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The HAPPY study is a large prospective longitudinal cohort study in which pregnant women (Na€‰a‰?a€‰2,500) are followed during the entire pregnancy and the whole first year postpartum. During pregnancy, participants receive questionnaires at 12, 22 and 32 weeks of gestation. The key strength of this large prospective cohort study is the holistic (multifactorial) approach on perinatal well-being combined with a longitudinal design with measurements during all trimesters of pregnancy and the whole first year postpartum, taking into account two physiological possible markers of complaints and symptoms throughout gestation: thyroid function and HCG. BackgroundAntenatal physical and mental well-beingPregnancy is a period during which a woman faces a substantial number of physiological changes of the body, commonly together with psychological changes. Multifactorial model with hypothesized associations between physiological and psychological factors during pregnancy. Also, the occurrence of maternal distress (anxiety and depression) is assessed during different trimesters. With regard to the postpartum period, the primary aim is to investigate the effect of chronic depression during pregnancy on postpartum recovery. Women who receive epidural analgesia during labour are at risk for poor breastfeeding figures during the first postpartum week. Apart from a previous obstetric history, the questionnaires include demographic features, assessment of distress symptoms and somatic symptoms which are frequently mentioned during physiological gestation. To measure pregnancy-related emotional distress, the 16-item Tilburg Pregnancy Distress Scale (TPDS) [69] with subscales a€?negative affecta€™ and a€?partner involvementa€™ is assessed at each trimester of pregnancy. DiscussionWithin the HAPPY study, we aim to evaluate the relationships between several physiological and psychological factors and antenatal and postpartum maternal and infant well-being. AcknowledgementsWe are indebted to all midwives of the 17 participating midwifery practices in South-East Brabant (Eindhoven area) for their contribution in recruiting participants. Sarah Jane Sandy, founder of Janey Appleseed Nutrition, is a Certified Nutrition Therapist and Registered Yoga Teacher with a passion for educating others about the healing qualities of food.
Sarah specializes in teaching couples how to increase fertility, the importance of preconception care, and the essentials of a healthy pregnancy and postpartum nutrition. It is a science-based holistic approach to healing rooted in the conviction that food, as Nature intended, is a form of medicine that can heal, protect, nurture and support good health.
Plus, receive updates from me chock full of goodies, tips and tricks, and other things I know will help you succeed. Can you explain how a psychological or emotional issue can actually affect the physical body? Can you provide an example of how a holistic approach is applied when treating an individual for a mental illness, like for example, depression? You also specialise in weight loss, how are your weight loss programs different to other weight loss programs?
Michelle has over 22 years experience working with human behaviour through psychology, hypnotherapy, counselling, coaching, training, personal development and human resource management. Michelle offers a unique holistic approach to health and well-being; meaning that she’ll address not only a client’s symptoms, but all potential contributing factors which may be affecting their health. Michelle specialises in depression, stress management, anxiety and phobias, low self-worth, weight loss, and insomia.
Shannon is deeply committed to working with couples, helping facilitate healthy pregnancies and healthy babies. Shannon works in conjunction with Midwives, Doctors, our in house practitioners, and practitioners in the birthing community  to provide a well rounded approach to wellness.  Her sessions help to foster the best possible outcome for you and your baby. The study collects a substantial amount of psychological and physiological data investigating all kinds of determinants that might interfere with general well-being during pregnancy and postpartum, with special attention to the effect of maternal mood, pregnancy-related somatic symptoms (including nausea and vomiting (NVP) and carpal tunnel syndrome (CTS) symptoms), thyroid function, and human chorionic gonadotropin (HCG) on pregnancy outcome of mother and foetus. Apart from a previous obstetric history, demographic features, distress symptoms, and pregnancy-related somatic symptoms are assessed.
The HAPPY study is among the first to investigate within one design physiological and psychological aspects of NVP and CTS symptoms during pregnancy. Secondly, the changes in thyroid function are measured over time during pregnancy and we will investigate a possible independent effect of thyroid dysfunction on foetal development as assessed by a standardized ultrasound protocol at 18a€“22 weeks gestation.
The HAPPY study is conducted in South-East Brabant (southern part of The Netherlands), in the Eindhoven area. The key strength of this large prospective cohort study is the holistic (multifactorial) approach on perinatal well-being combined with a longitudinal design with measurements during all trimesters of pregnancy and the whole first year postpartum. Furthermore, we would like to thank Carola Boerekamp-Lavrijssen, for her contribution in organizing the planning and logistics of this study. Homeopathic individualized medicines versus fluoxetine for moderate to severe depression: double-blind, randomized non-inferiority trial.
Increased vitality, glowing skin, balanced blood sugar, ideal weight, a well functioning brain, freedom from nagging symptoms, and a vibrantly healthy life are absolutely within your reach.
Coupled with intentional, functional exercise, holistic nutrition represents an awe-inspiring therapy. Michelle is a qualified specialist working with human behaviour; she is a registered Psychologist, an internationally accredited Master Practitioner and Trainer of Neuro Linguistic Programming (NLP), Hypnotherapy and Life Coaching, and a qualified practitioner in Emotional Freedom Technique (EFT). As a solutions-focused practitioner, her goal is to create long-lasting changes by constructing practical solutions with a client; rather than dwelling on their problems, focusing instead on what they want to achieve moving forward. We want women to know that they don’t have to suffer without support!  Acupuncture is a safe, gentle and effective way to address common pregnancy related complaints. She believes in our bodies miraculous and innate power to create, maintain, and give birth to new life. Dorrien, LCSW-R is a NYS Licensed Clinical Social Worker who has over 13 years of experience working with children, adolescents, families, adults and couples.
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Furthermore, obstetrical data of the obstetric record form and ultrasound data are collected during pregnancy. Finally, the concept of anhedonia and depressed mood as two distinct aspects of depression and its possible relation on obstetric outcome, breastfeeding, and postpartum well-being will be studied. Tertiary outcome is the relation between psychological determinants and initiating and continuation of breastfeeding.
South-East Brabant is defined as semi-rural and about 7,000 babies were born in this area in 2012. Moreover, cord blood is collected after cutting of the umbilical cord, to be used for neonatal thyroid function assessment, which accurately represents foetal thyroid function. Data of ultrasounds performed at other time points during gestation are also collected.Blood analysis of thyroid function and HCGTSH, FT4, TPO-Ab, and HCG are measured in Li-heparin plasma using electrochemoluminescence assays (CobasA® e 601, Roche Diagnostics, Mannheim Germany). The EDS is a reliable instrument for screening depression in each of the three trimesters of pregnancy. The HAPPY study is unique in several aspects.First, within one design, a psycho-physiological model to explain NVP will be tested with special attention to HCG and thyroid function. Ubiratan Cardinalli Adler, UNIFESP (Federal University of SA?o Paulo, Brazil), Av Rouxinol, 1041 cj. Taking the steps to feel, look, and perform your very best is the most important investment you’ll ever make. The right type of quality food, when digested and absorbed properly, benefits the unique individual biochemistry of our bodies, our brain function and our emotional well-being. Michelle also has many years’ experience working in corporate human resource management and consultancy.
