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People who take popular heartburn pills known as proton pump inhibitors (PPIs) may be more likely to develop chronic kidney disease than individuals who don’t use these drugs, a study suggests. For the study, Grams and colleagues analyzed two large sets of data to examine the connection between PPI use and kidney disease in the general population. The analysis linked PPI use to an increased risk of chronic kidney disease in both data sets, although PPI users were also more likely than non-users to be overweight or on medication to lower blood pressure or cholesterol. First, the researchers reviewed data on 10,482 people who were part of a study on atherosclerosis, or hardening of the arteries, tracking half of them for more than 14 years. They found 56 incidents of chronic kidney disease among 322 people taking PPIs, compared with 1,382 incidents among 10,160 individuals who didn’t use the pills. In a second analysis, researchers examined data on 248,751 patients in the Geisinger Health System in Pennsylvania, with half of participants followed for at least six years. This time, there were 1,921 incidents of chronic kidney disease among 16,900 PPI users, compared with 28,226 incidents among 231,851 non-users. It’s possible that the PPI users had other risk factors for kidney disease that were unrelated to the medications, the authors acknowledge in JAMA Internal Medicine. Even so, the findings add to growing evidence suggesting that some patients may experience dangerous side effects from PPIs, Dr. Earlier research has linked the pills to kidney damage, heart problems, infections and fractures, they wrote.
Many patients with heartburn and indigestion don’t need PPIs, Schoenfeld added, noting that behavior and lifestyle changes such as getting more exercise and drinking less alcohol may have the same effect as PPIs for mild stomach symptoms. People who take popular heartburn pills known as proton pump inhibitors (PPIs) may be more likely to develop chronic kidney disease than individuals who don't use these drugs, a study suggests.


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Recent articles show the increased risk of Diabetes and poorer Diabetic control with patients taking cholesterol  lowering drugs. Liew’s article from last week in ‘Diabetology and Metabolic Syndrome’ showed that statin users had HBA1c levels (a marker of Diabetes control) 29% higher than non-statin users. If you were already Diabetic then you were also 20.8% more likely to have poorer control of your Diabetes if you were on a statin drug.
Two of the articles state that is still better to be on a statin but did not really qualify that.
My concern is that the poorer blood glucose control directly comes back to insulin resistance and inflammation – and that worries me more than any cholesterol lowering drug. Abigail Adams began her freelance writing career in 2009, teaching others about medical conditions and promoting wellness by writing on online health and fitness publications. Aspirin, also referred to as acetylsalicylic acid, is an anti-inflammatory and analgesic medication that can alter the levels of uric acid in the blood.
Anti-rejection medication, such as cyclosporine, can cause increased levels of uric acid in the blood and raises the risk of developing gout. But earlier studies have also linked the pills to this side effect, and the association is worrisome because tens of millions of people a year take these pills, sold by prescription and over-the-counter in some countries, with brand names including Prilosec, Prevacid and Zegerid.
Dietary and lifestyle changes are significantly better at lowering cardiovascular disease risk factors. She is educated and licensed as a registered nurse, having received her degree from North Georgia College and State University.


If the body has too much purine, due to natural disposition or from eating purine-rich foods, the level of uric acid in the blood rises. These medications work to increase survival of individuals who undergo an organ transplant, such as the heart, kidney and bone marrow.
While scientists aren’t certain how the drugs affect the kidneys, prior research has tied PPIs to a form of kidney inflammation known as interstitial nephritis. Increased levels of uric acid in the blood, also referred to as hyperuricemia, can cause a type of arthritis called gout. As the kidneys pull more fluid out of the body, it increases the risk of uric acid building up due to the decreased ability of the kidney to remove the uric acid. Low doses of aspirin, classified by infrequent use, can cause an increase in the uric acid levels, according to Lab Tests Online, where as large doses of aspirin can decrease the levels of uric acid. The damaged kidney loses the ability to efficiently remove uric acid from the blood, which can cause the uric acid levels to rise. In addition to extra purine in the body, taking certain medications can increase uric acid levels.



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