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Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes. T cells, a type of white blood cells, generate immune responses to pathogens and are important in controlling infections. Wald and her team presented the initial findings of the first-in-human clinical trial of the novel GEN-003 T cell vaccine Sept.
Genocea plans to move into Phase 2 of this trial in 2014 to further evaluate GEN 003’s safety and effectiveness in a larger group of patients.
At unpredictable times in those carrying the infection, the herpes virus will come out of hiding and  surface on the genitals, sometimes producing blisters and discomfort, and sometimes arising without any noticeable symptoms.  This surfacing is called viral shedding.
The results also demonstrated that immunization with GEN-003 is associated with activation of T cell immunity.
The first-in-human clinical trial was not designed to test whether GEN-003 lessens symptoms or lowers how often a breakout occurs. Genocea developed the proprietary platform ATLAS, which can identify protective T cell antigens in people exposed to a pathogen.
The vaccine contains, among other components, a proprietary adjuvant, trademarked Matrix-M.
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Justin Caba Justin Caba is a reporter for Medical Daily focusing on nutrition, fitness, and all things athletic. According to a new study published in the Advance Online Publication of Nature, Yale researchers are presently busy developing a new vaccine that could potentially keep people from becoming infected with HSV (herpes simplex virus, i.e.
The main drive behind their endeavor is represented by the fact that, although cases of genital herpes translate into noteworthy health problems and even death on quite a regular basis, proper treatment and effective means of immunization are still lacking. Thanks to funding provided by the US National Institutes of Health, this team of specialists was able to perform laboratory experiments on mice. The official website for the Yale University informs us that it was these experiments which lead them to the conclusion that activated T cells (i.e. Apparently, once they are set in place, these T cells provide protection against HSV and keep it from spreading as it normally would. Up until now, T cells have not been harnessed in organs such as intestines, central nervous system, lung airways and the vagina, seeing how they all restricted their access. The researchers speculate that this vaccination model could also be efficient went it comes to providing some levels of protection against other sexually transmitted infections such as HIV-1.
After decades of stagnancy in the herpes therapeutics space, a real neck-and-neck race is emerging among three biotechs in the immunotherapy space: Genocea and Agenus, both based in Massachusetts, San Diego’s Vical are speeding ahead in developing a herpes vaccine. On top of that, Australian biotech Admedus just announced positive early clinical results for its own genital herpes vaccine.
Now, standard vaccines usually corral the immune system’s B cells, siccing them on invaders and successfully drawing out antibody responses.
Genocea may have a few toes ahead in the race, but the triumvirate’s all in the Phase II vicinity and eliciting positive results. Stay tuned for a closer look at what’s going on with the herpes vaccine, with insights from stakeholders and CEOs. In this video, learn why people are starting to realize that telemedicine is simply another form of medicine. Providers are realizing that patients are customers, and healthcare services have to be tailored to their diverse needs and circumstances.
Early clinical trials in the United States have found the vaccine can prevent infection in three out of four women. An estimated 100m people around the world are infected with what is known as herpes simplex virus type 2.