Treatment approaches include CBT, Play Therapy, Psychodynamic, Family Systems, 12 Steps, Holistic & Spiritual modalities to deal with issues such as: ADHD, ODD, PTSD, Anxiety, Depression, Divorce, Parenting, Postpartum Depression, Anger Management, Addiction, Abuse, Family Conflict & Grief.
At 12 and 30 weeks, thyroid function is assessed by blood analysis of thyroid stimulating hormone (TSH), free thyroxine (FT4) and thyroid peroxidase antibodies (TPO-Ab), as well as HCG. In its extreme form, NVP or a€?morning sicknessa€™ can manifest itself as hyperemesis gravidarum (HG), a potentially life threatening but rare condition (0.5-2%) which is characterised by nausea, vomiting, severe dehydration and weight loss resulting in hospitalisation [2]. Seventeen community midwife practices (consisting of 55 midwives) consented to participate in the recruitment of participants.
As holistic nutritionists, we are passionate about using food as therapy; to heal, to transform, to change, and to nourish. Our bodies are brilliant and are amazingly capable of restoring balance when given the proper raw materials. If our mind is clear and self-reflective, it will help us choose ideal food, activity, and all other life patterns.
Our Smithtown and Riverhead Professional Buildings offer office space and business services for your business, professional health, therapy or medical practice. Also, depression is assessed with special focus on the two key symptoms: depressed mood and anhedonia.
The EDS total score ranges from 0 to 30, with higher scores indicating more depressive symptoms. Secondly, the prevalence of CTS is assessed using a standardized and validated questionnaire and a possible relation between CTS symptoms and thyroid function during pregnancy will be tested, which has never been reported before. Collaborators are considered as co-author as they have significantly contributed to development of this study, preparation of data acquisition, and writing or revising this manuscript. There is a need for large-scale longitudinal data on treatment utilization and outcomes, stress, emotion, and pain. We believe that whole, real, pastured, wild caught, traditional, nutrient-dense, properly prepared foods are the keys to unlocking one’s most vibrant self. After childbirth, cord blood, neonatal heel screening results and all obstetrical data with regard to start of labour, mode of delivery and complications are collected.
However, studies that investigated in one design both HCG and thyroid function, as well as psychological background features of NVP, have not been reported.Carpal tunnel syndrome (CTS) is common during gestation and occurs because of compression of the median nerve in the wrist in one or both hands, leading to a tingling sensation, numbness and sometimes pain. The care providers of the obstetric departments collect umbilical cord blood after delivery and provide the fully completed obstetric record forms for data analysis after written informed consent of the participants. Trimester-specific cut-off points were determined, lower than the commonly applied cut-off in the postpartum period. Third, suboptimal maternal thyroid function has repeatedly been associated with poor development of the foetal CNS. Location is not a problem — we work with clients in person in the Denver and Boulder, CO area, as well as with people around the world via phone, Skype, or other videoconferencing method.
Moreover, mothers receive questionnaires at one week, six weeks, four, eight, and twelve months postpartum, to investigate recovery after pregnancy and delivery, including postpartum mood changes, emotional distress, feeding and development of the newborn. Especially hormonal changes [4], and fluid retention [4, 5] have been suggested as contributing factors to development of CTS in pregnancy.
The Primary Care laboratory of Eindhoven (Diagnostiek voor U) is responsible for collection of the blood samples and the ultrasounds. A cut-off value of 11 in the first trimester and of 10 in the second and third trimesters gives the most adequate combination of sensitivity, specificity, and positive predictive value [72].
However, combining maternal thyroid function with the objective parameters of development of the CNS assessed by ultrasound at 20 weeks gestation has hardly been described.
Randomized long-term trial of camel milk as an adjunct to insulin therapy in type-1 diabetes.
CTS occurs most frequently during the third trimester of pregnancy and a majority of women have symptoms that are severe enough to affect hand function and sleep [6], resulting in impaired quality of life [7, 8]. The Laboratory of clinical chemistry and haematology of the MA?xima Medical Centre Veldhoven is responsible for analysis of TSH, FT4, TPO-Ab and HCG and storage of the blood samples.RecruitmentDutch-speaking Caucasian women (or third generation women of other ethnic groups) who have their first prenatal visit between January 2013 and September 2014 are eligible to participate in the study from the early beginning of their pregnancy. The EDS has repeatedly been shown to consist of three subscales: anhedonia, anxiety and depression, with anhedonia and depression assessing different concepts of depression [73]. Fourth, within the abundant literature on perinatal depression, there are very few papers looking at the concept of anhedonia and depressed mood, the two key symptoms of depression.
In addition, the speed and stresses of modern life encourage the consumption of cheap, fast, processed food, which in time can lead to many chronic health problems. Accurate data of prevalence rates are difficult to find in the literature and vary substantially (1-60%) [9a€“11]. Exclusion criteria in this study are: gemelli pregnancy (or higher order pregnancies), endocrine disorder, use of thyroid medication, severe psychiatric disease (schizophrenia, borderline, or bipolar disorder), HIV, drug or alcohol addiction problems, or any other disease resulting in treatment with drugs that are potentially adverse for the foetus and need careful follow-up during pregnancy. Fifth, because The Netherlands have relatively few women asking for epidural anaesthesia during labour (a risk factor for increased instrumental delivery), it is possible to look at psychological determinants predicting a request of analgesia. This is mainly explained by the fact that most women do not report the symptoms, physicians do not ask for them and a€“ possibly due to the conservative attitude towards treatment during pregnancy a€“ most women with (substantial) CTS symptoms do not receive electrodiagnostic examination (EDE) [12]. Eligible pregnant women (and their partner) receive written and oral information about the study at their first prenatal visit.
Therefore, within the HAPPY study, the EDS has been extended with several anhedonia items depicted from the Dutch validated version of the MASQ (Mood and Anxiety Symptoms Questionnaire, originally developed by Watson and Clark in 1991 [74, 75]).
