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As NaturallyCurly's resident UK contributor, I've searched high and low for the most trusted salons on the other side of the pond. Believe me or not, it actually took four years to find a washday routine to accentuate the beauty of my curls! A Flexible Spending Account (FSA) allows consumers to deduct pre-tax dollars from their paychecks and deposit those funds in employer-sponsored accounts to pay for medical expenses. Fel-O-Lysine is a L-Lysine supplement in powder form for cats used as an aid in the treatment of feline herpes virus.
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Prototype 7 is a patented transdermal used during exercise to help hold nutrients at the target muscle site longer, thus enhancing muscular growth and reducing muscle breakdown. Induce powerful vasodilation and pump when applied directly to the target muscle group you are training.
Rosemary essential oil is used for mental strain, dullness, lethargy or exhaustion.  Rosemary essential oil crosses the blood brain barrier after massage and inhalation faster than an oral supplement can. Rosemary oil is a very powerful stimulant of the brain and central nervous system (CNS) making it a very effective tool in helping to clear the mind and focus on the task at hand; increasing mental awareness and activating the mind muscle connection. Rosemary oil also has the unique ability of working transdermal and via inhalation to access the brain and CNS without adding burden to the adrenal gland and stimulating excessive catabolic cortisol release. The combination of rosemary oil with peppermint oil has a synergistic effect and the combination shows a more profound action than when used alone.
Rosemary oil also enhances the parasympathetic nervous system which regulates by inhibiting acetylcholinesterase, an acetylcholine degradation enzyme which results in an accumulation of acetylcholine in nerve synapses; focus, concentration span and growth and recovery. Transdermal absorption of rosemary oil activates the Autonomic nervous system (ANS); enhancing both parasympathetic and sympathetic nerve activity. ATP Science recommends the following: after you warm up the target muscle group apply the Prototype 8 to finish off the session with a full on pump, sweat and muscle burn. Everyone uses it a little bit differently so work out what is the best way for you and your style of training. Prototype 8 is a site specific transdermal vasodilating serum formulated to deliver phytoecdysteroids into local tissues to enhance healing, recovery and muscle hypertrophy. Novas TM – Aqua, Natural Emulsifying wax ( Cetearyl alcohol and Ceteareth-20), Ethyl-alcohol, Rosmarinus officinalis essential oil, 20-hydroxyecdysterone derived from Cyanotis arachnoidea extract, L-Arginine Hydrochloride, Sorbitol, , Aloe Barbadensis Leaf Juice, Stearic acid, propylene glycol, Cyclopentasiloxane, Tocopheryl acetate (Vitamin E), Piper nigrum essential oil, Mentha piperita essential oil, Phenoxyethanol, Caprylyl Glycol, Disodium EDTA.
Apply prototype 8 to the muscle groups post training with post workout nutrition to enhance delivery of macro and micro nutrients to the muscles trained and enhance recovery, repair and hypertrophy. Certain sports such as CrossFit, MMA, Boxing, Rugby codes, cycling and athletics can find excessive vasodilation inhibitory to performance.  Using Prototype8 immediately post event and training is ideal.
Apply Prototype 8 to the trained muscle group the morning after to help clear metabolic waste and deliver micro and macro nutrients to speed healing, recovery and hypertrophy. Vasodilating ingredients will induce vasodilation immediately upon interaction with enzyme systems and receptors. You must use excessively high doses of oral vasodilators to achieve peripheral vasodilation into the trained muscle groups as the ingredients will be used up dilating blood vessels in the gut, liver and brain first.
Transdermal technology is capable of delivering vasodilators in a sustained release system allowing for immediate delivery of fast acting vasodilators to local vasculature followed by a gradual trickle to maintain local vasodilation for a longer period of time.
Phytoecdysteroids are natural compounds with powerful anabolic effects comparable to androgens and anabolic steroids. Transdermal delivery is; using creams, serums, patches and lotions applied directly to the skin to deliver active ingredients into either the peripheral circulation or to a specific distal site.
