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Figure 2 : Chlamydia pneumoniae [mdash] an infectious risk factor for atherosclerosis? Chlamydial organisms are also a frequent cause of abortions, pneumonia, conjunctivitis, encephalomyelitis, polyarthritis and infertility in livestock. There is no efficacious vaccine to prevent chlamydial infections in either human or animals and there have been no human Chlamydia vaccine trials since the 1960s. Our research has focused on the following goals: (1) understanding the role and mechanism of Chlamydia involvement in chronic respiratory diseases. The bacterium causes infections of the respiratory tract, but also atypical pneumonia that may lead to serious, sometime fatal complications in immunocompromised and elderly people.


Among them are two important human species, Chlamydia trachomatis and Chlamydia pneumoniae. Chlamydiae have been isolated from milk samples and mammary tissues from dairy cows affected by mastitis as well as frozen semen samples. Our lab is using the gas vesicles of Halobacteria as a platform for multi-subunit antigen display and have confirmed that this system is a potentially effective display and delivery platform for antigens of chlamydial vaccine interest. Chlamydial infections in cattle are an emerging economic burden worldwide and infections range from an asymptomatic state with intermittent shedding of the organism, to overt clinical disease and mortality. We are refining a Loop Isothermal Amplification (LAMP) assay that would be amenable to farm use and would not require expensive equipment or technical expertise to perform.


This asthma phenotype is characterized by significant neutrophil infiltration into the airways and recent reports confirm that half of all asthmatics have a non-allergic phenotype that is not well controlled with inhaled corticosteriods treatment. We expect to design an inexpensive kit that farmers could use to test various biological samples for the presence of Chlamydia right in their farm house.



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