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If the above diagnoses are inconclusive or if a treatment regimen has already been started, a biopsy of the affected skin (i.e.
Spray tub and bathroom floor with disinfectant after each use to help prevent reinfection and infection of other household members.
Wash feet, particularly between the toes, with soap and dry thoroughly after bathing or showering. If you have experienced an infection previously, you may want to treat your feet and shoes with over-the-counter drugs. Dry feet well after showering, paying particular attention to the web space between the toes.
Try to limit the amount that your feet sweat by wearing open-toed shoes or well-ventilated shoes, such as lightweight mesh running shoes.
After any physical activity shower with a soap that has both an antibacterial and anti-fungal agent in it. Rat-bite fever is caused by either Streptobacillus moniliformis or Spirillum minus inoculated by the bite of a rat. The incubation period is short; the disease has an abrupt onset characterized by fevers and toxaemia.
Borreliosis is transmitted from rodents or deer by ticks particularly in open forest habitat (e.g.


The cat is the definitive host of Toxoplasma gondii but the organism infects a wide range of animals, including sheep, cattle and humans.
Dermatophytes that are natural pathogens of animals can spread to the human population by direct contact. Two species of parasite are responsible for human hydatid disease: Echinococcus granulosus and Echinococcus multilocularis. Echinococcus multilocularis is found in foxes, wolves and dogs; rodents act as the intermediate hosts.
Cysts act as space-occupying lesions in the liver, lungs, abdominal cavity or central nervous system.
Herpes simiae, a monkey pathogen, which causes severe encephalitis, or avian ‘flu, both of which are associated with high mortality). The regional lymph glands draining the site of the bite become greatly enlarged (buboes) and septicaemia is accompanied by generalized haemorrhage. Infection is acquired by ingestion of oocysts from infected cat faeces or from tissue cysts in infected meat (e.g. Albenda-zole is given to kill the germinal layer of the cyst and praziquantel to reduce the viability of protoscolices. Pneumonic plague is a rapidly fatal pneumonitis that can be transmitted by the respiratory route.


Human ingestion occurs when food is contaminated by the soil or when personal hygiene is poor (e.g.
Puncture, aspiration, injection of chemicals and re-aspiration (PAIR) is seen as an alternative to surgical excision. The organism is transmitted both between rats and to humans by the rat flea, Xenopsylla cheopis. The larval stages hatch in the intestine, invade the host and migrate to the liver and lungs. They are unable to develop into adults but migrate throughout the body causing fever, hepatosplenomegaly, lymphadenopathy and wheeze. If the larva migrates into the eye, sight may be permanently damaged by the local inflammatory response of the retina. The disease is usually self-limiting but, if symptoms are severe, treatment with albendazole may be beneficial.
Ocular lesions should first be treated with steroids to diminish the inflammatory response; the role of antihelmin-thic treatment is less certain.



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