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Signs herpes outbreak is coming

Shortterm treatment with acyclovir can accelerate the healing of an acute outbreak, and continuous acyclovir therapy is often prescribed for people with frequent recurrences. While this drug can reduce the recurrence rate by 60-90 percent, it can also cause a wide array of side effects, including renal failure, hepatitis, and anaphylaxis.
There is evidence that certain dietary modifications and natural substances may be useful for treating active Herpes simplex lesions or preventing recurrences. Herpes simplex virus (HSV) infections of the skin are caused by one of two viruses (HSV-1 or HSV-2). Herpes simplex 1 and 2 are members of the herpes virus family, Herpesviridae, that infect humans. Symptoms of herpes simplex virus infection include watery blisters in the skin or mucous membranes of the mouth, lips or genitals. As neurotropic and neuroinvasive viruses, HSV-1 and -2 persist in the body by becoming latent and hiding from the immune system in the cell bodies of neurons.
After a primary infection, the virus travels to a nerve cell ganglion where it persists in a dormant phase. While Herpes simplex can occur in seemingly healthy people, patients with cancer, acquired immunodeficiency syndrome (AIDS), and other diseases associated with impaired immune function are especially prone to such infections. For that reason, a comprehensive prevention and treatment plan should include measures designed to enhance immune function. As an essential amino-acid, lysine is not synthesized in animals, hence it must be ingested as lysine or lysine-containing proteins.
The nutritional requirement per day, in milligrams of lysine per kilogram of body weight, is: infants (3–4 months) 103, children (2 years) 64, older children (10–12 years) 60 to 44. Good sources of lysine are high-protein foods such as eggs, meat (specifically red meat, lamb, pork). The proteins synthesized by HSV contain more arginine and less lysine than proteins synthesized by host cells, and arginine is required for HSV replication.
The synthesis of enzymes necessary for the synthesis of viral DNA is not affected in the absence of arginine.
Genetic information required for the early enzymes necessary for the synthesis of DNA polymerase, as well as the inhibitors of cellular nucleic acid synthesis, are not affected in the absence of arginine. These observations raise the possibility that increasing either absolute lysine intake or the ratio of lysine-to-arginine intake would be of value for the prevention and treatment of Herpes simplex infections.
Forty-five patients with frequently recurring Herpes simplex infections received lysine (usually 312-1,200 mg per day) for periods of two months to three years. Nine patients with recurrent Herpes simplex infections received 500 mg per day lysine hydrochloride and reduced their intake of high-arginine foods.
Forty-one patients with recurrent Herpes simplex infections were randomly assigned to receive, in double-blind fashion, lysine hydrochloride (624 or 1,248 mg per day) or placebo for 24 weeks, and then the alternate treatment for an additional 24 weeks. One hundred-fourteen patients with recurrent orofacial or genital herpes, or both, were randomly assigned to receive, in double-blind fashion, 1 g lysine hydrochloride three times daily or placebo for six months; 52 patients completed the trial. These studies suggest that lysine supplementation reduces the recurrence rate of Herpes simplex infections. The effectiveness of lysine may vary according to the dosage used, the lysine and arginine content of the diet, and the efficiency of lysine absorption, which appears to vary from person to person. The optimal lysine dose for Herpes simplex prophylaxis is not known, but a reasonable dosage range is 500-3,000 mg daily. Doses up to 6 g per day are said to be safe, but long-term toxicity studies have not been conducted in humans. By comparison, the estimated dietary lysine requirement for a 70 kg human is in the range of 800-3,000 mg per day. Lysine intake can be increased by increasing consumption of lysine-rich foods, such as legumes and animal proteins, and reducing intake of lysine-poor foods such as grains and refined sugars. Short-term administration of 1-3 g lysine daily has been found to reduce the duration of attacks, with higher doses being more effective than lower doses. Some patients report that eating arginine-rich foods such as chocolate, nuts, and seeds causes them to experience herpes outbreaks, but the importance of dietary arginine as a causative factor has not been investigated scientifically. In summary, these studies suggest that lysine supplementation may be helpful in reducing the rate of recurrence for HSV infections, especially when accompanied by a high-lysine, low-arginine diet. As is the case with many natural remedies, the use of lysine for herpes has not been fully tested or evaluated for effectiveness. Lysine is an essential amino acid, meaning it is one the human body cannot produce on its own.


