only hope is a bone marrow transplant from a matching donor. To increase the number of stem cells in the bloodstream, donors receive daily injections of a synthetic protein called filgrastim for 4 days before and on the day of the collection. Within a week of donating, most donors are able to return to work, school and many regular activities. The cell collection is an outpatient procedure that takes about 4-6 hours on 1-2 consecutive days.


The cercariae leave the snail, swim freely in the freshwater and infect humans by penetrating the skin.
The researchers analyzed data on 422 CML patients (out of 448 eligible patients enrolled) at 26 centers, all of whom were treated with imatinib; the median treatment time was 5 years.
HRQOL was assessed using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and fatigue was evaluated using the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale.
Fatigue was the only such factor, however, that showed a significant association with all of the physically related scales of the SF-36. For example, patients in the higher fatigue category also commonly (60%) reported severe musculoskeletal pain, while only 4% of those with low fatigue reported that symptom. The authors noted that the magnitude of differences between patients with high vs low fatigue levels was very large.



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