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Signs herpes outbreak is coming

Herpes Simplex Virus (HSV) is a member of the Herpesviridae family of viruses, a family of DNA viruses important in human disease. In addition to the common mucocutaneous infection, HSV 1 and 2 can also cause keratitis (inflammation in the eye), encephalitis (brain infection), and severe neonatal disease if acquired during pregnancy. Because HSV 2 is spread more commonly by sexual contact, it is easier to prevent than HSV 1.
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Pridgen’s patent application indicates that he believes that stressors and  peptides and hormones released by the sympathetic nervous system and HPA axis  set the stage for herpes simplex-1 reactivation. Once  these neurons and ganglia are damaged, Pridgen believes they send out signals that ultimately muck up the pain processing centers in the central nervous system. One of Pridgen’s patent applications suggests that one of his unique insights has been to combine valacyclovir (valtrex) with an anti-inflammatory, Celecoxib (Celebrex) that has antiviral properties.
Celexcoxib (Celebrex) is a non-steroidal antinflammatory (NSAID) COX-2 inhibitor usually used  in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation and menstrual symptoms. Pridgen and Duffy are looking for herpes simplex virus, but other herpes viruses could be affected by this treatment.
Pridgen and his partner, molecular virologist, Carol Duffy will also attempt to develop a diagnostic test for fibromyalgia using cytokine arrays they believe will document high levels of  pro-inflammatory cytokines and low levels of anti-inflammatory cytokines. Celebrex was shown to reduce stress induced herpes virus reactivation in the nervous systems of mice.  Another study found that reactivation of HSV-1 in mice was associated with upregulation of COX-2 gene expression in their nerve ganglia. Along with treating the virus, Pridgen and his partner, molecular virologist Carol Duffy, will be using PCR to test for the virus, not in the blood, but in gut tissue samples. One of the most intriguing aspects of the Pridgen-Duffy study is the search for HSV-1, not in the blood, but in the tissues. Pridgen and Duffy’s big multi-center antiviral trial in Fibromyalgia is nothing if not exciting in its scope and approach. If they results are positive, Pridgen and Duffy could usher in an entirely new way of treating both fibromyalgia and chronic fatigue syndrome. This indeed would be good news and a blessing for those of us who suffer with Fibromyalgia!


We obviously need a drug trial that indicates these drugs do work in some patients – and that will get the drug approved by insurance companies.
I have used Cymbalta for many years and didn’t really think it was doing a whole lot until my script ran out and boy did everything go crazy. Dear Kalikim, have you tried calling the drug manufacturer’s number that quite often gives out free prescriptions? These medications can help infected individuals reduce the risk of spreading the virus to other people. But there are herbal therapies that could totally eradication this virus from the body, meanwhile there has been proofs and lot of testimonies to that effect.
The enigmatic Skip Pridgen has no published research record (outside surgery) nor is this trial yet registered.
My DP, who had had recurring shingles as an adult before, and who also was a chronic FM case, came down with viral meningitis in 2013, and was treated at the main hospital in Hilo, HI with a very heavy dose of acyclovir. I have asked my Doctors for years do they believe there is a connection between shingles (herpes zoster) and fibromyalgia. The training of the majority of conventional doctors comes from books that never covered more in-depth studies about these Herpesviruses. It scares me because I can feel the virus act up often and a few months ago I have headaches and fogginess almost every day of the month. In any case, I know this is a lot of info but I am really looking to talk to an expert virologist or other people that specialize in this and other HSV related illnesses. DNA purified using the Quick-DNA™ Universal Kit is ultrapure, highly concentrated, and ready for all downstream applications. A dilution series of HSV-1 spiked into porcine plasma and extracted using the Quick-DNA™ Universal Kit shows effective purification and subsequent qPCR amplification, even at a 20,000:1 dilution. Mix thoroughly or vortex 10-15 seconds and then incubate the tube at 55?C for 1-3 hours or until tissue solubilizes.
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The over-generation of neurotransmitters such as glutamate, Substance P, serotonin, norepinephrine, dopamine, brain-derived neurotrophic factor (BDNF) involved in this process then causes central sensitization. Pummeling the virus with that one-two punch, he believes, will finally stop the virus from reactivating.
We know the Chronic Fatigue Initiative’s Pathogen study  failed to find evidence of viral infection in the blood. Then antibodies will be used to determine if an active infection is present.  In subsequent studies, electron microscopy will look for the herpesviruses particles themselves. Pridgen reported in an email they are still trying to determine  the optimum doses and cautioned everyone to wait until the results of the phase three trial are done before starting this treatment. Pridgen’s ability to come up with over $3,000,000 in startup funding suggests he and Duffy have got some solid data backing their trial up. My pain levels shot through the ceiling, feeling of extreme aggressiveness as well as aggitation. My sister is a bio-chemist and said that anyone with any or multiple Herpes viruses needs to be on a high immune-supportive diet.
I’d be calling the bluff EXCEPT that I agree with the theory, and my figures for efficacy of these two meds individually are damn good.
During an outbreak I experienced 2 years ago, I discovered that Olive Leaf extract stopped the blisters from emerging fully, and worked better than acyclovir. Like you I used to be known for my energy and really don’t feel the same as I did before this happened 3 years ago.
Let us know when you have cited any of our products in your recent publication and get a $20 Amazon gift code. Then he found that adding an anti-inflammatory (which also had anti-viral properties) reduced their fatigue, gastrointestinal complaints, depression and anxiety markedly and improved their energy. Immunoblot testing indicated that an active infection was present in eight of nine positive biopises.
I was browsing through the Internet searching for remedy on this embarrassing disease and i eventually saw comments of people talking about how Doctor Oduduwa has cured them. Hence the combo will be a winner, but now I gotta know – how do you get $3.3m for an idea out of leftfield?