While there is no conclusive evidence as to the effectiveness of lysine for herpes, there are few side effects while taking supplements when compared to other remedies, making it a reasonable treatment option for those with sensitivities to more conventional therapies. As with any medicine or supplement, the use of lysine for herpes should be discussed with a doctor or another medical professional.
Side effects of using lysine for herpes prevention and treatment are usually mild, if they occur at all, and may include nausea and stomach upset. I know that there are two types of herpes-- herpes simplex type 1 (cold sores) and herpes simplex type 2 (genital herpes). Are lysine supplements more effective for one type of herpes or is it equally effective for both? If you have been researching treatment approaches to combat the herpes and cold sore virus then you are bound to discover useful information about the amino acid Lysine. Studies have shown that supplements of Lysine can reduce the frequency and intensity of herpes and cold sore outbreaks.
The outcome is likely to be improved if a supplement is taken that contains Lysine along with other nutrients that are indicated for herpes, such as Vitamin C, Bioflavonoids and Zinc, which have been proven in Clinical Trials to improve healing time and reduce the frequency of episodes.
These nutrients work cohesively together and along with Lysine can help to suppress outbreaks and strengthen the skin.
There are two amino acids that have been found to significantly influence herpes (the virus that causes cold sores and genital herpes), these are Lysine and Arginine. Lysine can be a valuable weapon in reducing outbreaks and in healing the infection quickly, whereas Arginine can provoke outbreaks and is required by the herpes simplex virus to replicate and cause symptoms.
Tissue culture studies show that Lysine works by repressing the metabolism of Arginine, an amino acid that is essential for the herpes virus to replicate and become active. For more information about the safety of taking Lysine supplements please read the article Is Lysine Safe? A healthy diet high in Lysine and low in Arginine can be helpful in reducing herpes and cold sore outbreaks.
This could include eating healthy amounts of foods rich in Lysine such as vegetables, fish, chicken, cheese, milk, brewer’s yeast and beans and avoiding foods such as nuts, chocolate, whole and white wheat, oats and gelatin, which are high in Arginine. When deciding on which brand of Lysine to take it is preferable to choose one that is manufactured from pure Lysine derived from a food source rather than a synthetic or cultured lysine and if possible, one that also contains other beneficial nutrients such as Zinc, Vitamin C and Bioflavonoids.
These compounds work in synergy with each other (in other words they work better in the body when taken together) and will also save you money in the long run if purchased in one combined tablet.
Vitamin C and Zinc help the skin to repair, regenerate and heal more efficiently and Bioflavonoids improve the absorption of Vitamin C.  These supplements can help reduce outbreaks.
Vitamin C and Zinc both have wound healing properties and Vitamin C is vital to the production of collagen (a fiber that connects and strengthens connective tissue, such as the skin).  Bioflavonoids are a natural antioxidant, free radical destroyer and immune booster. Gelatin is high in the amino acid Arginine and should be avoided due to its potential to trigger herpes outbreaks. Magnesium stearate is normally derived from beef.  We prefer not to recommend supplements which contain animal products or are tested on animals. A blended formula can also give you better results because certain nutrients, such as Vitamin C and Bioflavonoids, work better when taken together. The dose should be increased to 1875mg per day when an outbreak is coming on and until the outbreak is cleared (this is equivalent to 3 x standard 625 mg tablets), or as high as 2500mg if it is helpful. Ideally look for a Lysine supplement in 625mg tablets so that you don’t have to worry about halving tablets or taking too much on a daily basis. However, we would NOT recommend taking a dose any higher than 3000mg per day (during active symptoms only) as this should be ample enough Lysine to affect the Arginine balance and halt the virus’ activity. There was one incident where a 44 year old woman who had been taking 3000 mg of lysine per day for 5 years developed Franconi’s syndrome, which manifested as tubulo-intersistial nephritis.