Transdermal delivery means you can bypass the pitfalls associated with oral delivery such as bad taste or large serving sizes of capsules and powders; gut upset and other intolerances that lead to poor compliance and ultimately poor results.
Transdermal delivery also means that you can increase the bioavailability of certain ingredients as you can bypass the digestive process and first pass metabolism by the liver that can reduce the bioavailability of ingested ingredients by breaking it down and eliminating the actives before they get into the systemic circulation to deliver to distal sites. Direct delivery to target site can also overcome poor delivery due to poor circulation in problem areas.
Transdermal absorption of active ingredients is mostly limited by the skin’s outermost layer called the stratum corneum, which is 10 to 20 µm thick (Fig. The stratum corneum resembles a brick wall under a microscope; with non-living skin cells making up the bricks and oily watery layers that make up the mortar. Natural and synthetic chemicals with molecular weights of 100 to 800 and adequate fat and water solubility can permeate through the stratum corneum bricks and mortar and get inside your body.
Underneath the stratum corneum barrier is the viable epidermis, which measures 50 to 100 µm and does not have a blood supply; but below this layer is the dermis, which is 1–2 mm thick and contains a rich blood supply in the form of a bed of capillaries that allows for systemic absorption of the active ingredients. The dermis is a largely fibrous layer that provides skin’s mechanical support, as well as the skin’s blood supply and anchoring for the sweat gland and hair follicles. Penetration enhancers can increase skin permeability and provide an added driving force for transport by increasing drug partitioning into the skin. Hundreds of different chemical enhancers have been studied, including off-the-shelf compounds and others specifically designed and synthesized for this purpose, such as compounds isolated from Piper nigrum (Black pepper), Mentha arvensis (peppermint), Mentha piperita (peppermint), Disodium EDTA, Azone (1-dodecylazacycloheptan-2-one), Dimethyl Isosorbide (DMI) and SEPA (2-n-nonyl-1,3dioxolane). There is an abundance of research going into the development of new chemical penetration enhancers.
Nitric Oxide (NO) induced vasodilation is a significant tool in the arsenal for stimulating muscle hypertrophy.
We understand the simple concept of enhancing blood flow to the target muscle group via NO vasodilation to deliver nutrients and remove waste; but is there more to it?
Is it a temporary effect to make your muscles feel larger and make you feel as though you are making gains and your training session was worthwhile or is it actually stimulating muscle growth? Satellite cells are responsible for making muscle cells (myoblasts) for muscle growth (hypertrophy) and repair. When the muscle bundle is fully pumped, swollen and stretched through exercise or injury; satellite cells are activated to enter the cell cycle and induce muscle growth and repair.
This whole series of events begins with calcium influx and calcium-calmodulin formation and the NO comes after this. This means that muscle damage and pump induced stretching of the muscle bundle allows calcium from outside the muscle cell to rush in and trigger a series of events that activate satellite cells to stimulate muscle hypertrophy. Phytoecdysteroids do not bind to the cytosolic steroid receptors, instead, they influence signal transduction pathways, like the anabolic steroids, possibly via membrane bound receptors.
20-Hydroxyecdysone (20E) is an ecdysteroid hormone that has anabolic effects in vertebrates, i.e. 20-hydroxyecdysone has androgen-like anabolic action but numerous studies have confirmed that it does not have hormonal effects.

This means it works as well as androgens and hormonal manipulation to enhance anabolism without the side effects of hormonal manipulation.
