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Signs herpes outbreak is coming

They believe the herpes simplex virus is a significant factor in developing the debilitating disease and could be treated by antiviral agents such as acyclovir, which is already used to treat cold sores and other diseases caused by the herpes virus. Alzheimer's disease (AD) is characterised by progressive memory loss and severe cognitive impairment. Professor Ruth Itzhaki and her team at the University's Faculty of Life Sciences have investigated the role of herpes simplex virus type 1 (HSV1) in AD, publishing their very recent, highly significant findings in the Journal of Pathology. Most people are infected with this virus, which then remains life-long in the peripheral nervous system, and in 20-40% of those infected it causes cold sores. The team discovered that the HSV1 DNA is located very specifically in amyloid plaques: 90% of plaques in Alzheimer's disease sufferers' brains contain HSV1 DNA, and most of the viral DNA is located within amyloid plaques.
The team had discovered much earlier that the virus is present in brains of many elderly people and that in those people with a specific genetic factor, there is a high risk of developing Alzheimer's disease.
The team's data strongly suggest that HSV1 has a major role in Alzheimer's disease and point to the usage of antiviral agents for treating the disease, and in fact in preliminary experiments they have shown that acyclovir reduces the amyloid deposition and reduces also certain other feature of the disease which they have found are caused by HSV1 infection. Professor Itzhaki explains: "We suggest that HSV1 enters the brain in the elderly as their immune systems decline and then establishes a dormant infection from which it is repeatedly activated by events such as stress, immunosuppression, and various infections. The team now hopes to obtain funding in order to take their work further, enabling them to investigate in detail the effect of antiviral agents on the Alzheimer's disease-associated changes that occur during HSV1 infection, as well as the nature of the processes and the role of the genetic factor. Approximately two-thirds of all people under age 50 across the globe are infected with herpes simplex virus type 1 (HSV-1), the virus most commonly associated with cold sores, according to a World Health Organization (WHO) report released today in the journal PLOS One.
The burden of infection varies in different parts of the world and between men and women, according to the report.
HSV-1 is the same virus most commonly responsible for causing skin lesions, or “cold sores,” around the mouth, a disease than can be transmitted via skin-to-skin contact, such as kissing.
The research suggests that HSV-1 may be increasingly responsible for genital herpes as well, and it’s also been known to cause infections leading to blindness and, albeit rarely, encephalitis. In 2012, the WHO released a report on HSV-2 estimating that its global prevalence in people between the ages of 15 and 49 is around 11.3% — low in comparison to the HSV-1 estimates released in the new paper.
Since HSV-2 most commonly affects the genitals, it typically isn’t transmitted until people become sexually active.
However, in recent years research has increasingly shown that both HSV types can be responsible for either oral or genital infections, and either type may be transmitted via oral sex. It’s thought that genital HSV-1 infections are becoming particularly prevalent in developed nations.
So if fewer people are infected with the virus as children, they’re susceptible to genital infection as they become sexually active later in life, the WHO paper says. In other parts of the world, such as in Africa and Southeast Asia, the authors note that oral transmission in childhood is still high and has a tendency to protect people from genital infection later on. In addition to better tracking of a sexually-transmitted infection, such data collection can help scientists gain a better understanding of the ways the virus could influence other serious health conditions, Wald says. It’s unclear whether infection with HSV-1 has a similar effect as HSV-2 in raising the risk of HIV, according to Wald.
And HSV-1 is a leading cause of a condition known as HSV keratitis, which is an infection of the cornea that can lead to blindness.
Both types of HSV can also cause encephalitis, which is rare but can lead to severe brain damage or death. Both types of HSV are usually responsible for skin lesions only, which can be painful but are not typically seen as a serious health risk. This behavior is part of what makes the virus so difficult to track, as many people are unaware that they are infected. In the absence of symptoms, many medical providers also typically do not test for either type of the virus during routine sexually transmitted diseases (STD) screenings for a variety of reasons, some of them practical and others ethical. The Centers for Disease Control and Prevention (CDC) does not recommend testing for people who do not present with symptoms, stating, “STD screening tests are usually done for infections that can have serious outcomes if they are left untreated. That said, as HSV infection can be the cause of serious complications in some cases, it’s worth tracking on both a regional and global scale, Wald says. Cullen said it is perplexing that there's not more of an effort to cure both types of the Herpes virus.


