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New York, NYContrary to common opinion, routine cervical screening can identify early-stage adenocarcinoma and adenosquamous carcinoma of the cervix, according to a large case-control study that used routine records of cervical cytology from UK databases."Although there can be no doubt about its effectiveness in preventing squamous cell carcinoma, there is little evidence of any benefit on adenocarcinoma and adenosquamous carcinoma of the cervix, and many authors have concluded that it is ineffective," Dr.
Peter Sasieni and co-investigators point out in the International Journal of Cancer for August 1.They evaluated screening histories for 3305 women, ages 20 to 69 years, with invasive cervical cancer diagnosed since 1990. The cancers included adenocarcinomas (19%), adenosquamous carcinomas (4%), and squamous carcinomas (77%).For each subject, Dr.

Sasieni, at the Wolfson Institute of Preventive Medicine in London, and co-researchers chose an age-matched control from the same group practice, and another from a different practice in the same area. They estimate that such tumors can be detected, but it may be harder to do so, and requires a shorter lead time than for squamous cell carcinoma.By contrast, the impact of screening on adenosquamous carcinoma was nearly the same as the impact on squamous carcinoma.

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