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HealthDay News — Pericoital application of tenofovir gel may substantially cut women's risk of contracting herpes simplex virus type 2, according to a study published in the the New England Journal of Medicine. The current trial was not primarily designed to test tenofovir gel against herpes simplex virus type 2 (HSV-2); its main aim was to curb the risk of HIV transmission. Earlier results from the trial had suggested the gel version can reduce women's risk of contracting HIV. The current study looked at a subgroup of women who'd taken part in the larger trial testing tenofovir gel against HIV. The investigators found that over 18 months, women who used the drug-containing gel were 51% less likely to contract HSV-2, compared to the placebo group. The gel is still experimental, stressed study leader Salim Abdool Karim, MB, ChB, PhD, director of the Center for the AIDS Program of Research in Durban, South Africa.

The oral formulation of tenofovir, which is marketed as Viread, is already used to treat HIV. However, follow-up research yielded disappointing results — largely because many women were not able to use the gel consistently. The group included 422 who were free of HSV-2 when they were randomly assigned to use either the drug or an inactive placebo gel; they were told to apply it vaginally before and after having sex. Further research will probably be necessary for drug regulators in various countries to consider approving the medication, Karim told HealthDay. Actually the success that enveloped viruses have against animals is due, in large part, to the fact that almost all enveloped virus proteins are glycoproteins (Proteins with sugar chains attached).
Also the budding of enveloped viruses is not often a gentle process in which the cell remains intact.

Enveloped viruses often (not always) cause massive cell lysis just as non enveloped viruses do. All pathogens will be inactivated by some temperature and all will be inactivated by some concentration of acid. But yes, they are generally more resistant to the environment outside the body than enveloped viruses.4) Non-enveloped viruses induce antibodies and enveloped viruses induce both antibodies and cell-mediated immune responses. For example, if you eat vegetables, your feces will contain massive amounts of non-enveloped plant viruses that passed through you more or less intact.

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