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Signs herpes outbreak is coming

A new drug, called pritelivir, may offer a new treatment option for patients with genital herpes, a new industry-sponsored – study led by University of Washington researchers has found. Currently, there are treatments that shorten outbreaks, prevent recurrences and reduce transmission to sex partners, and but there is no cure. These treatments include the prescription drugs Acyclovir (Zovirax), Valacyclovir (Valtrex) and Famciclovir (Famvir), which all inhibit viral replication by inhibiting a viral enzyme called HSV DNA polymerase. The new drug, pritelivir, is the first in a new class of drugs that inhibit HSV by targeting a different part of the virus’s replication machinery, the helicase-primase enzyme complex.
In the new study, 156 patients with genital HSV-2 infection were randomized to receive either placebo or four different dosage regimens of the new drug for 28 days. All the patients kept a diary recording any signs and symptoms of the infection and swabbed their genital areas daily.
Side effects of the treatment were few and mild, and there were no signs of drug resistance developing. Recent mentions of the University of Washington in the newsDo Trump’s racist appeals have a silver lining?
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The researchers also reported that the drug group had genital lesions only on 1.2 percent of the days.
Although the researchers did not find any side effects of pritelivir, the development of the drug was previously halted by the United States' Food and Drug Administration (FDA) after the drug caused toxic effects in monkeys.
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As a result, most people who have been infected with HSV-2 are unaware they are infected, though they can still transmit the virus to others. Genital herpes is a sexually transmitted infection (STI) that is caused by either the herpes simplex virus type 1 (HSV-1) or type 2 (HSV-2). Some of the participants were randomly given 75 milligrams of the experimental drug called pritelivir.
Richard Whitley, a professor of pediatric infectious diseases at the University of Alabama at Birmingham commented according to FOX News. The infection, which is usually transmitted through sexual contact, can cause pain and sores in the genital area, anal region and lips.
What’s more, substantially less virus was present during breakthrough shedding in persons receiving pritelivir, another indication of the drug’s efficacy. Food and Drug investigates the findings of a toxicology study in which monkeys receiving high doses of pritelivir, doses 70 to 900 times as high as a 75 mg dose in humans, developed blood and skin abnormalities. People who received that drug had viral shedding on 2.1 percent of time spent in the study. Even thought this study's findings are promising, the researchers cautioned that all they identified was a "proof of concept." They reiterated that pritelivir has the potential to treat genital herpes.
However, more research would need to be done before the drug can actually be prescribed for the STI. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.



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