While there are medications that can help prevent outbreaks, there is currently neither a cure nor a vaccine for either HSV-1 or HSV-2. In the new paper, the WHO concludes that continued global monitoring of the virus might help make a difference on that front.
Chelsea Harvey is a freelance journalist specializing in science, health and environmental reporting. It is freezing cold outside, you’re stressed out about finals, and now your good old friend, Herpie (your favorite cold sore), is back.   You and Herpie have been friends for a while now. That’s like asking why there isn’t a cure for the common cold (also caused by a virus, though not a herpes virus). Now to the fun stuff: products that may help quickly get rid of or prevent a cold sore that you can find at your local pharmacy and don’t need a prescription to get. How it works: Lysine is an amino acid your body absorbs when you eat eggs, red meat, cheeses, or fish (among many other sources). Does it work?: It’s not FDA approved for treating cold sores but there’s a lot of buzz and research into it. How to use it: There are creams like Lysine+™ that contain lysine as one of the main ingredients that you apply in the same way you apply Abreva at the first sign of a cold sore. Note: A lot of other natural products like tea tree oil, eucalyptus oil, and lemon balm are also being investigated as possible treatments for cold sores.
Cost: Greatly varies but like with any natural remedy make sure its good quality and from a source you trust.
You may have noticed that all these products ask you to start using them at the first sign of a cold sore.
The products below are frequently advertised as treatments for cold sores but they don’t contain any ingredients that make them particularly active against the herpes virus.
Again, this is a brief review of products that are available.  The world of cold sole- combating “medications” is filled with a ridiculous number of products but the cure has yet to be uncovered. Singh BB, Udani J, Vinjamury SP, Der-Martirosian C, Gandhi S, Khorsan R, Nanjegowda D, Singh V. Helpful advice for diagnosing and living (and loving) with different types of Herpes virus. After a few days, the herpes sore will release their liquids and thousands of little viruses. The sooner you take some action, the sooner you'll be able to calm your mind about whether you have herpes or not.1.
Watch me get a real herpes test with STDCheck (and how you can too!) Jul 21, 15 05:19 PMWatch me get a herpes test to see how easy it is. There Is Hope Mar 09, 15 09:31 PMI was devastated, this thing just kept getting crazier. There and Back Again from Singer to Statistic Mar 09, 15 08:46 PMSo I was involved in an operatic production at my Alma mater and became intimate with a student at said university.
7, 2008) a€” The virus behind cold sores is a major cause of the insoluble protein plaques found in the brains of Alzheimer's disease sufferers, University of Manchester researchers have revealed. Another future possibility is vaccination against the virus to prevent the development of the disease in the first place. It affects over 20 million people world-wide, and the numbers will rise with increasing longevity.
The team had previously shown that HSV1 infection of nerve-type cells induces deposition of the main component, beta amyloid, of amyloid plaques. They very much hope also that clinical trials will be set up to test the effect of antiviral agents on Alzheimer's disease patients. Above this age, the burden of infection would probably “trend toward 100%” in many places, says Bryan Cullen, director of the Duke University Center for Virology, although the WHO study doesn’t include these statistics. But while cold sores are a mostly cosmetic issue, there’s good reason to collect data on the virus, argue some experts. The other, HSV-2, has historically been associated with genital herpes and is almost exclusively sexually transmitted.


HSV-1, on the other hand, has historically been commonly transmitted in early childhood, for instance if an infected adult kisses an uninfected child.
The new paper notes that, worldwide, about half a billion people between the ages of 15 and 49 have a genital herpes infection caused by either HSV-1 or HSV-2. In fact, it’s the “biggest cause of infectious blindness in the United States,” says Cullen.
And infection of either HSV type in newborns can sometimes cause severe reactions, including high fever, seizures or even death. And while the lesions may recur repeatedly in some infected people, others become asymptomatic after the first outbreak — or they may never have an outbreak at all.
And while it’s possible to perform a blood test that will show whether the virus is present, “those kinds of studies are expensive and take up a lot of resources,” Wald says. Powered by its own proprietary technology, Mashable is the go-to source for tech, digital culture and entertainment content for its dedicated and influential audience around the globe.
These changes help prevent the cold sore virus from getting into healthy cells so the viral particles can’t spread to new cells. If you’ve ever had a cold sore you can probably tell your going to get one soon).  If you wait until the blister is fully formed, Abreva will still help but it won’t be as effective as it is if you use it right away. One trial found that 40% people treated with lysine at the first sign of outbreak were rid of their cold sore by day 3.  Pretty awesome if you ask us.
There are also pill forms of lysine that you can find in the vitamin section of some pharmacies. Lysine tabs can range in price depending on the brand (usually around $10) but definitely go for a well-known brand that uses high-quality sources of lysine. Virucidal effect of peppermint oil on the enveloped viruses herpes simplex virus type 1 and type 2 in vitro. Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes.
That's a good question.Often herpes sores get mistaken for other things like bug bites, ingrown hairs, or even pimples. Then usually triggered by stress, it goes up the ganglia of the nerves to the skin around the mouth or genital area.It hangs out under the skin for a few days. It will make the skin red and irritated.Then the herpes virus will create small liquid pus-filled blisters at the surface of the skin.
Together, these findings strongly implicate HSV1 as a major factor in the formation of amyloid deposits and plaques, abnormalities thought by many in the field to be major contributors to Alzheimer's disease. In the Eastern Mediterranean, 75% of both men and women are infected and 87% of both men and women are infected in Africa. Infection with HSV-2 can have more serious consequences, too, since it has been shown to increase a person’s risk of becoming infected with HIV. Once infected with the virus in one part of the body, the immune system generally protects against infection in another area. How does it do this?  We’re not sure just yet…but if the cold sore goes away, does it matter?
This combination of red skin and blisters is known as a herpes sore.Usually there will be many little blisters clustered together. A pimple looks like herpes because it has red skin with a white blister on top.The difference however are many. Most cases of genital herpes are caused by herpes simplex virus type 2 (HSV2) while most cold sores are cause by HSV1 but both viruses can (although much less common) cause sores in the opposite region if the active virus comes in contact with that region (use your imagination here). Which means no kissing, or sex, or touching the herpes sores.Then the blisters or herpes sores will turn into scabs.
So as you shed skin in the infected area, the herpes virus can be spread through skin to skin contact.



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Comments
  1. Ramin62 17.08.2014 at 19:16:26
    Child from a herpes infected mom.
  2. dfdf 17.08.2014 at 15:30:11
    Oral formulation of tenofovir, which is marketed.