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Ketamine was first synthesized in 1962 in an attempt to find a safer anaesthetic alternative to PCP, which was more likely to cause hallucinations and seizures.
Given that it suppresses breathing much less so than most other available anaesthetics, ketamine is still used in human medicine as a first-choice anaesthetic for victims with unknown medical history (e.g. In veterinary medicine, ketamine is often used for its anaesthetic and analgesic effects on cats, dogs, rabbits, rats, and other small animals. The effect of Ketamine as a depressant on the respiratory and circulatory systems is less than that of other anaesthetics. Postherpetic neuralgia: Localized pain in the area of involvement of shingles that persists beyond one month. Neuralgia, postherpetic: Localized pain in the area of involvement of shingles that persists beyond one month. Filter: All types Articles Slideshows Videos Sort: Most relevant Most popular Most recent No articles available No slideshows available No videos available Natural Cures for a Bladder Infection in Dogs Natural Cures for Psoriasis Natural cures for sinus problems Natural Cures for Cluster Headaches Natural cures for rising creatine levels How to treat stomach ulcers with natural remedies Natural cures for hiatal hernia Skin Problems After Shingles Natural Cures for Enlarged Thyroid Natural cures for cancer in dogs Natural acid reflux remedies Sinus Polyps Natural Cures Natural remedies for toothaches Natural Cures for Sinus Infections Natural cures to stop menstrual bleeding Natural cures for toenail fungus Homeopathic treatment options for shingles Natural Cures for Gum Disease Natural Treatments for Peripheral Neuropathy Natural Cures for Cold Sores for Infants Natural Heartburn Cures What does skin shingles look like?
Post-herpetic neuralgia (PHN) is the medical term for post-shingles pain, or pain after shingles. It manifests as local or peripheral pain with symptoms often described as burning, stabbing, or shooting pain, and also allodynia, and hyperalgesia.
Many patients live with neuropathic pain conditions such as PHN for a long time before they are correctly diagnosed and receive appropriate treatment. The symptoms of neuropathic pain may vary, and due to its complex pathophysiology, PHN is often difficult to treat.
PHN presents differently from patient to patient and there are a number of elements to an accurate diagnosis. In addition, gaining an accurate description from the patient of the nature of the pain can also prove useful. A physical examination and tests for positive or negative sensory signs, allodynia, and hyperalgesia, can be carried out. As PHN is a type of Localized Neuropathic Pain (LNP), the LNP Screening Tool, which was developed by international experts, can help to support doctors and patients in getting an early diagnosis leading to an adequate treatment30. Different sensory symptoms and types of pain may exist in PHN and these can vary in respect of location, intensity, duration and quality. Therefore, asking the patient about their pain can provide useful indicators to aid diagnosis.
Asking your patient to describe the type of pain they have been experiencing can also prove useful, as words such 'shooting', 'stabbing' or 'burning' may indicate PHN. Systemic therapies include anticonvulsants, tricyclic antidepressants (TCAs), serotonin noradrenaline reuptake inhibitors (SNRIs) and opioids which are associated with a number of systemic side effects. With these treatment options, physicians and patients often struggle to find a balance between efficacious dosing and dose-limiting side effects.
Versatis® is a topical treatment which offers proven efficacy, excellent tolerability with a low rate of systemic side effects and is easy for patients to use - leading to high levels of patient satisfaction and quality of life improvements. The drug was first used on American soldiers during the Vietnam War, but is often avoided now because it can cause unpleasant out-of-body experiences. The drug was used in psychiatric and other academic research through the 1970s, culminating in 1978 with the publishing of John Lilly's The Scientist, a book documenting the author's ketamine, LSD, and isolation tank experiments. Veterinarians often use ketamine with sedative drugs to produce balanced anaesthesia and analgesia, and as a constant rate infusion to help prevent pain wind-up. It has the added benefit of counter-acting spinal sensitization or wind-up phenomena experienced with chronic pain. When used at anaesthetic doses, it will sometimes stimulate rather than depress the circulatory system.