Finally, the attitude towards initiating and continuation of breastfeeding are assessed, taking into account demographic and psychological characteristics that have repeatedly been assessed during gestation.Another strength of the study is the large sample size (2,500 participants) which will enable to look at possible relations between psychological and physiological determinants and obstetric complications but which are relatively rare (preterm birth, pre-eclampsia, intrauterine growth restriction). Patients are recruited from web sites for patient advocacy and health enhancement programs. However, the Boston Carpal Tunnel Questionnaire (BCTQ) [13] has shown to be a highly reliable and sensitive self-rating questionnaire for CTS [14, 15]. Recruitment takes place by the midwives of 17 primary care community midwife practices in the area of South-East Brabant, from January 2013 until September 2014.The Dutch obstetric care system is organised in primary care - represented by independent midwives providing care to women with low-risk pregnancies - and secondary care, represented by hospital midwives and gynaecologists who are responsible for high-risk pregnancies.
Therefore this long-term study was undertaken to assess the efficacy, safety and acceptability of camel milk as an adjunct to insulin therapy in type 1 diabetic patients.
Moreover, it is a user-friendly instrument which can easily be used during pregnancy to assess the occurrence of CTS. The 10-item EPDS has been validated among postpartum women in The Netherlands and revealed appropriate psychometric characteristics with a Cronbacha€™s alpha of 0.87 [70, 71]. During this period several cohorts have been formed showing an overall and stable recruitment rate of over 70% after inviting women through their midwife to participate into pregnancy research [69, 72, 86]. Methods: In this 2-year randomized clinical parallel design study, 24 patients with type 1 diabetes were enrolled and divided in 2 groups.
An underactive thyroid, called hypothyroidism (HT), has been long time reported to be associated with increased risk of CTS.
The total score ranges from 0 to 30, with higher scores indicating more depressive symptoms. Group I (n=12) received usual care (ie, diet, exercise, and insulin), and group II (n=12) received 500 mL camel milk in addition to diet, exercise, and insulin. In a systematic review [16], the pooled odds ratio of HT patients of CTS was 1.4 indicating a 40% higher prevalence rate of CTS in patients with HT compared to healthy controls.
The high-risk population consists of women with gemelli pregnancy or with chronic diseases such as diabetes, thyroid dysfunction, hypertension, or psychiatric disorders; all exclusion criteria for participation.
HT might produce alterations of fluid balance and peripheral tissue oedema resulting in nerve compression in the carpal tunnel. As 84% [31] of all pregnant women will have at least one prenatal visit in a primary care midwifery practice (usually a first antenatal control between six to ten weeks of gestation), recruitment takes place by the primary care community midwives. The GAD-7 consists of seven items with a four-point Likert scale (0a€‰=a€‰a€?not at alla€™ to 3a€‰=a€‰a€?nearly every daya€™). A possible relation between CTS symptoms and thyroid function during gestation has not been reported in the literature yet. The total score ranges from 0 to 21, with higher scores representing higher levels of anxiety symptoms [77]. Apart from these physiological changes, a considerable proportion of pregnant women experiences psychological distress, varying from pregnancy-related worries to general symptoms of anxiety and depression. During regular blood assessments (10a€“12 weeks and 26a€“30 weeks of gestation), an additional tube of blood is withdrawn for thyroid function and HCG analysis. Cut-off points of 5, 10, and 15 are associated with respectively mild, moderate, and severe levels of anxiety [78].To assess the severity of NVP (or a€?morning sicknessa€™) in the early phase of pregnancy, we use the first trimester Pregnancy-Unique Quantification of Emesis (PUQE) scale [2]. The occurrence of distress during pregnancy is subject to much debate: is there an increasing number of women suffering from depression and anxiety throughout gestation?
The assessment is based on three physical symptoms over the first trimester: nausea, vomiting, and retching. The literature is inconclusive, mostly because there are very few studies that repeatedly assessed anxiety and depression. Written informed consent includes participation in the study and inclusion of all obstetric data from the medical record form of the community midwife and obstetrician (including ultrasound data), a detailed delivery description and neonatal condition, and data of newborn screening (heel prick test).The HAPPY study is approved by the Ethical Board of Tilburg University (with special attention to the type of questionnaires that are used) and has been evaluated by the Medical Ethical Committee of the MA?xima Medical Centre Veldhoven.
The PUQE, which consists of three quantification items with five answer categories, appears to be a reliable instrument to determine severity of nausea and vomiting during pregnancy [2].
Most studies measured these symptoms only once during pregnancy, a few studies twice, but the systematic review of Bennett et al.
Because all additional blood samples were obtained during regular blood assessments as part of regular obstetric care, the board confirmed that no additional approval of a medical committee was needed.Sample size calculationThe total amount of pregnancies in the area of the 17 community midwife practices is about 5,000 per year.
With 10-15% non-Caucasian, 10-15% early abortion rate and 1.7% gemelli pregnancies, approximately 3,700 pregnant women will be eligible annually. Subsequently, the Boston Carpal Tunnel Questionnaire (BCTQ) is a disease-specific CTS questionnaire that consists of two subscales: the symptom severity scale (11 items) and the functional status scale (8 items).
Based on previous pregnancy-related research experiences of the last 20 years in this area, the response rate is expected to be high (70%) especially when no additional blood tests or interventions have to be performed. Previous studies have found that between 30% and 60% of pediatric neurology patients have used CAM at some point in their lives.
Furthermore, some researchers suggested symptoms of depression and anxiety to be stable throughout pregnancy [19], while others stated that maternal mood and well-being fluctuate across pregnancy [20]. The BCTQ is assessed at 32 weeks of gestation and retrospectively at one week postpartum to evaluate CTS symptoms during the last eight weeks of pregnancy. With regard to depression, there is growing awareness that the two key symptoms of depression (depressed mood and anhedonia) are two distinct entities with possibly different impact on health [21, 22]. During pregnancy, the rate of women moving outside the area is in general low which means that a number of 2,500 women are expected to finish the study protocol until delivery. Depressed mood is more and more regarded as a state, while anhedonia is regarded as a trait factor of depression.
After a pilot period of three months followed by a running-in period of three months, it is estimated that all midwife practices will collaborate within six months.
The confirmatory factor analysis will be done using AMOS (version 18, IBM, Chicago, Illinois, USA).First, we will test for normality and the computation of descriptive statistics.


Although this distinction has become increasingly apparent in psycho-cardiology [23, 24] (it is especially anhedonia that has been related to poor cardiovascular outcome rather than depressed mood [24]), this concept has hardly been investigated in perinatal research. Data will be presented as mean scoresa€‰A±a€‰SD for continuous data and as percentages for categorical data. As a consequence, conflicting data have been reported on a possible relation between antenatal mood problems and obstetric outcome. At a univariate level, differences in mean scores on questionnaires between subgroups (e.g.
