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Of the 26% of patients who responded to the new cancer treatment, known as T-Vec, one in 10 saw their tumours vanish without trace. A genetically-modified cold sore virus could be be made available as a game-changing new treatment for skin cancer within a year, scientists claim.
Extraordinary results from a Phase III trial involving patients with aggressive, inoperable disease have shown that the therapy can eradicate tumours and halt their growth.
The unique treatment combines a direct targeted attack on cancer cells with an immunotherapy approach that primes the body’s own defences to combat the disease. A total of 436 patients with aggressive, inoperable malignant melanoma were recruited, of which 295 received injections of T-Vec.
Of the 26% of patients who responded to the herpes virus treatment, known as T-Vec, one in 10 saw their tumours vanish without trace. T-Vec is one of a new generation of virus-based drugs in development and the first to show real potential in a major Phase III trial, the last step before a new medicine is licensed and made available to patients.
It contains the same herpes simplex type-1 virus that causes cold sores, genetically engineered to make it harmless to patients but lethal to cancer. The virus is unable to multiply in healthy skin cells but finds fertile ground for growth in tumour cells. At the same time, the GM virus produces a molecule called GM-CSF which acts as a potent immune system stimulator. This has the effect of priming the immune system to recognise and attack tumour proteins left in the debris of the obliterated cancer cells. Overall, 26% of patients who received T-Vec and 6% of those in the control group responded to treatment. Patients with earlier stage disease who were given T-Vec as their first treatment also experienced a significant survival benefit, living an average of 41 months. EU drug regulator the European Medicines Agency is looking at the trial results and is expected to deliver its initial verdict on T-Vec later this year. A new method to target melanoma that was just approved by the FDA could be an important first step in transforming the way we treat many cancers.
The treatment is called Imlygic, and it uses a virus to kill skin cancer cells, while leaving healthy cells alone.
He said Imlygic's most promising applications may be in combining it with other treatments, so patients could receive it before or after surgery, or with chemotherapy or other drugs.


Viruses are extremely good at infecting human cells; the Ebola virus, like many others, can invade the body and then lay dormant for months.
To make Imlygic, researchers at a company called BioVex, which Amgen acquired in 2011, modified a herpes virus so that it wouldn't cause cold sores, but would instead make and deliver GM-CSF, a type of protein that notifies the body's immune system that it should fight cancerous cells. Many vaccines work in a similar way: The hepatitis A shot, for example, is a dead form of the hepatitis A virus.
BioVexHow Imlygic works.Imlygic is injected directly into the tumor, where the modified herpes viruses infect cancer cells.
The treatment causes skin cancer cells to burst, and the immune system activates to take care of the rest. The side effects were mostly minimal though, with the most common being flu-like symptoms and pain at the injection site. Patients who received Imlygic lived a few more months than patients who just received GM-CSF, but this result wasn't statistically significant. Almost 92% of people with skin cancer are still alive five years after their diagnosis, but this figure drops to only 17% if the cancer has metastasized and spread to other parts of the body, according to the National Cancer Institute.
Imlygic is the first cancer-killing, so-called "oncolytic virus" that the FDA has approved for treatment, and it could pave the way for many more to come. Oral Medicine is a specialty within dentistry that rests at the interface of dentistry and medicine.  The oral health and care of patients with chronic, recurrent, and medically related disorders of the oral and maxillofacial region and the diagnosis and management of these conditions is Oral Medicine.
Oral Medicine assesses, diagnoses, and manages symptoms of the mouth and oral and maxillofacial structures (mouth, lips, gums, jaws, tongue, soft and hard palate, and face) that often do not have any relationship to the teeth.  These symptoms and conditions are usually associated with a high degree of psychological and physical morbidity on a persons quality of life. In other cases, the oral manifestations or ‘signs and symptoms’ may be the first indication of an underlying local problem related to the mouth such as oral cancer, oral thrush, periodontal disease, or dental disease, or they may represent widespread a more widespread general condition, for example diabetes, cancer, or immune suppression.  Therefore, the actual scope of Oral Medicine is very broad and often requires close liason and co-operation with other general and specialist medical facilities.
Typically therefore, Oral Medicine practitioners work closely with a patients medical GP, medical specialist (Oncologist, Rheumatologist, Endocrinologist, Cardiologist, Gastorenterologist, Respiratory and General Physician), General Dentist, and Oromaxillofacial Surgeon. However, Oral Medicine also forms a significant part of post surgical management in patients with chronic or complex diseases and illnesses.
About UsHere at the Hobart Orofacial Pain and Special Needs Clinic, our philosophy is simple. Folliculitis refers to an infection in a hair follicle, a skin opening containing the hair root, in the form of itchy and tender pustules and papules.
Eventually the virus proliferates to such an extent that it literally explodes out of the cancer cells, destroying them.


This compared with a survival time of around 21.5 months for earlier-stage patients given GM-CSF. Robert Andtbacka, an oncologist at the University of Utah who's been involved in Imlygic's development since before it had a brand name, told Tech Insider that he and his team are already looking at adapting the method to treat head, neck, breast, and liver cancers in clinical trials. So scientists are harnessing viruses to do what they're best at a€” but make them help instead of harm once they enter the body. Once it enters the body, the immune system identifies it as an intruder and makes antibodies against it so if a live virus comes along, it will be protected. Injections are administered every few weeks until the cancer is gone, which in the final Phase III clinical trial took an average of about four months a€” for the patients that responded to the treatment. So the effect is modest: For most patients who received Imlygic, their tumors did not shrink. In the clinical trial, one-third of patients who received Imlygic were alive after five years, and all of them had melanoma that had metastasized to some degree. In 2015 alone, the National Cancer Institute estimates that nearly 74,000 people will be diagnosed with melanoma, and about 9,900 will die from the disease.
The key difference from Oromaxillofacial surgery is that the emphasis on treating conditions are primarily managed without the need for surgery. Yet researchers are excited about the new approach: It's the first virus-based cancer treatment that's gotten a stamp of approval from the FDA. Andtbacka said Imlygic is a powerful new tool for oncologists to target melanoma, especially in its late stages.
Andtbacka said he suspects it's because the modified herpes virus can only replicate inside cancer cells.
Folliculitis on vagina would appear like a small pimple filled with pus at the base of the vagina (though not to be necessarily regarded as a sexually transmitted disease), and is usually accompanied with symptoms like itchiness, sores, pain and irregular discharge. There could be scientific causes attached to folliculitis or bumps on the vagina in the form of sebaceous cysts. Folliculitis on vagina can be cured through antibiotics or injection of the appropriate drug.




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