The virus can cause painful itching and sores that in some cases reappear years after infection. However, many people do not have symptoms and can therefore pass on the infection without knowing it. A vaccine could be of real benefit to the thousands of infants born every year with the virus. Dr Lawrence Stanberry and colleagues at the University of Texas Medical Branch tested the vaccine on 978 women and 1,736 men whose partners had genital herpes.
Each received three injections containing the vaccine or injections containing a placebo over the course of six months.
The researchers found that the vaccine did not work well in women who had been infected with a related virus - herpes simplex virus 1. GlaxoSmithKline is now recruiting 7,550 women between the ages of 18 and 30 across the US for final stage clinical trials. The UK Herpes Viruses Association said most new cases of genital herpes are actually caused by herpes simplex virus 1 - the virus that causes cold sores. Marian Nicholson, its director, said there was a need to tackle the stigma around the virus.
This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003. David Koelle’s lab in the Division of Allergy and Infectious Diseases, Department of Medicine.
T cell vaccine research is trying to find safe, effective ways to spur this protective reaction. 12 at a session of the Interscience Conference on Antimicrobials Agents and Chemotherapy in Denver. The infection can provoke recurring episodes of painful genital sores.  An estimated 50 million to 60 million Americans are affected.
In those receiving the vaccine candidate, T cell immune responses increased more than 20 times to one vaccine antigen and more than 10 times to another antigen.  The vaccine candidate also increased neutralizing antibodies to the herpes simplex 2 by five times greater than baseline amounts. However, an exploratory analysis suggested that the interval between the first immunization with GEN-003 and the next recurrence of genital herpes might be longer in those receiving the actual candidate vaccine, rather than the placebo injection. Wald is enrolling women infected with herpes simplex virus 2 in a study to see whether the drug tenofovir, given orally or as a vaginal gel, reduces genital shedding of the virus. All rights reserved.Medical Daily is for informational purposes and should not be considered medical advice, diagnosis or treatment recommendation.
And Oregon’s Tomegavax is using Gates-funded research to forge its own path in developing its own vaccine. Big pharma dabbled in developing a genital herpes vaccine, but GlaxoSmithKline was particularly noteworthy for its epic flop – compared to controls, it actually caused even worse outbreaks in the women studied in a huge Phase III study.
However, half of those infants who contract the virus die unless they receive powerful antiviral drugs. Genocea, located near Boston, is a clinical-stage biopharmaceutical company for the discovery and development of T cell vaccines to prevent and treat infectious diseases. Viral shedding is a marker both of the risk of recurrence and the transmission of infection. The adjuvant has a product that, in previous clinical studies, has been shown to stimulate B and T cell immune responses.
Reducing the frequency of viral shedding is the first step to showing that a drug can reduce outbreaks or, potentially, sexual transmission to partners. What the newer methods of vaccination are doing is mobilizing the T cell response to reduce the viral load.


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Tenofovir has been shown in some studies to reduce the risk of acquiring HIV, and in some studies there was also a reduction in the frequency of HSV-2 acquisition, but this is the first time that it is being tested as a drug specifically for HSV-2. Under the HoodBehavior, Neuroscience & Your Brain Doctors Misdiagnose Comatose Patient As Brain Dead, Refuse To Treat Her A father recently sued a hospital and won, proving that his daughter was not brain dead — a diagnosis the hospital wrongfully gave. Bohle Maschinen + Verfahren GmbH LabWare Linkam Scientific Instruments Limited MKS Umetrics Molins Technologies Multicore Dynamics Ltd Nanosurf New England Biolabs, Inc. The HillHealthcare, Policy & Governance Oklahoma Bill To Jail Abortion Doctors Heads To Governor An Oklahoma bill that could send any doctor who performs an abortion to jail headed to the governor on Thursday, with opponents saying the measure is unconstitutional and promising a legal battle against the cash-strapped state if it is approved.
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The National Institute of Allergy and Infectious Diseases (NIAID) has started clinical trials, which focus on an investigational drug that may prevent future herpes diagnoses.According to the Centers for Disease Control and Prevention, 776,000 people in the United States are diagnosed with a new herpes infection each year.
HSV 2 infections affect one out of every five women over the age of 14 compared to one out of every nine men.Genital herpes can be spread from person to person through anal, vaginal, or oral sex when HSV 1 or HSV 2 escapes from soars in the groin area. People contract genital herpes through the herpes simplex viruses type 1 (HSV-1) or type 2 (HSV-2). Considering signs and symptoms of herpes can go unnoticed or can be mistaken for another skin condition, HSV 2 carriers can be unaware of their condition. Symptoms can appear in the form of blisters on the sufferer’s mouth, rectum, or genital area that break and leave painful sores that may not clear up for weeks.
People with a compromised immune system are especially at risk for developing genital herpes.Researchers working on this genital herpes vaccine recruited 156 patients who had tested positive for HSV 2. When HSV infects the body, it immediately makes its way to nerve cells where it remains for the patient’s entire life. Throughout the study each participant was asked to record instances of genital herpes signs and symptoms. Knipe and his colleagues from NIAID will divide the study’s participants into three groups, including one that has been infected with HSV-2 and HSV-1 or just HSV-2, a second that has been infected with only HSV-1, and a third that has no history of being infected with HSV-1 or HSV-2. Although the use of latex condoms can reduce a person’s chance of being infected by HSV 2, signs and symptoms can still occur in the area of the body covered by the condom. Researchers have removed two key proteins from the vaccine virus to prevent the spread of genital herpes. Blood samples will be taken from each participant at the end of the study to determine if HSV529 effectively stimulates the immune system to fight off the herpes virus.



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Comments
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  2. TT 13.06.2014 at 17:32:34
    Infects greater than three-quarters of a million.