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America Conference, and serving on the Mycology Research Laboratories scientific advisory board. These guidelines were developed by a panel of specialists from the United States government and academic institutions.
ART drugs, leading to subtherapeutic serum levels and the development of antiretroviral drug resistance. OIs that occur after patients have been started on ART can be categorized into three groups. Physiologic changes during pregnancy can complicate the recognition of OIs and complicate pharmacokinetics.
Increased cardiac output by 30%--50% with concomitant increase in glomerular filtration rate and renal clearance.


Increased plasma volume by 45%--50% while red cell mass increases only by 20%--30%, leading to dilutional anemia.
Young children with cryptosporidial diarrhea might infect adults during diapering and cleaning after defecation. Among persons with profuse diarrheal illness, a single stool specimen is usually adequate for diagnosis.
However, IRIS has occurred weeks after ART was started and in sequestered sites such as bone. The tidal volume increase of 30%--40% should be considered if ventilatory assistance is required. Methylprednisolone at 75% of the respective prednisone dose can be used if parenteral administration is necessary. Certain clinicians prefer IV pentamidine because of convincing data regarding its high degree of efficacy.


Failure attributed to lack of drug efficacy occurs in approximately 10% of those with mild-to-moderate disease.
The absence of IgG antibody makes a diagnosis of toxoplasmosis unlikely but not impossible. Person-to-person transmission is common, especially among sexually active men who have sex with men (MSM). Nationally distributed brands of bottled or canned carbonated soft drinks are safe to drink.



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