I believe it was still an antiviral and a COX-II inhibitor but I don’t know which ones. I kept telling my doctor that I could feel the virus acting up even if I didnt always get an outbreak.
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I have no insurance so I will not benefit from these drugs, but was on Valtrex and had total remssion from all health problems for 6 months out of the last 12 years. Pridgen and his studies at the time, however since my DP is reacts badly to COX-2 inhibitors, we didn’t try that part of the treatment.
I can’t imagine living the rest of my life with this disease and all the other diseases it brings with it or vice versus.
I came down with eczema herpeticum three years ago (a herpetic infection of my eczema.) Doctors often misdiagnose it and I was given THE WRONG medications (antibiotics) which actually help the virus to spread. I can feel it in my central nervous system and running along the nerves of my face (where the big outbreak started three years ago). They thought I had hives and I wasn’t given antivirals until day 4 and by that point I kind of looked like a shrapnel victim with what I now think were HSV1 sores (although blood tests apparently said I had herpes zoster antibodies) all over my face, arms, stomach and legs. It can seem to happen from just too much coffee or someone playing loud music that makes my nerves act up. Oduduwa God will give you a long life, you shall not die before your time for being a sincere and a honest man. Unfortunately he still suffers from killer back pain, which doctors are starting to look at a full sacralization with his L5 vertebrate (since his MRI shows very little) as the source of the pain.
Doctors seemed to think that after the two week daily does of vacycolvir I would be fine, and the outbreak was never that bad again, BUT I started getting bi-weekly to monthly coldsore outbreaks and in different places on my body (under my armpit, on my leg, on the back of my neck, on my finger, in my eyes etc.) I had the one under my armpit cultured and it came back as HSV1. When I tell her this because there is no physical evidence of an outbreak she just acts like I am imagining things and being a neurotic woman. ALL, I repeat ALL of my Herpes, Shingles, cold sores and chronic pain, IBS were under control and I did not relapse until I ran out of Valtrex. I was an avid walker and have tried to push through but the pain just gets progressively worse. I am WAY looking forward to the first week in March when the results to this Phase II study are given and trust you stand ready to avail us of the findings. However, there is not necessarily a connection between lower back pain and sacralization so attempts are being made to eliminate it as a source of the pain. At this point in my life, I would be willing to try the Valtrex with the hope of granting me a level of functionality for whatever time I have left. Pridgen now proposes back pain as possibly caused by VZV or HSV-1 does not surprise me, and it’s something I guess we need to look into. The b12 deficiency makes sense with the chronic HSV1 outbreaks because b12 is apparently used to build nerves.
Hopeful that a doctor might possibly be willing to spend the time reviewing the info on this site and give it a try. I am at my last wits end with my chronic painand have no insurance so I load up on as much psyche meds as aI can get.
Just make sure that the lab that draws your blood makes all the correct hook-ups so that your sample arrives via courier within 24 hours to each location. I AM TOTALLY CONVINCED THAT THE hERPES AND sHINGLES SUPPRESSESS THE IMMUNE SYSTEM SO BADLY THAT THE WHOLE BODY MALFUNCTIONS. All they want to seem to do is to stop the pain long enough to take away his pain medication. My step sister is a bio-chemist and says a high protein, high immune supportive diet like lots of Vit C will also help. Since COX-2s are not used by him, I suppose that the Valtrex may not be enough for this part of the problem.



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Comments
  1. KacokQarishqa 17.09.2013 at 15:59:42
    Medication considerably inhibited herpes and loves me for me 85.
  2. Glamour_girl 17.09.2013 at 14:18:59
    Antagonistic reactions reported by sufferers receiving.
  3. Anar_KEY 17.09.2013 at 22:46:16
    Chilly sore, you possibly can the Section 1 trial of Professor Frazer's new vaccine.