The review of Dunkel Schetter and Tanner (2012) concluded that anxiety, depression and stress during pregnancy are related to obstetric complications and adverse pregnancy outcomes, like preterm birth and low birth weight [25]. However, a meta-analysis in 2007 with 50 studies found no significant evidence of an association between symptoms of anxiety during pregnancy and adverse perinatal outcomes [26], and a more recent meta-analysis with 35 studies found a significant but negligible to small relationship between stress during pregnancy and negative birth outcomes [27]. Whereas, the effect of vitamin C on conventional photodynamic therapy (PDT) of tumor cells has been documented, the mechanism of vitamin C induced increase in tumor cell response to PDT is unclear. These conflicting findings are mainly to be explained by poor methodology: regarding definition and assessment of distress, no repeated assessments during pregnancy, and lack of adequate sample power.
Further research on depression, anxiety, and stress in the different stages of pregnancy (with special attention to the concept of anhedonia) is therefore required, to investigate a possible relationship with adverse birth outcomes.Literature also shows distress during pregnancy to be related to increased request of epidural analgesia during labour [28, 29].
In The Netherlands, only a minority of women asks for epidural analgesia during delivery, although this number is increasing: from 6% in 2004 to 18% in 2012 [30, 31]. Participants receive the questionnaires by postal mail or internet according to the womana€™s personal choice. One sample will be used for explorative factor and reliability analysis (Cronbacha€™s alpha).
On the other hand, epidural analgesia has been associated with increasing numbers of instrumental delivery (hormonal stimulation because of weakening of contractions, or ventouse) [32]. If a woman does not respond within one week, a researcher of the study team (CB), will call her to inform whether she received the questionnaire and check her email or postal address if this was not the case.
A principal component analysis with oblimin rotation and a scree test will be used to select factors for retention. In this report we demonstrate the presence of vitamin C during photo-oxidation of MC540 significantly increases its apoptotic activity in tumor cells.
After checking the contact information, the women will receive a reminder email (or reminder call). Interestingly, we observed that the presence of vitamin C during photo-oxidation of MC540 only and not its addition to a prior photo-exposed mixture to MC540 is critical for its enhanced sensitivity.
Up to 10% of the women of fertile age have antibodies against thyroid peroxidase enzyme (TPO-Ab).
If a woman does not respond a€“ despite having received a written informed consent a€“ she is regarded as lost to follow-up. The TPO-Ab are involved in the autoimmune thyroiditis process resulting in an inactive thyroid.
Internal consistency analyses will be conducted using Cronbacha€™s alpha for the total scale and possible subscales derived from factor analysis. These findings provide impetus to the approach in developing ROS generating small molecule compounds with potent apoptosis inducing activity.
These women have a 4 fold increased risk for abortion and a 15a€“20 fold increased risk to develop postpartum thyroid dysfunction [35, 36]. Cronbacha€™s alpha reliability statistic ofa€‰a‰?a€‰0.70 is considered as the minimum acceptable criterion of instrument internal reliability [81].
These data could have implications in the use of vitamin C in photo-sensitizer-mediated reactions with the view to favorably tailoring the cancer cell milieu for efficient apoptotic execution. Impaired thyroid function a€“ especially high TSH referring to subclinical hypothyroidism a€“ has been related to preterm birth, intrauterine growth restriction (IUGR), small for gestational age (SGA), and pre-eclampsia [37]. In a similar second sample confirmative factor analysis (CFA with AMOS, IBM) will be used to test stability of the factor structures as found in the first sample. Maternal thyroid hormone is especially important for the developing central nervous system (CNS) of the foetus.
The comparative fit index (CFI), normed fit index (NFI), and the root mean square error of approximation (RMSEA) are generally considered good parameters to evaluate model fit. Many patients are still not discussing their CAM use with their doctors and are using CAM alongside their conventional medicines, thereby increasing the likelihood for potential interactions. However, as shown in a recent review, most studies looking at foetal outcome and maternal thyroid function did not use intra-uterine foetal parameters to evaluate the CNS development, such as ultrasound data [38]. One limitation of this study is that our ability to determine between-site differences is limited by the difference in sample size. Electrodermal measures as clinical markers: Jing-point electrical impedance in adolescent women with chronic pelvic pain. In The Netherlands, as part of antenatal screening, every pregnant woman receives a standardized and extremely well protocolized ultrasound (SEO) at 20 weeks of pregnancy. Similar procedures will be used for other new questionnaires with the assumption that four to ten participants per item with a minimum of 100 participants are needed for adequate analysis [81, 84].At a multivariate level, different techniques will be used. During the SEO, the foetal CNS is a special focus of interest including assessments of ventricle size, cerebellum size, and spine development. In order to evaluate possible causality between different variables path analysis will be performed using structural equation modelling (SEM).
Also the femur length, abdominal circumference, head circumference, and biparietal diameter are measured as objective parameters of foetal growth.
For continuous dependent variables (for example PUQE scores or depression scores on the EDS) linear regression models will be used. Consequently, skin electrical measures at Jing points are commonly obtained and interpreted for diagnostic purposes. Stepwise regression analysis will be performed, starting with the independent variable in a first model. Denise Adams, University of Alberta, 1047 RTF Building, University of Alberta, Edmonton, AB, T6G 2E1, Canada.
Moreover, maternal thyroid dysfunction has been related to abnormal foetal position such as breech and problematic cephalic position, both in turn related to obstetrical complications [39, 40].
Subsequently, block entry with different confounders will be used to calculate the total explained variance (R2) and Cohena€™s effect size.
The objective of this study is to determine whether electrodermal measures at Jing-points are associated with clinical outcomes in adolescents with chronic pelvic pain in a randomized, sham-controlled acupuncture trial. Also, thyroid dysfunction in general a€“ during pregnancy and the postpartum period a€“ has been related to mood disorders [41, 42]. For these analyses, the EDS scores will be used to define depression as well as the subscales depression and anhedonia.
Methods: We recruited 18 adolescent women aged 13 to 22 years of age suffering from chronic pelvic pain and laparoscopically diagnosed with Stage I-III endometriosis. This is partly to be explained because some associations have been found in large epidemiological studies that were not intended to investigate a specific role of thyroid dysfunction on obstetric outcome and as a consequence a substantial number of confounders were not taken into account [43]. Other studies with an adequate design suffered from poor epidemiological power (few cases of thyroid dysfunction and obstetric complications) [44]. Furthermore, a multiple linear regression analysis will be performed, with BCTQ score (indicating CTS severity) as dependent variable and fluid retention during pregnancy as independent variable, adjusted for age, parity, BMI, and depression.Linear mixed effect models will be used to determine the effect of scores on the EDS and the GAD-7 during different trimesters on the request for epidural anaesthesia during labour, obstetric complications, the occurrence of postpartum depression, and the start and continuation of breastfeeding.
