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Signs herpes outbreak is coming

Genital herpes may have met its match, a new industry-sponsored study led by University of Washington researchers suggests.
Called pritelivir, the drug is a product of the pharmaceutical company AiCuris, which backed the new study published in the New England Journal of Medicine. According to the researchers, an estimated one in six Americans between ages 14-49 have herpes, with the most recurrent type being that caused by herpes simplex virus 2, or HSV-2.
The new drug is the first in a new class that inhibits HSV by targeting the virus's so-called helicase-primase enzyme complex. In the study, 156 patients with a genital HSV-2 infection received either a placebo or four dosage regimens of pritelivir.
Of the four different regimens, the one in which participants were given an initial dose of 300 milligrams followed by 75 mg each day resulted in the fewest number of days with genital lesion. However, while side effects were reportedly mild, additional clinical studies are on hold while health officials investigate a toxicology study in which monkeys receiving doses 70-900 times higher than a 75 mg dose in humans developed blood and skin abnormalities.


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Click on a title to look inside that book (if available):Obstetrics by Ten Teachers, 19th Edition (2011) by Philip N. In most cases, symptoms are either mild or absent, meaning infected individuals may be unaware of their status and their potential to spread the virus.
Other treatments - including Famvir, Valtrex and Zovirax - work by hampering viral replication by inhibiting an enzyme known as HSV DNA polymerase.
All patients were then asked to keep a diary in which they recorded any signs or symptoms and swab their genital areas each day.
The dose also resulted in an 87 percent reduction in days of viral shedding when compared to those taking the placebo. When symptoms do flare up, however, they can result in pain and sores in the genitals and lips.


However, while treatments currently in existence are able to shorten outbreaks, reduce transmission and prevent recurrences, a cure has yet to be found. The swabs then underwent testing in order to determine whether the virus was shedding, and if so, how much. In addition, there was far less virus present during breakthrough shedding in those taking pritelivir, the researchers found. But, Sarah Palin to the GOP, this is what I've got to say: She is very much like herpes - she's not going away.



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Comments
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