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When speaking of the heart benefits of L-arginine, nutritionists and supplement experts often include lysine in the conversation. Lysine, like arginine, is a ‘base’ element, the chemical opposite of an ‘acid’ element, which, technically speaking, participates in hydrogen bonding.
Lysine has also been shown to reduce anxiety, improve immune function, and facilitate muscle recovery. Our heart healthy supplement contains 5,000mg of L-Arginine, 1,00mg of L-Carnitine, 1,000mg of L-Citrulline, Vitamin D3 and Red Wine Extract.
Many sources have pointed to the fact that arginine and lysine taken together actually seem to cancel each other out. If you have any questions regarding lysine, the benefits of l-arginine or l-carnitine, or why we do not include lysine in our formula, don’t hesitate to contact us. What Our Customers say…"My kidneys are better now since I have been taking this product, and I just recommend it highly to anyone who needs to have their health brought back to normal without taking any medications.
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Lysine, abbreviated Lys or L, is one of the twenty common amino acids used by living organisms to build proteins. There are two types of acetylation processes widely occurred in proteins, N?-terminal acetylation and N?-lysine acetylation.

The first N?-terminal acetylation occurs cotranslationally by transferring acetyl moieties from acetyl-coenzyme A (Acetyl-CoA) to the ?-amino (N?) group of protein amino-terminal residues, and is found in 85% of eukaryotic proteins.
The less common N?-lysine acetylation specifically modifies ?-amino group of protein lysine residues, and it's one of the most important and ubiquitous post-translational modifications conserved in prokaryotes and eukaryotes. Analogous to phosphorylation and dephosphorylation by the action of kinases and phosphatases, acetylation and deacetylation act as a key regulatory mechanism to regulate transcription factors, effector proteins, molecular chaperones, and cytoskeletal proteins. For acetylation studies, peptides with unmodified lysines will be synthesized; however, acetylated lysines will be used to generate peptide arrays for deacetylation studies. When checked, Shutterstock's safe search screens restricted content and excludes it from your search results. Lysine, like arginine, is an essential amino acid, meaning that the body does not produce this element but can be supplemented with it. It is a needed building element for much of the protein in the body, building muscle and facilitating recovery after injury. For the Herpes Simplex Virus 1 and 2, both cold sores and genital herpes, lysine has been clinically proven to reduce the duration and severity of these infections, as well as preventing the virus from spreading.
There are many conflicting reports on this particular supplement topic, however from our own experience with these supplements we’ve found that arginine and lysine are not as highly effective when used together, but rather l-arginine, l-citrulline and l-carnitine seem to be the driving force behind the heart healthy results we wish to provide. For example, the lysine acetylation of histones plays an essential role in regulation of gene expression.

The acetylation state of a protein not only modify its activity, but also crosstalks with phosphorylation, methylation, ubiquitination, sumoylation, and others for dynamic control of cellular signaling.
With the heart healthy benefits of L-Arginine, L-Citrulline and Red Wine Extract, combined with the metabolism boosting and muscle building benefits of L-Carnitine, we have found that lysine is unnecessary in our formula. It should never be taken without speaking to a physician first as it might interact poorly with medications that you could be taking. Beyond histones, a wide range of non-histone proteins can also be lysine acetylated, and involved in a variety of biological processes, such as transcription regulation, DNA replication, cellular signaling, stress response, and so on.
Lysine has been shown to increase bad cholesterol levels, leading to poor blood circulation, which is the exact opposite of what we aim to do with our heart healthy supplement. Aberrant lysine acetylation and deacetylation is associated with various diseases and cancers.
In particular, acetylation was demonstrated to be implicated in cellular metabolism and aging.

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