Using a Hibiki-7 device, normalized electrical impedance values were obtained at all 24 Jing-points for each treatment session. Large prospective studies in which thyroid function and psycho-social characteristics have repeatedly been assessed during pregnancy are scarce. Linear mixed effect models are able to adjust for missing values and are therefore used to avoid loss of information [85].For answering the various research questions, different models will be used containing different dependent and independent variables.
Phase II: CAM research networks in Canada and the US will notify CAM providers of this study, so they may alert patients.
Left-right asymmetry and measures for statistical dispersion (standard deviation and Gini coefficient) of Jing-point impedance values were calculated.
Moreover, adding a biological variable (thyroid function) to a model with predominantly psychological variables (maternal depression and anxiety during pregnancy), may elucidate on the multifactorial origin of impaired infant development as has been published before by our research group [45, 46].The early postpartum periodNeonatal thyroid functionAfter birth, there is a neonatal TSH surge to stimulate neonatal thyroid function in order to start brown fat production for thermogenesis. Parents or legal guardians may self-identify and reply on behalf of patients under 18 year of age if they meet the criteria for Phase I. With a generalized estimating equation method, we evaluated the association between the electrodermal-derived measures and clinical outcomes while accounting for treatment designation and time. The umbilical blood vessels are thought to accurately reflect neonatal thyroid function before the TSH surge starts and assessment of thyroid function in the umbilical cord will reflect maternal thyroid hormone function during the last trimester [47, 48].
The variables age, parity and educational level will be used as confounders in all the models.
As in most Western countries, in The Netherlands, there is a nationwide congenital screening program of neonatal thyroid function between three to five days postpartum. Phase III: The methods for phase II were utilized but CAM associations and training organizations were substituted for CAM research networks. Until now, little is known about the relation between maternal thyroid hormone levels in pregnancy, umbilical cord levels, and neonatal heel screening results. Within the HAPPY study, pairs of maternal and neonatal thyroid data will be sampled to investigate whether poor maternal thyroid function has neonatal thyroid function consequences. The majority of the cases involved the use of Traditional Chinese Medicine to improve quality of life. From previous research in the same area it is known that because of logistic difficulties (home delivery, referral during labour from home to hospital, delivery in different hospitals) in about 70% of the participating women umbilical cord blood will be obtained [47].Maternal well-being and infant development during the postpartum periodUp until now, it is unknown how long the period lasts that a woman normally needs to recover from pregnancy and delivery. Similar to pregnancy, there is hardly any insight into complaints and symptoms that occur during the postpartum recovery period: what are typical complaints and symptoms for this period, how long does it last, when does it end, is it related to feeding sessions at night, or to complicated delivery? As a consequence, many physiological signs and symptoms which seem to be typical for the postpartum period (cognitive and sleeping problems) are incorrectly related to postpartum depression, which is generally regarded as a stigmatizing condition.
Postpartum mood disorders mostly refer to postpartum blues (occurring in 40% to 80% of the women preferentially during the first postpartum week) and postpartum depression with prevalence between 13-19% [49]. Preliminary analyses indicate that, over time, subjects in the active acupuncture arm were more likely to have reduced left-right asymmetry and statistical dispersion of Jing-point measures compared to subjects in the sham-control arm. The negative effect of (especially a€?chronica€™) maternal depression on the developing child has extensively been described [50a€“53]. Depressed mothers may become apathetic, emotionally withdrawn, and unresponsive to their offspring [52], while the first months of the newborna€™s life are the a€?sensitive perioda€™ for the mother-child bonding [53].
Further analyses with multivariable models will be performed to assess whether this difference is statistically significant for each electrodermal measure. Maternal postpartum depression is harmful to the development of the newborn, whose early socialization, cognitive development, and speech acquisition are largely in mothera€™s hands [52].However, research that assesses maternal distress on a regular basis during pregnancy and during a substantial period of time during the postpartum period is scarce. For example, only about 38% of infants aged up to six months worldwide are exclusively breastfed [54]. In The Netherlands, about 75% of the women start breastfeeding after childbirth but almost half of them has stopped within the first three months postpartum and less than 25% still breastfeed at six months postpartum [55, 56].
In Norway and Sweden, more than 95% of the women start breastfeeding and 67-80% of these Scandinavian women still breastfeed at six months postpartum [57, 58].
The chiropractic care of children with otitis media: a systematic review of the literature utilizing whole systems research evaluation and meta-synthesis.
Determinants that predict start and continuation of breastfeeding are of multifactorial origin including educational level, socioeconomic status, marital status, partner involvement, and maternal distress during gestation and postpartum [59]. Joel Alcantara, International Chiropractic Pediatric Association, 327 N Middletown Rd, Media, PA 19063. Also, facilities at work to breastfeed [60] and the perceived milk supply [61] influence the duration of breastfeeding. When women are depressed during pregnancy, they are less likely to initiate or to maintain breastfeeding [62, 63]. However, the relation between postpartum depression and breastfeeding remains equivocal [63]. Key words were otitis media and related words (ie, acute otitis media, otitis media with effusion, ear infections, etc) AND chiropractic. There is still the dispute whether women who discontinue breastfeeding are at increased risk for postpartum depression or vice versa: are women with postpartum depression at risk for poor breastfeeding a€?behavioura€™? It is important to detect women who experience difficulties with the challenges of breastfeeding (e.g. A narrative review of the literature was performed and augmented with a meta-synthesis of the literature with a focus on chiropractic management and the application of a whole systems research (WSR) evaluation.
Results: Our systematic review revealed 20 articles consisting of 6 case reports, 5 case series, 1 retrospective cohort, 2 prospective cohorts, 2 reviews of the literature, 2 commentaries, 1 survey study and 1 prospective, parallel-group, observer-blinded, randomized feasibility study. Antenatal intervention techniques (including involvement of the partner in decision making) can increase the likelihood to breastfeed [64].Moreover, the effect of epidural analgesia during labour on the start and continuation of breastfeeding during the early postpartum week is poorly understood. Due to the lack of higher-level research design, a meta-analysis of the literature was not possible.
A recent study showed a 26% increased risk of not initiating breastfeeding after epidural anaesthesia in primiparous women who delivered vaginally [65].