It is also to be noted that when Lysine was taken in extremely high doses of 10g (10,000mg) or more per day, some people reported experiencing abdominal cramps and diarrhea. If taken at a sensible dose side-effects from Lysine are very rare, because it is an amino acid that is obtained naturally through our diet.
The lesions caused by this infection are often painful, burning, or pruritic, and tend to recur in most patients. Cutaneous Herpes simplex is characterized by painful, burning, or pruritic clusters of vesicles on the lips, oral mucous membranes, genital region, or other areas of the body. Various factors such as sun exposure, abrasion of the skin, fever, stress, fatigue, or menstruation can reactivate the virus, resulting in a recurrence at the site of the original infection. The structure of herpes viruses consists of a relatively large double-stranded, linear DNA genome encased within an icosahedral protein cage called the capsid, which is wrapped in a lipid bilayer called the envelope.
Immune system deficiencies that are more subtle, but not necessarily associated with a serious disease, might also increase the risk of experiencing Herpes simplex infections.


The ?-amino group often participates in hydrogen bonding and as a general base in catalysis.
This indicates that arginine is essential for the synthesis of the viral coat proteins and is incorporated into them. Arginine is necessary for the expression of the late viral functions concerned with the synthesis of viral coat proteins. In comparison with past experiences, recurrences were less frequent, less severe, and of shorter duration. In several cases, patients who were given a daily dose of the amino acid had fewer outbreaks and those who received high doses during an outbreak recovered faster and with fewer lesions than those who did not use amino acid therapy of any kind. Many patients have observed positive results in prevention on as low as a few hundred mg per day. Getting more than one opinion may be a good idea, as some physicians are opposed to using amino acid therapies and others swear by their effectiveness.
Most times, lowering the dosage will help to alleviate symptoms until the body becomes adjusted to receiving higher levels of supplementation.
I take it for vaginal herpes and it helps, so I think the supplement can be effective for both. It is one of the amino acids that can only be acquired through your diet (or by taking a Lysine supplement). Tip, don’t pass on the Bioflavonoids because they work in synergy with the other nutrients, making them more effectively utilized by the body. It is a building block of protein that the body cannot synthesize from other sources and therefore must be obtained from our diet.
In fact, the whole point of taking Lysine in a supplement is to reduce the levels of Arginine in the body.  So taking a Lysine supplement which contains Gelatin is not recommended. This is rare and was of course more than double the recommended dose taken over an extended period of time, however, it is important to be noted.
It is important to always follow the recommended dose, as indicated on the label of the supplement you are taking.
HSV infection of the eye results in keratoconjunctivitis, a serious condition that sometimes leads to corneal blindness. When arginine is absent, the viral messenger RNA is present in the cytoplasm, probably in association with the cytoplasmic ribosomes, but lacks the ability to continue protein synthesis.
Lesion formation was invariably associated with high arginine intake 12-36 hours previously.
In the high-dose group, there were significantly fewer recurrences during the lysine period than during the placebo period. Lysine was significantly more effective than placebo in terms of frequency and severity of lesions and healing time. Other studies have been inconclusive, but there is enough evidence to suggest that lysine may be a suitable treatment and prevention option for those suffering from herpes. Another amino acid, arginine, has been shown to encourage the growth of lesions in herpes outbreaks.
Doses as high as 8,000 mg have been suggested for the treatment of already occurring outbreaks. Also, eating a diet high in lysine for herpes treatment is also a good idea, as many times food sources are easier for the body to absorb and utilize. During an outbreak when higher levels are needed, stomach upset is usually not severe enough to warrant discontinuing use of lysine supplements. But the dose and the extent of use is important. There is no cure for herpes (neither type) but keeping the immune system strong can keep the virus dormant and help prevent outbreaks.
HSV may also cause encephalitis or other systemic infections, particularly in immunocompromised patients. Some studies suggest that using lysine to combat an excess of other amino acids may help to reduce the duration and severity of outbreaks, and to prevent them from recurring. If a severe reaction does occur, patients are encouraged to stop taking supplements and call their doctors.



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Comments
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