They state that postherpetic neuralgia (PHN) is the most common complication of herpes zoster (shingles), causing pain that often lasts for years.
The most common complication of shingles is postherpetic neuralgia. This occurs when the pain associated with shingles persists beyond one month, even after the rash is gone.
This condition is often treated with pain medications that have side effects that are intolerable to some people. Shingles (herpes zoster infection) is a disease affecting the nerves that causes pain and blisters during the outbreak. Post-shingles pain may be difficult to diagnose, especially in patients, who develop herpes zoster infection without typical rash. 2,9,10 Therefore, without a clear diagnosis, patients may undergo 'trial and error' treatments or endure a step-wise treatment approach over months or even years.
In particular, establishing if there has been an episode of shingles recently, and if so, where was this located? The screening tool is presented as a DIN A6 pocket card with four decision making questions about patient`s history, pain distribution, testing of symptoms, and the location and size of the painful area on the patient`s body. There are a number of formalised scales that can be used to describe and measure the intensity of pain, for instance where 0 represents 'no pain', through to 10 which represents 'pain as bad as you can imagine'. Pharmacologically it is very similar to other dissociative anesthetics such as tiletamine and phencyclidine (PCP).
The incidence of recreational ketamine use increased through the end of the century, especially in the context of raves and other parties. There is ongoing research into the drug's usefulness in pain therapy and for the treatment of alcoholism and heroin addiction.
Ketamine is used to manage pain among horses and other large animals, though it has less effect on bovines. At these doses, the psychotropic side effects are less apparent and well managed with benzodiazepines.
It is sometimes possible to perform ketamine anaesthesia without protective measures to the airways. In the United States, gabapentin and topical lidocaine are the only drugs officially indicated for use in treating PHN.
This occurs when the pain associated with shingles persists beyond one month, even after the rash is gone. The pain can be severe and debilitating and occurs primarily in persons over the age of 50.
The condition can be treated with natural remedies that relieve the pain of postherpetic neuralgia.
After the shingles outbreak is over, significant pain occurs or persists three months or more after the healing of herpes zoster lesions or rash. 16,17 The pain associated with PHN may be intermittent and the patient may not be aware that pain can occur after the shingles rash has healed. Patients can then be asked to rate their pain with a number that best equates to the pain they have experienced over the last 24 hours.
The increase in illicit use prompted ketamine's placement in Schedule III of the United States Controlled Substance Act in August 1999. Ketamine is also a potent analgesic and can be used in sub-anaesthetic doses to relieve acute pain; however, its psychotropic properties must be taken into account. Amitriptyline, nortriptyline, opioids and capsaicin also have been studied for this use in randomized, placebo-controlled trials.
The pain can be severe and debilitating and occurs primarily in persons over the age of 50.


There is some evidence that treating shingles with steroids and antiviral agents can reduce the duration and occurrence of postherpetic neuralgia.
About us Use of this site constitutes acceptance of the Terms of use, Cookie policy, and Privacy policy of eHow. An accurate evaluation of pain therefore has a critical role to play in the identification and treatment of PHN. Patients have reported going into other worlds or seeing God while anaesthetized, and these unwanted psychological side-effects have marginalized the use of ketamine in human medicine.
The authors believe that the use of a topical ketamine gel in the treatment of PHN shows promise.
There is some evidence that treating shingles with steroids and antiviral agents can reduce the duration and occurrence of postherpetic neuralgia. Between 1994 and 2002 they studied the use of topical ketamine gel in 23 patients (13 men and 10 women). The product can be found in natural oral medications and topical creams that relieve the pain of this nerve condition.
The patients applied a thin film two orthree times daily to the areas where their PHN pain was most severe. When capsaicin is applied to the skin, it stops a chemical in the nerves that is responsible for the transmission of pain. For 16 of the patients, ketamine was either used alone or added to an already-established PHN drug treatment regimen. Acupuncture and electric nerve stimulation through the skin can be helpful for some patients.
These creams are available without a doctor's prescription and are made from natural materials. For the other 7 patients, topical ketamine therapy and other drugs were started at the same time. The cayenne pepper also has an ingredient called salicylates, which act on the body in the same way as aspirin. The only side effect, skin irritation at the ketamine application site, was noted in 2 patients who did not respond to topical ketamine therapy; the skin irritation resolved once ketamine therapy was stopped. The authors believe the results of their research suggest that formal placebo-controlled trials of topical ketamine to treat PHN are warranted.
Of particular interest to compounding pharmacists is the authors' detailed description of their preparation of the topical ketamine gel.
A poultice that is made with ginger syrup and placed on the painful areas of the body sometimes relieves the nerve pain. Willow bark has anti-inflammatory properties that will help relieve the inflammation of the nerve disorder. Working to reduce stress through natural remedies such as meditation often relieves the pain of this condition.
Not all patients with shingles or postherpetic neuralgia respond to stress relief for their pain. In some of the cases that have been helped with this alternative treatment, the condition has been cured completely. There has not been enough research in this area to effectively determine whether the alternative remedies will work for a larger group of those suffering from the painful condition.



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