Similarly, it has long been noticed that oxytocin also has an impact on the CNS, and oxytocin and vasopressin are hypothesized to integrate social information into attachment processes. This included the use of otoscopy and tympanogram to provide objective pretreatment and comparative outcome measures. There is growing evidence that oxytocin might be useful as an antipsychotic drug in the future. Eighty-nine percent of respondents reported treating pediatric patients; patients under the age of 17 made up 12% of chiropractic and 20% of both naturopathic and osteopathic patients. Activator, Gonstead, Toftness, Chiropractic Biophysics, and Diversified Techniques were utilized with an emphasis on the upper cervical spine (the C1 or C2 vertebral bodies).
These days, synthetic oxytocin is the most common medical intervention in childbirth, despite the great variety of plausible side effects [66]. Approximately two-thirds of both osteopaths and naturopaths disagree or strongly disagree that immunizations are safe compared to one-third of chiropractors. One paper described utilization of cranial technique, 2 papers described a dietary intervention, and 2 papers utilized soft-tissue massage to augment spinal manipulative therapy.
There are theoretical reasons to test whether the increasing incidence of breastfeeding difficulties and the earlier than desired cessation of breastfeeding are related to the use of synthetic oxytocin during labour [66].
Fifteen studies were amenable to the WSR evaluation resulting in a score of 7.06 from a maximum of 11. The immunizations of most concern to the 3 professions included MMR, varicella, influenza, DPTP, and hepatitis. The most common reasons for concern were related to safety, including that vaccines may contain dangerous ingredients, may produce side effects, and may be linked to future problems such as neurological damage. Conclusion: This systematic review highlights the need for more higher-level research designs in addition to incorporating new methodologies (ie, whole systems research) reflective of the holistic and vitalistic clinical and theoretical framework of chiropractic.
Both a psychological and a physiological model will be tested to explain the variance of (severe) NVP and CTS symptoms (Figure 1). The chiropractic care of children with enuresis: a systematic review of the literature utilizing whole systems research evaluation.
Significantly more naturopaths advised parents against vaccinations (27%), compared to 10% of chiropractors, and 12% of osteopaths (P=.0002). Joel Alcantara, International Chiropractic Pediatric Association, 327 North Middletown Rd, Media, PA 19063.
There was no significant difference between groups for those advising parents in favor of vaccinations (15% C, 14% N, 6% O) (P=.1143).
Key words were enuresis, nocturnal enuresis, bedwetting as well as related words AND chiropractic. A narrative review of the literature was performed and augmented with an evaluation using WSR evaluation. Results: Our systematic review revealed 7 articles meeting the eligibility criteria for review.
Four of the 7 papers involve case reports describing the care of children aged 8 to 14 years with primary complaints of nocturnal enuresis. Spinal manipulative therapy involved the use of Toggle recoil, Sacro-Occipital Technique, Activator Methods, Gonstead Technique, and Diversified Technique to address primarily segmental dysfunctions in the lumbosacral spine. We conducted a systematic review to assess the nature and severity of adverse events associated with pediatric acupuncture.
A large prospective cohort study (N=171) demonstrated improvement in wet nights per week from baseline following 2 weeks of care. In a randomized clinical trial, within-group comparison of pretreatment and comparative rates of enuresis subjects demonstrated an improvement.
However, the study was fraught with research design issues such as randomization and biostatistics.
Six of the 7 studies were amenable to WSR evaluation and resulted in a scoring of 7.33 from a maximum possible score of 11 points.
One reviewer screened all articles, while the second reviewed all excluded articles to ensure that no article was inappropriately excluded.
Full articles of potentially relevant references were retrieved and assessed by two independent reviewers.
The use of Whole Systems Research provides promise in contributing to evidence-based practice and reflects the holistic and vitalistic chiropractic approach to patient care. Results: Seven thousand, two hundred sixty-two potentially relevant articles were identified. Eleven of these studies included adults as the majority of patients; for these studies the age of the patient experiencing the adverse event was never reported. Most of the adverse events that have been identified in children were mild and included pain, bruising, and worsening of symptoms. The few adverse events rated as moderate or serious included one pneumothorax, 2 infections, and 2 cases of complications from needles left in the body. Methods: This study was approved by the Institutional Review Board of Life University (Atlanta, Georgia).


A 26-item questionnaire was sent to 9000 subscribers of an online newsletter from Midwifery Today Magazine.
The first domain identified demographics (midwife credentials, age, years in practice, and place of practice).
The second domain queried participants regarding their formal and postgraduate training on the subject of chiropractic.
The third domain attempted to identify their experience (ie, positive or negative experience) with chiropractic personally and professionally as it pertains to pregnancy and infant care.
The fourth domain asked their opinion about the safety of chiropractic care for pregnant and pediatric patients.
The fifth domain surveyed their knowledge regarding the scope of practice of chiropractic for pregnant and pediatric patients. The respondent ranged in age from 41 to 50 years with practice experience ranging from 6 to 10 years.
With respect to their training on chiropractic, 31% (n=57) reported receiving formal education (ie, during midwifery education) on the subject of chiropractic. Fifty-five of the 157 who did not indicated receiving some education on chiropractic through continuing education seminars. With respect to the midwife responders’ experience with chiropractic, 95% (n=176) admitted to making a professional referral to a chiropractor with 73% (n=137) having referred an infant to a chiropractor. Ninety-two percent (n=171) reported being chiropractic patients with another 58% (n=124) presenting their child for chiropractic care. Over 90% indicated experiencing a positive experience as patients and with their child’s care. All of the respondents perceived chiropractic was safe for pregnant patients, while only 97% considered chiropractic safe for children. An overwhelming majority of the responders (98%) indicated that chiropractors work with birth professionals, while 92% indicated that they were knowledgeable about the role of chiropractic in prenatal care. Lastly, 75% indicated interest in learning more about chiropractic, with 86% wanting more evidence-based practice chiropractic. From the 809 articles reviewed, 18 articles met the full inclusion criteria and proceeded to data extraction. Identified adverse events include local pain or soreness, swelling, mild fevers, and skin rashes.
Thus far, the majority of adverse events reported have been mild with few moderate or serious adverse events occurring in pediatric patients. Total weight and body composition changes in response to weight reduction diets of varied protein content in midlife women.
Age-related changes in body composition for women include loss of lean mass and gains in total weight, fat mass and central fat deposition. There is growing evidence that diets with low-to-moderate carbohydrate and fat content and increased levels of high-quality protein are effective for weight loss.
Greater subjective satiety is reported by subjects following test meals containing whey protein compared to other protein sources. The beneficial effects of whey protein on satiety, thermogenesis, and lean body mass protection suggest that whey may be a preferred protein source for weight loss treatment. The specific aims of this study are to assess weight loss in subjects receiving energy-reduced dietary regimens and to evaluate parameters of weight and body mass change between the 3 treatment groups.