The anabolic effect of ecdysteroids is connected with the acceleration of translocation processes instead of the induction of new RNA synthesis; meaning ecdysteroids are not likely to act as the classical steroids, via cytoplasmic receptor and regulation of gene transcriptional activity. The anabolic effects of 20-hydroxyecdysone and turkesterone are nearly equal to that of Nerobol®. Methandrostenolone produced anabolic effects only after constant training, but 20-hydroxyecdysone improved the physical ability of the mice both with and without this preconditioning training. Ecdysteroids affect the metabolic processes of protein synthesis and energy consumption in cells and are responsible for recovery from muscular tiredness during intensive training. Phytoecdysteroids appear to be a deserved substitute for popular, but forbidden preparations such as the anabolic-androgenic products: Nerobol®, Durobolan® or Proviron®, used in speed and power sports. Phytoecdysteroids produce a range of effects in mammals, including increasing growth and physical performance. When skeletal muscle is stretched or injured, satellite cells are activated to enter the cell cycle.
Delivering phytoecdysteroids with arginine during training can amplify the calcium influx and NO production along with the mechanical stimulus of swelling, inflammation and stretch of the muscle bundle to mimic injury and create exaggerated healing response. This signalling pathway is a cascade of events including calcium influx for calcium-calmodulin formation and nitric oxide (NO) radical production by NO synthase. The influx of calcium ions and their binding to calmodulin are thought to be involved in the segment of the activation pathway between sensing the mechanical stimulus and synthesis of the NO radicals. Calcium-calmodulin formation is required for NOS activation that produces the NO radical from L- arginine and which subsequently releases growth factors.
Triggering the activation of quiescent satellite cells, is initiated by mechanical (training) or chemical stimuli (arginine and phytoecdysteroids) enables satellite cells to migrate and enter the cell proliferation cycle. Animal studies have shown 112 to 116% increase in growth of lean muscle mass compared to controls. Intra and post workout nutrition is extremely important to maximise gains from topical ecdysterones.
The anabolic affects and increase in muscle protein synthesis can explain the enhanced performance seen in animal studies that improved swimming time to exhaustion after using ecdysterones. Increases energy expenditure and stimulates glucose oxidation by muscle for fuel at the expense of lipogenesis and storage. Ecdysterones enhance utilization of amino acid and protein supplementation and enhance protein synthesis.
Using the Prototype 8 cream prior to last set designed to induce maximal blood flow to the trained muscle and immediately using a post workout supplement after that supplies 10g protein for every 40kg body weight will potentiate protein utilization.
The protein synthesis and anabolic effects are comparable to Dianabol, Steranabol and Deca- Durabolin 15. Phytoecdysteroids work synergistically with arginine by inhibition of L-arginine degradation by arginase resulting in up-regulation of Ca(2+)-dependent constitutive NO synthesis by eNOS. Phytoecdysteroids are rapidly detoxified by the liver and eliminated via faecal and urination pathways.
Alternatively slow delivery systems such as topical application for transdermal delivery can maintain higher local levels of active ingredients into the target muscle tissue.
Using ecdysteroids in combination with topical arginine in an isolated area will allow for maximal exposure to muscle tissue. When this is combined with particular training strategies designed for maximal vasodilation and engorgement of target muscle with blood then it is possible to maximise the anabolic gains from the ecdysterones. Interestingly the topical application of arginine has a longer lasting effect for maintaining local vasodilation due to the delayed release of the NO precursor from the skin surface to the local vasculature.
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Supports immune system function, collagen formation, tissue repair, antioxidant activity and antibody lymphocyte production.
Due to its high lipophilicity; the fragrance molecule easily penetrate the blood brain barrier and enter to the brain following inhalation or massage.
Rosemary oil can activate the sympathetic nervous system to induce alertness and energetic arousal like caffeine or amphetamines and amphetamine-like compounds can but has actually been shown to decrease cortisol release.
Transdermal vasodilators have a more localized effect specifically opening up the blood vessels at the area of application.
