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University of Miami pediatrician Judith Schaechter gives a girl an HPV vaccination in 2011.
The HPV vaccine was created to protect women against the virus that causes cervical cancer. A vaccine that protects against four strains of the human papillomavirus (HPV), which can lead to cervical cancer, does not increase the risk of blood clots in women, new research has found. The findings in the Journal of the American Medical Association are based on a study of 500,000 girls and women aged 10 to 44 who received the HPV vaccine between 2006 and 2013.
Using data from national registries, researchers in Denmark found no evidence of an increased risk of venous thromboembolism (blood clotting) in the 42 days after the shot, which they defined as the main risk period. When researchers adjusted for use of oral contraceptives, which can increase the risk of blood clots, they found no association between blood clotting and the vaccine. The report said two earlier studies had suggested a link between the Gardasil vaccine, made by Merck, and a higher risk of blood clots. The Centres for Disease Control and Prevention (CDC) said in 2009 that there was an increase in patient reports of blood clots after the vaccination. Please note - by subscribing to this newsletter you are confirming that you are a healthcare professional working within oncology or an aligned specialty.

But it also helps prevent genital warts, a common sexually transmitted disease caused by the same virus, a study finds. Girls and women who got two doses of the HPV vaccine got almost as much protection from genital warts as people who got the recommended three doses, according to a study published Tuesday in JAMA, the journal of the American Medical Association. This study looked at the health records of more than 1 million girls and women ages 10 to 24, using Sweden's national health registry. The researchers could see when participants had had HPV shots, and when they were diagnosed with genital warts. The girls and women who got just two doses of vaccine had 59 more cases of genital warts per 100,000 person-years compared to those who had three doses.
Those questions include whether girls who start the shots when they're 11 or 12, as recommended, would get better protection against the human papillomavirus, and whether that protection wanes over time. The results echo those of smaller studies looking not at genital warts but infection with the HPV virus. If this turns out to be true it will be good news, because doctors have found it hard to get teenagers and young women to complete the recommended vaccinations.

Just one-third of girls ages 14 to 19 have gotten all three doses, the CDC reported in 2013. Cost and inconvenience are big issues, as well as parents' concerns about safety and potential effects on sexual activity.
One, called Gardasil, protects against HPV types 6 and 11, which cause 90 percent of genital warts. Though many people are able to clear the infection themselves without treatment, others have recurrent infections even if treated.Copyright 2014 NPR.

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