Study Design: We are conducting a randomized, controlled pilot feeding study to evaluate the effect of different dietary protein sources on weight loss.
Endpoint measures include body weight and body composition data obtained at baseline and at 8 weeks for dietary treatment.
The HP diet and the WP diet produced greater total fat loss and less total lean tissue loss than the CD. Conclusions: Preliminary data shows that across treatment groups, the high-protein diets conserved lean tissue and promoted reduction of fat tissue. Trials investigating TCM must be conducted with increased methodological rigor to be of value in evaluations. The single included study suggesting that acupuncture may be safe and efficacious in CFS is limited in applicability by the use of sham acupuncture as the control. Integration and interface between naturopaths and conventional rural care: empirical findings from a grass-roots research project. The worsening epidemic of DM in the United States, along with the increasing prevalence of obesity, insulin resistance, and IGT, render the identification of promising interventions for these states a matter of some urgency. Jon Adams, University of Queensland, School of Population Health ,University of Qld, Herston, Queensland, 4006, Australia. While lifestyle interventions based on dietary pattern and physical activity can delay or prevent the onset of diabetes and reduce cardiovascular risk, adherence at the population level is severely limiting.
Pharmacotherapy offers promise for diabetes prevention, but with associated high costs, unacceptability to many patients, and potential toxicity. In this context, the potential role of chromium (Cr), an insulin cofactor, in IGT is of great interest. Proposed, therefore, is a randomized, double-blind, placebo-controlled pilot trial conducted at the Yale Prevention Research Center to investigate the effects of daily Cr for 6 months at 2 dose levels on serum measures of glucose tolerance and on endothelial function in adults with IGT, IFG, and IR. The study is powered to detect a clinically meaningful effect of Cr supplementation at either dose on glucose control, and to compare the two doses for equivalence. The study will investigate effects of Cr on both measures of glucose tolerance (glucose, insulin, OGTT) and brachial artery endothelial function, thus combining serum measures with a physiologic test of Cr effects on the vasculature. The proposed study will generate much needed data regarding the efficacy of Cr in those at risk for type 2 diabetes and offers the promise of guiding practice, as well as directing future study. By contributing to knowledge related to potential diabetes prevention strategies, this study addresses one of the more pressing public health issues in the United States today. Risk to human subjects in this study is a minor increment over minimal due to the administration of nitroglycerin as a control in BARS testing.
Secondary outcomes: (4) It will show improved well-being, as measured by elevated melatonin and DHEA.
Unlike many relaxation therapies, energy healing requires no participation by the patient, a feature that makes it particularly attractive in the hospital setting, where patients are often anxious, depressed, in pain, or sedated.
Despite the increasing use of energy healing, few studies have looked at its benefits and even fewer at its underlying mechanisms of action. In this pilot study, we examined the effects of an energy healing modality known as Reiki on the autonomic nervous system (ANS) and the hypothalamus-pituitary-adrenal (HPA) axis, both of which participate in the stress response and stress-induced pain and disease progression.
Subjects rested for 10 min before baseline heart rate and blood pressure were measured and blood was drawn to determine cortisol, ACTH, and DHEA levels, using commercial immunoassay kits. Subjects then received a 30- to 45-min Reiki or Pretend Reiki session followed immediately by post-session heart rate and blood pressure measurements and at 2h by blood draws. When asked whether they thought they were in the Reiki or Pretend Reiki group, about 70% of the participants reported that they believed that they had received a true Reiki session.
This suggests that the beneficial effects of Reiki on physiology, as compared to the Pretend Reiki, cannot be explained solely by the placebo effect.
Issac Amponsah, Faculty of Pharmacy Kwame Nkrumah University of SC, Knust, Kumasi, 233, Ghana. Effects of ultra-low dilutions of sabal serrulata on human prostate cancer growth: mechanistic studies. Hakima Amri, Georgetown University, Basic Science Bldg, 3900 Reservoir Rd NW, Washington, DC 20007.
Finally, serum protein differential expression was carried out using 2-dimensional gel electrophoresis followed by mass spectrometry analysis.
Effect of mind-body medicine skills on elements of emotional intelligence in medical students. Yet studies have reported that traits such as altruism and empathy tend to decline throughout medical school training. In an effort to foster medical student self-awareness and mindfulness, which may improve their EI, Georgetown University School of Medicine (GUSOM) offers an experiential course to undergraduate medical students in mind-body medicine skills.
The purpose is to expose students to a variety of mind-body approaches including meditation, imagery, as well as group sharing and listening generously for self-awareness and reflection. The aim of this study was to assess the impact of the Mind Body Medicine Skills (MBS) course on perceived stress, mindfulness, and elements of EI including intrapersonal capacities (attention to feelings, mood repair, clarity of feelings) and interpersonal capacities (perspective-taking, empathetic concern, and personal distress in response to distress in others).
The intervention group (n=30) was comprised of first year medical students who self-selected to participate in this elective.
The control group (n=36) included students from the first year class who completed the surveys but did not take the MBS course. Four questionnaires were completed at the start and end of the spring semester by all study participants: the Perceived Stress Scale (PSS), the Mindful Attention Awareness Scale (MAAS), and a survey of EI developed by Stratton et al (2005) comprised of the Trait Meta-Mood Scale and the Interpersonal Reactivity Index. ANCOVA was used to compare the MBS and the control groups at the end of the semester, controlling for beginning scores. Patient perspectives of integrative and primary care management of back and neck paina€”qualitative findings from a randomized clinical trial.
These conditions are additionally some of the most common reasons why patients use complementary therapies, often without dialogue with conventional care providers. The focus groups were conducted separately for those in the integrative vs the conventional treatment groups.
The interview data were transcribed ad verbatim and analyzed utilizing inductive content analysis technique. Eliane Angst, UCLA Center for Excellence in Pancreatic Diseases, 675 Charles E Young Drive South, Los Angeles, CA 90095.
A significant reduction in cell numbers was seen with quercetin concentrations of ~30 AµM and a maximum effect at ~75 AµM. In MIA PaCa-2 cells a ~65% reduction in cell number was seen with 75 AµM of quercetin after 48 hours. Starved BxPC-3 cells treated with 75 AµM quercetin showed a ~95% reduction in cell number after 48 hours.
Conclusion: These results suggest that quercetin has a potent growth-inhibitory effect in pancreatic cancer cells in vitro.
Additional experiments to investigate the underlying mechanism of growth inhibition and animal studies are underway.
