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Signs herpes outbreak is coming

The study is being published September 14 in Science X-Press, an advanced, online edition of the journal Science. In the study, the scientists suggest that herpes simplex encephalitis may reflect a single gene immunodeficiency that confers susceptibility to herpes simplex virus, an idea that contrasts with the prevailing scientific theory of how genes work to make people vulnerable to infections. In the study, researchers focused on blood cells from two French children with a deficiency for UNC-93B, an endoplasmic reticulum protein involved in the recognition of pathogens. This deficiency resulted in high rates of herpes simplex virus-1 proliferation and cell death. Herpes simplex virus-1 is a common virus that infects about 80 percent of young adults worldwide.
Nonetheless, herpes simplex encephalitis, which was first described in 1941, is the most common type of sporadic viral encephalitis in developed countries, accounting for about 10 to 20 percent of all viral encephalitis cases, as per the University of Maryland Medical Center. Did you know?The study is being published September 14 in Science X-Press, an advanced, online edition of the journal Science. Feline Herpes Virus (FHV) is a common pathogen (infectious agent) that causes an upper respiratory disease and ophthalmic (eye) disease in cats. The virus can also be spread in an aerosol form, meaning a cat gets infected after exposure to the sneeze of an infected cat. The feline herpesvirus most commonly infects kittens and causes sneezing, ocular and nasal discharge, and a reluctance to eat and play.
Whenever your pet is showing signs of a health issue your first step is to contact your primary care veterinarian.
Feline herpes virus is most commonly an upper respiratory and ocular disease causing virus and is prevalent in environments with multiple cats or when new cats are introduced. A FHV infection may be suspected anytime a cat has an eye infection that does not respond to antibiotics, which have no effect on viruses.


Assuming these findings extend to neurons, they provide a plausible mechanism for herpes simplex encephalitis. Herpes simplex encephalitis, a viral infection of the brain that affects otherwise healthy patients, affects an extremely small percentage of those infected with herpes simplex virus-1: the number of annual cases is two per million people, as per the University of Maryland Medical Center. Before the advent of anti-viral drugs vidarabine in 1973 and acyclovir in 1981, mortality rates reached up to 70 percent.
Exposure to this virus is common and known to be greater in breeding colonies, catteries, shelters, and multi-cat households. Drying and sunlight can kill the virus, but it can live for many hours in a moist, cool environment.
With good nursing care, the vast majority of kittens return to normal within several weeks. Adult cats with an eye infection due to FHV are more likely to be suffering from viral re-activation than from a primary (newly acquired) viral infection. If it is indicated that your pet may suffer from Feline Herpes Virus or another serious condition, a veterinary specialist is available at an ExpertVet certified hospital. The virus replicates in the upper respiratory tract and conjunctival tissue of the eye during primary infection.
One of the more common diagnostic tests to confirm a FHV infection involves applying topical anesthestic and taking cell (cytology) scrapings from the eye.
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While the introduction of anti-viral therapy has been a boon to patients, brain damage still poses a substantial risk.
It is believed that many kittens are exposed to this virus following birth as the virus can be found in the birth canal of the mother.


Symptoms accompanying the disease include sneezing, nasal discharge and discharge from the eyes. The slide is submitted to a laboratory for a specific test procedure known as a Polymerase Chain Reaction (PCR) test. Approximately 80% of FHV infected cats become latent carriers with a 45% chance of viral re-activation. There can be other secondary ocular problems associated with FHV which will be mentioned later in this article. However, when the eyes are affected, there are numerous ways the disease can manifest that vary due to the pet’s age, immune system, and viral load. A different diagnostic test, known as the Indirect Fluorescent Antibody Test (IFA), can also be performed.
While the IFA test is not as precise as the PCR test, performing both tests simultaneously indicates the presence of herpes better than using either test alone.
FHV may remain dormant or “inactive” in the cranial nerves (often the trigeminal nerve ganglion) which serve the eyes. Another test that can be used is virus isolation (VI), which actually grows the virus in tissue cultures. There is evidence that many ocular diseases are associated with herpes virus and recurrence can be frequent.



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Comments
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