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Early clinical trials in the United States have found the vaccine can prevent infection in three out of four women. An estimated 100m people around the world are infected with what is known as herpes simplex virus type 2. The virus can cause painful itching and sores that in some cases reappear years after infection. However, many people do not have symptoms and can therefore pass on the infection without knowing it. A vaccine could be of real benefit to the thousands of infants born every year with the virus.
Dr Lawrence Stanberry and colleagues at the University of Texas Medical Branch tested the vaccine on 978 women and 1,736 men whose partners had genital herpes. Each received three injections containing the vaccine or injections containing a placebo over the course of six months. The researchers found that the vaccine did not work well in women who had been infected with a related virus - herpes simplex virus 1.
GlaxoSmithKline is now recruiting 7,550 women between the ages of 18 and 30 across the US for final stage clinical trials. The UK Herpes Viruses Association said most new cases of genital herpes are actually caused by herpes simplex virus 1 - the virus that causes cold sores.
Marian Nicholson, its director, said there was a need to tackle the stigma around the virus.
Teens today may be more susceptible to one type of genital herpes infection once they become sexually active than teens in years past, a new study suggests. In the study, adolescents ages 14 to 19 who had their blood tested between 2005 and 2010 were less likely to have antibodies against herpes simplex virus type 1(HSV-1) compared with teens who had their blood tested between 1999 and 2004. The reason for the decline in HSV-1 protection among young people over the years is likely the result of improved living conditions and better hygiene, which makes young people less likely to contract oral herpes, the researchers said.
The lack of antibodies against HSV-1 in today's teens suggests that many are not becoming infected with the virus when they are children; during childhood the virus typically spreads through skin-to-skin contact. In addition, teen who lack antibodies against HSV-1 may be more likely to develop symptoms from an infection with herpes simplex virus type 2 (HSV-2), another type of herpes simplex virus that is almost always transmitted sexually, and tends to cause more severe disease than HSV-1.
In the past, doctors were taught that HSV-1 causes illness "above the waist," while HSV-2 causes illness below the waist, said Dr.

But, "for over a decade, HSV-1 has been migrating below the waist as cause of genital herpes," Schaffner said. The reason for this appears to be a decrease in protection against HSV-1 -- shown in the new study as a decline in teens with antibodies against HSV-1 -- coupled with an increase in the prevalence of oral sex, which can spread oral herpes viruses from the mouth to the genitals, Schaffner said. While fewer oral herpes infections in kids may sound like a good thing, it had the unanticipated effect of an increase in HSV-1genital herpes infections, Schaffner said. This increase could in turn lead to an increase in the future in genital herpes infections passed from mother to child during birth, Dr. The findings underscore the need to develop a herpes vaccine that protects against both HSV-1 and HSV-2, Schaffner said. Scientists should continue to monitor HSV-1 and HSV-2 antibodies in teens to better understand the changing epidemiology of the disease, and inform vaccine development, the CDC researchers said.
Incidence of herpes zoster ophthalmicus: results from the Pacific Ocular Inflammation Study.
Herpes zoster is an infection resulting from reactivation of the varicella-zoster virus (VZV) that affects peripheral or cranial nerves and usually occurs years after primary infection with the varicella (chickenpox) virus or receipt of the live, attenuated varicella vaccine.
Effect of varicella vaccine on incidence of herpes zoster in various age groups in the years after vaccination. Psychological Stress As A Trigger For Herpes Zoster: Might The Conventional Wisdom Be Wrong? GEN-003 demonstrated sustained and statistically important reductions compared to baseline in the rate of viral shedding 12 months after dosing across multiple dose groups as well as sustained efficacy at multiple dose levels across secondary endpoints measuring the impact on clinical disease. However, half of those infants who contract the virus die unless they receive powerful antiviral drugs. In this age group, the percentage of those with antibodies against HSV-1 declined 23 percent. In fact, in recent years, the virus is causing an increasing portion of genital herpes infections -- as many as 60 percent of genital herpes infections among young adults in the United States.
As a result, they may be more prone to contracting HSV-1 as a sexually transmitted disease once they become sexually active, according to the researchers from the Centers for Disease Control and Prevention. William Schaffner, a professor of preventive medicine and infectious disease at Vanderbilt University in Tenn., who was not involved in the new study.
The percentage of people with antibodies against HSV-1 declined for all age groups between the two time periods, but the biggest decline was seen among teens.

David Kimberlin, of the University of Alabama at Birmingham, wrote in an editorial accompanying the study. Cost-benefit analysis of universal varicella vaccination in the US taking into account the closely related herpes-zoster epidemiology. If we begin to see more HSV-1 infections in teens as they become sexually active "it is logical to hypothesize that we will see neonatal herpes more frequently over the next decade," Kimberlin said. Herpes zoster, also known as zoster and shingles, is caused by the reactivation of the varicella-zoster virus (VZV) , the same virus that causes varicella (chickenpox).
Clinical Manifestations of Herpes Zoster Ophthalmicus (includes Images) Yanoff: Ophthalmology, 4th ed.
Medical records were reviewed for all 173 cases of herpes zoster diagnosed among residents of Rochester, Minnesota, less than 20 years of age during the period 1960 through 1981. CDC continues to study the epidemiology of herpes zoster among adults and children and to monitor the effects of the U. All patients with acute herpes zoster ophthalmicus should receive antiviral therapy with the goal of preventing ocular complications.
Herpes zoster ophthalmicus occurs when HZ presents in the ophthalmic division of the fifth cranial nerve. The institutional investor owned 715,000 shares of the company's stock after buying an additional 222,900 shares during the period. Eli Lilly and Company (LLY) along with Incyte Corporation (INCY) released that detailed results of RA-BEACON a pivotal phase 3 global study of baricitinib, a once-daily oral treatment now under regulatory review for the treatment of moderate-to-severe rheumatoid arthritis (RA), were published today in the New England Journal of Medicine. He is an experienced writer with a precise grasp of the English language and a clear, compelling writing style. TOPIC: The incidence and morbidity of herpes zoster (HZ) and HZ ophthalmicus (HZO) , and the potential impact of varicella vaccine on their epidemiology.

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