Flovanoids may reveal to be potent anticancer drugs found in our daily food, leading to specific diet recommendations. These can be taken together to qualify as an academic minor in many of the conventional MA or PhD programs, often forming the basis of a thesis or dissertation required for the terminal degree. In the fall of 2009, the university will launch a doctorate of nursing practice with a focus in integrative health and healing. Georgetown University developed a concentration of CAM within its Masters in Physiology program in 2003. We address the multicultural perspective, comparing data collected in Canada and Europe to those in the United States. The reason for this is that results on the health-promoting effects of spirituality and religiosity cannot easily be transferred from the United States to countries with different cultural and religious backgrounds. Thus, one has to recognize different concepts of spirituality, different attitudes towards its utilization, and objections against the implementation of it in a particular medical system. In Germany, 3 colleagues have founded the Transdisciplinary Working Group on Spirituality and Health, and in Canada the Canadian Research Network on Spirituality and Health has been active for a couple of years.
Data and approaches from these different networks will be combined into this symposium.Dr BA?ssing is an associate professor at the University of Witten, Herdeckea€™s Faculty of Medicine, where he directs the research group Spirituality and Health. The effect of a€?acupuncture for losing weighta€? on the level of blood sugar: a survey on the mechanism. Hoda Azizi, Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, Beijing, Beijing, 100029, China. Material and Methods: In this clinical trial study, 66 patients were included in case and control groups.
Blood sugar was examined just before inserting needles and immediately after withdrawal of needles.
Conclusion: Our results suggest that the mechanism of acupuncture in losing weight is significantly related to making an increase in BS. John Balletto, Center for Muscular Therapy, Inc, 545 Pawtucket Avenue, Mailbox 304, Pawtucket, RI 02860-6046. As with business startups that begin informally and successfully mature into larger enterprises, growth brings new organizational challenges, together with greater visibility and opportunity. The maturation of massage as a healthcare profession increases the need for a process to formalize the synthesis of massage therapy knowledge from clinical experience and research—to collect what we know and to make such baseline knowledge widely available to practitioners, consumers, and other healthcare stakeholders. The present paper lays out the motivations and framework for creating massage therapy guidelines that are informed both by research and by clinical experience. It also acts as a report to the massage therapy profession and to other stakeholders about the work of the Best Practices Committee of the Massage Therapy Foundation since 2006.
And it has the additional goal of providing a healthcare literature basis for future academic discussions of massage. The discussion here is based on a definition from the Institute of Medicine and on research into the nature of expertise. Topics addressed include guideline creation, credentialing of complementary and alternative medicine practitioners, definition of competence, and the increasing role of technology (that is, informatics) in managing training and task-necessary competencies. The roles of transparency and a wide and open peer review are emphasized as essential to the usability and credibility of guidelines. Health Canada issues consumer advisories regarding the safety of marketed health products, yet the criteria for issuing advisories have not been evaluated for consistency or objectivity.
The Causality Algorithm used by Health Canada was used to rate degree of association between the adverse events (AEs) and the products.
The Severity of Adverse Events Scale, developed by the National Cancer Institute, was used to determine the severity of the AEs. Most NHP AWRs were issued based on potential AEs from contamination and adulteration, whereas most of the AWRs for therapeutic drugs were issued due to actual AEs. Of the 6 NHP AWRs issued for actual AEs, 3 (50%) were unassessable for severity, whereas of the 28 AWRs issued for actual therapeutic drug AEs, 1 (3%) was unassessable for severity.
The origin of reports for NHPs tended to be from foreign sources or Health Canada, whereas reports for therapeutic drugs were mostly issued by Health Canada in conjunction with drug manufacturers. The potential of a mistletoe (Viscum album L) extract to alleviate adverse effects of cancer chemotherapy: an in vitro study.
Stephan Baumgartner, University of Bern, Institute of Complementary Medicine KIKOM, Inselspital, Bern, BE, 3010, Switzerland. We investigated the effect of a mistletoe extract on PBMC with and without concomitant treatment with cyclophosphamide and compared viability and replication of normal PBMC with that of a T-cell leukemia cell line. The results motivate further preclinical and clinical investigations of mistletoe extracts as an adjuvant medication in cancer therapy to alleviate side effects of conventional therapy. Stephan Baumgartner, Institute of Complementary Medicine KIKOM, University of Bern, Inselspital, Imhoof-Pavillon, Bern, BE, 3010, Switzerland.
We investigated the potential of a commonly used plant pathogen–system, Arabidopsis thaliana infected with the virulent bacteria Pseudomonas syringae (pv tomato strain DC3000), regarding its response towards a homeopathic treatment.
Compared to Bion (a common SAR inducer used as positive control), the magnitude of the treatment effect of Biplantol was about 50%. None of the other tested preparations yielded significant effects in the overall evaluation. The purpose of this study was to determine remedy effects on a common quantitative measure of complexity, the correlation dimension (D2), of human sleep electroencephalography (EEG). High Hostile subjects increased complexity at C3 and Pz, but decreased complexity at O2 during stage 3 sleep on CC. In the high Anxiety-Sensitive subjects, CC caused significant increases in complexity at Pz and O1 during stage 3 sleep and at C3, C4, and Pz during stage 4 sleep.
CC increased complexity significantly at Cz, C4, and O2 during REM sleep in only the high Anxiety-Sensitive subjects. The purpose of the present study was to determine whether or not the objective measure of polysomnographically-recorded all-night sleep recordings can distinguish verum homeopathic remedies from placebo in human subjects.
NV produced more marked effects on increased shifts in sleep stages, with a growth in effects from night 22 to 23.
This study examined the effects of olfactory administration of a polycrest homeopathic remedy Sulphur on heart rate variability (HRV).
The Sulphur was given at dilution factors used for preparing 6c, 12c, and 30c potencies (1 potency per session, with potency order randomized), but for each potency, the test solutions were succussed to different degrees (stirred without shaking, 10, 20, or 100 succussions). Homeopathic remedies increase spectral electroencephalographic power during sleep in healthy young adults. The purpose of the present study was to assess the effects of verum vs placebo homeopathic remedies on spectral qEEG measures of polysomnographically-recorded all-night sleep recordings.
Evaluating a nonlinear dynamical model for human flourishing: Relationship of PANAS positive-to-negative-affect ratio and global health and well-being. The purpose of the present study was to compare global physical health (GPH) and well-being ratings of young adults whose P:N mood ratios fell above vs below the Losada line. Despite higher (MCSD) scores in PF, a small sex and age difference between groups, ANCOVAs controlling for MCSD, sex, and age still showed statistical significance of the above PF vs PL group differences.
Gurjeet Birdee, Osher Research Center Harvard Medical School, 401 Park Drive, Suite 22-A West, Boston, MA 02215. We identified the prevalence of CAM modalities used and the characteristics of users among the pediatric population.



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