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By age 40, nearly 90% of adults have been exposed to the herpes simplex virus-1 (HSV-1), which causes cold sores. Until now, research has generally concentrated on keeping HSV1 inactive — and preventing cold sores from ever showing up. Understanding how to override the microRNA could allow scientists to activate the virus and then kill it using acyclovir. The theory is that by activating the virus, then preventing it from returning to hibernation, which is when researchers think it gains strength, it can be completely eradicated. Cullen and his colleagues, as well as several biotech firms, are already investigating such treatments and how best to deliver them. Cold sores cannot be healed permanently but with the help of a few natural elements, we can fasten up the process of recovering. Honey has got a natural anti-bacterial and anti-fungal property which can heal any kind of wound. Tea tree oil is very beneficial for any kind of blister as it has got antiseptic and anti-viral property. If you start doing this just with the sensation that you are going to have a cold sore, you may succeed in avoiding the appearance of the same as well. This process helps in killing the virus under the extreme low temperature. Since 1 in 4 adults suffer from genital herpes, this is only a short list of celebrities having this disease. The only reason I am mentioning these people here is because, all you guys out there battling this disease, need to understand that life goes on after being diagnosed with herpes. But the Duke researchers took the opposite tack: figuring out precisely how to switch the virus from latency to its active stage. Cullen believes that a drug could be developed to block the microRNA that suppress HSV-1 into latency; once it's active, acyclovir can be used to destroy the virus permanently.
Before starting with the natural cures, we should be aware that cold sores are different from canker sores.


You just need to dab the original and fresh honey on the cold sore to fasten up the healing process.
You should use a clean cotton ball to dab the tea tree oil on the affected area as many times possible throughout the day. Steep it for 5 minutes and squeeze out the soaked tea from the tea bag to get the complete extract.Now, let the thick black tea to cool down to room temperature. You can also wrap the ice cube in a clean tissue and use it as a cold compress on the affected areas. You accept that you are following any advice at your own risk and will properly research or consult healthcare professional. You can still be sexy, have sexual partners, merry, have babies, be sexually desirable and enjoy life.
For those who do, however, cold sores are a painful and permanent nuisance, always erupting in the same location, at the original site of infection on the lips or mouth. In its latent stage, HSV-1 produces a single molecular product, called latency-associated transcript RNA, or LAT RNA.
Cullen suggests that this new research may also eventually be applied to other latent viruses, such as herpes simplex virus-2 (HSV-2), which causes genital herpes, or the chicken pox virus, which causes shingles in adults.
Below, I will try to list down the different effective and tested natural cures for cold sores. You will feel the extreme burning sensation, but you will rise up the next morning with a shrunk and painless cold sore. Some have been accused by ex-spouses and partners of giving them genital herpes others have had sexual relations with people with herpes so by association they are consider to have it too.  And than there is thee famous Derek Jeter tree.
Keep your disease under control with the right medication for you, have a healthy lifestyle (which you should have had without the disease anyway) and continue living your life as before. Worse yet, once you're infected with the virus that causes them, you're stuck with it for good.


Once HSV-1 enters the body it hunkers down for life, most of the time hiding dormant in the cranial nerves near the spine.
Unlike most messenger RNA, LAT RNA doesn't produce proteins, so scientists have never been able to determine LAT RNA's exact function.
Cullen warns that some patients, especially those suffering genital herpes, may have to take acyclovir on a regular basis (HSV-2 is a hardier virus), but for people with HSV-1, the virus could be eradicated with just one dose.
You should do this for 2 days for complete eradication of the cold sore from the specific area. Do it once a day before going to bed for 3 days to get complete relief from the problem of cold sore.
But landmark research reported today by microbiologists at Duke University may offer the potential for a cure. The virus can be triggered by outside stress, such as exposure to sunlight, a fever or emotional distress.
But by inserting the LAT RNA into mice, Cullen found that it breaks down into even smaller strands called microRNA. After it's active and a cold sore appears, it's treatable with the drug acyclovir, marketed under the name Zovirax, which kills replicating HSV-1. Researchers then discovered that it was the microRNA that blocked production of the protein that activates HSV-1.
But the mystery has been how to eliminate the virus while it's hiding, before it produces unsightly symptoms.



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