Stimulating the sympathetic nervous system (SNS) makes it possible to maintain adequate blood pressure in the dilated arteries to have enhanced oxygenation. Prototype 8 is a very powerful tool and needs to be incorporated into training a certain way. Please be aware that excessive muscle pump and vasodilation can be inhibitory to your workout and reduce amount of reps and sets achievable due to excessive muscle engorgement. This will potentiate the “mind-muscle connection” and aid the delivery of ingested nutrients to the muscles groups you are planning on training. Phytoecdysteroids have poor bioavailablity when taken orally and used intravenously.  Combining the phytoecdysteroids with sustained release vasodilators and used in conjunction with training for maximal muscle pump will maximise the exposure time of muscle tissue to these anabolic compounds. Chemicals with a small enough particle size and the right amount of oil and water solubility can penetrate this barrier by winding between the bricks through the mortar. Phytoecdysterones have a molecular weight of approximately 480, forskolin 410, progesterone 314, testosterone 288, chrysin 255, arginine 210, ibuprofen 206 and caffeine 195.
The sweat gland and hair follicles provide another transport pathway to deliver active ingredients past the stratum corneum to the microcirculation of the dermis layer and then into the local fatty layers and systemic circulation. Most effective penetration enhancers disrupt the highly ordered bilayer structures of the intracellular lipids found in stratum corneum to disorganize molecular packing or by extracting lipids using solvents and surfactants to create lipid packing defects of nanometer dimensions. This is just a natural progression of the pharmaceutical industry increasing their IP portfolio to include the excipients and all aspects of pharmaceutical drug delivery; but this does not mean that synthetic chemicals are more effective than the original natural product that has been used traditionally but was unable to patent in its natural form. Research into the driving forces behind muscle growth is fascinating and new discoveries are being published all the time.
A satellite cell is a kind of myogenic stem cells, which plays an important role in muscle development and injury repair.
And how can we use supplements, botanicals and training techniques to trigger muscle hypertrophy?
This signalling pathway is a cascade of events initiated by calcium influx that triggers nitric oxide (NO) production, and other growth factors from the extracellular matrix to activate the satellite cells for muscle hypertrophy.

Supplementing with substances to enhance and support NO formation and subsequent vasodilation are essential for this process but it is the calcium influx from the pump and stretch that triggers this next step. Muscle cells respond to the muscle pump and stretch in the muscle bundle by gating cations; this would result in local depolarization of the plasma membrane that allow a significant amount of calcium ions to permeate the cell and lead to calcium-calmodulin formation.
Furthermore blocking calcium influx has shown to inhibit satellite cell activation and muscle growth. Mstn is produced predominantly in skeletal muscle with lower levels of expression observed in white adipose tissue, heart and mammary gland. Plants comprise rich sources of phytoecdysteroids in high concentration and with broad structural diversity. The application of phytoecdysteroids is a promising alternative to the use of anabolic-androgenic steroids because of the apparent lack of adverse effects.
Methandrostenolone stimulated the biosynthesis of myofibrillar proteins in the musculus soleus, but not in the musculus extensor digitorum longus, while 20-hydroxyecdysone increased the amount of myofibrillar proteins in both muscles.
In skeletal muscle cells, phytoecdysteroids increase protein synthesis elicited by a rapid elevation in intracellular calcium, followed by sustained Akt activation and increased protein synthesis.
With this cascade of events amplified while in the absence of a catabolic injury; it is possible to induce muscle hypertrophy. The release of certain growth factors is completely dependent on nitric oxide (NO) radical synthesis by NO synthases (NOS) from L-arginine of the substrate.
Studies show 20g protein for 80kg athlete is adequate to supply amino acids for muscle growth. Inhibition of arginase means the arginine conversion to ornithine and urea is reduced and its conversion to the vasodilating NO is enhanced. Oral ecdysteroids have a poor bioavailability as the liver quickly eliminates via bile and back into the gastrointestinal tract after digestion and absorption. Elimination takes place in the liver and therefore strategies to hold the active ecdysteroids in the target muscle group for as long as possible to reduce or delay the exposure of the active compounds to hepatocytes and subsequent elimination will increase the exposure time to the specific target muscle group. The purpose of these studies was to determine how rapidly vasodilation to arginine or constriction to lysine could be achieved.
This product is a water soluble powder formula used as an aid in the treatment of feline herpes virus and its associated respiratory and ocular symptoms and as a general L-Lysine supplement. Simultaneously the rosemary oil inhibits acetylcholine esterase allowing acetylcholine to accumulate in nerve synapses for prolonged muscle contraction. There are a variety of active components of natural plants such as black pepper and peppermint essential oils that have been isolated, copied, manipulated and patented as synthetic chemical penetration enhancers. Through proliferation, differentiation and fusion of muscle fibers; satellite cells make new myonuclear, leading to the hypertrophy of skeletal muscle and fiber type transformation.
The satellite cell niche is on the surface of the myofibre, beneath the surrounding basal lamina, as indicated. What this means is that using NO donors and vasodilators and focusing purely on supplements for NO-induced vasodilation without using phytoecdysteroids and training techniques to induce calcium influx than you won’t be activating satellite cells maximally.
Analysis has revealed that Mstn is a profound negative regulator of muscle growth; while inactivation or mutation of the Mstn gene leads to increased skeletal muscle mass, enhanced myoblast proliferation, differentiation and improved skeletal muscle regeneration. Phytoecdysteroids exert numerous effects in vertebrates that are similar to those of vertebrate hormonal steroids, and they may serve as effective anabolic, hepatoprotective, immunoprotective, antioxidant and hypoglycemic agents. 20E affects the size (cross-sectional area, CSA) of the different fiber types in a muscle-specific manner. Production of NO is a key signal responsible for satellite cell hypertrophy and detachment from the adjacent fiber. A 20g dose of whey protein is sufficient for the maximal stimulation of postabsorptive rates of myofibrillar muscle protein synthesis in rested and exercised muscle of ~80-kg resistance-trained, young men. Ecdysterones elicit a rapid elevation in intracellular calcium, followed by sustained Akt activation triggering increased protein synthesis.
The active half-life of ecdysteroids varies according to the type of ecdysteroid used, the animal selected for the study and the mode of delivery.
On the right side of Panel A, the ratio of the post-arginine resting [NO] to that at control prior to arginine exposure is shown. The Thomas Labs Fel-O-Lysine is very easy to mix with their canned food and the kitties just gobble it down without hesitation. Make sure you re-apply after your workout before you consume your post-workout meal or shake.
Recent research has shown that the surfactants and compounds from Piper nigrum (black pepper) and Mentha arvensis (peppermint) essential oils succeed for delivery of active ingredients where individual chemical enhancers have generally failed.
It is also shows that enhancing calcium influx as part of this tissue damage and stretch response will maximise satellite cell activation and muscle growth and repair. Besides the fiber size, 20E also increased the myonuclear number in the fibers of normal and regenerating muscles, via activation of satellite cells and inhibition of myostatin. The half-life ranges from 8 minutes oral dose in a rat to up to 9 hours for 20- hydroxyecdysoid in one male human.  Suffice to say that it would take large doses many times daily to maintain a steady blood level of active blood levels.
Panel B presents the time to stably increased blood flow for topical arginine concentrations of 200–1200 µM.
It is great to be able to give them something to help their immune system without having to fight them. Drug penetration across the stratum corneum is limited primarily by the lipids organized in bilayer structures (L) that fill the intercellular spaces between corneocytes (C). DAPI counterstaining (C) reveals both the nucleus of the same satellite cell (arrow) and the myonuclei of the myofibre. The flow responses represent combined resistance responses of small arteries in the mesentery as well as the microvasculature. The arrow indicates a Pax8-expressing satellite cell located on the surface of a myofibre; the arrowhead highlights a myonucleus.
Panels C and D are representative NO responses to the wash in and wash out of 400 µM L-arginine added to the bath. The overall data indicate a rapid rise in [NO] with arginine exposure, but a much slower decay with washout to near the original resting [NO].

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