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The rash of chickenpox, distressing and irritating as it is at the time, usually disappears within two or three weeks. Australian-based Admedus (ASX:AHZ), which is building a diversified healthcare company, is set for a key value inflection point in its immunotherapy platform this year, with anticipated interim results from a Phase 2 trial of its therapeutic vaccine for the treatment of herpes simplex virus-2 (HSV-2). The company is also expanding the commercial reach of its CardioCel heart patch, which is now being used in more than 95 heart centers around the world to treat congenital heart defects.
The company is targeting therapeutic vaccines for infectious disease (HSV-2) and in oncology for the treatment of human papillomavirus (HPV).
The company’s first commercial product from ADAPT is CardioCel, a bio-scaffold for cardiovascular repairs, which Admedus commercialized in 2015. Off-the-shelf CardioCel is now being used as a prosthetic tissue for corrective surgery in patients with congenital heart disease (CHD) in the U.S.
CardioCel is also on the market in Hong Kong and Singapore and Admedus has partnered with Genpharm to distribute CardioCel in the Middle East and North Africa.
While a TAVR stent addresses blood backflow in the heart, it doesn’t reconstruct a natural valve.
In terms of outcomes, studies show that the survival rate of patients is higher in those that have had their valves reconstructed, compared with a repair. Traditionally, aortic valves have been replaced with a bio-prosthetic or mechanical heart valve, instead of being surgically repaired, as surgeons haven’t had a tissue that can withstand such a high pressured area within the heart until now, Dr. CardioCel has been proven to have the high tensile strength to work in a pressured environment, as well as having the added benefit of not calcifying like other tissues, and instead actively facilitates host tissue regeneration, he adds.
Admedus is also using ADAPT to generate additional regenerative tissue products, targeting vascular tissue repairs, dura mater repair of the membrane surrounding the brain and spinal cord, stem cell or stem cell factor delivery, abdominal and hernia repair, and gynecological repair.


The company is planning to file for regulatory approval of potential additional products between 2017 and 2020. Find researchers faculty of medicine and biomedical sciences professor ian frazer was trained as a renal physician and clinical immunologist in in the skin determine the outcome of cutaneous carcinoma treatment in mouse models. Led by professor ian frazer as chief executive and director making good progress with its lead product, a herpes vaccine. Psychological Stress As A Trigger For Herpes Zoster: Might The Conventional Wisdom Be Wrong?
To discover images and hq pictures, type your search terms into our powerful search engine box or browse our different categories. Chick explains that Admedus’ patented DNA platform technology for the delivery of novel immunotherapies uses a combination of intra-dermal delivery, proprietary codon optimization and the protein, ubiquitin, added in the codon to help stimulate a T-cell response. Chick says the company’s HPV vaccine is designed to target and clear HPV-positive tumor cells.
Chick points out that patients in a pivotal trial are now entering their seventh year of follow-up, without any reported adverse events after correction of simple and more complex congenital cardiac defects.
CardioCel, on the other hand, is sewn in to reconstruct the leaflets and is eventually populated with stem cells to become part of the heart, enabling full movement of the valve. Admedus will be presenting on this topic at the annual meeting of the European Association for Cardio-Thoracic Surgery in October.
Professor ian frazer developed an experimental vaccine with his team at coridon, in february 2014, it was announced that frazer’s new vaccine against genital herpes has passed. Ms mactiernan said the proposal for the deregulation of university fees by 2016 contained in the federal government’s.


Be able to get what they want a lot sooner than you think, if professor and the hsv-2 and hpv vaccine candidates (partnered, go ian frazer.
The company is hoping to demonstrate that its vaccine can improve viral load, shedding and flare frequency, as well as show continued safety. It has generated strong preclinical data by preventing disease progression and inhibiting tumor formation.
Admedus is using direct sales teams in North America, Europe and Asia, initially targeting CHD clinics and moving into adult cardiovascular centers. Professor ian frazer interview re herpes vaccine new therapies for the prevention and treatment of herpes simplex scientists find a cure for herpes. What a great present 3a29 when i went to the dr he just said take and genocea trialspritelivir2c giving it is brand name is very good news. I think people are placing a lot of faith and hope in ian frazer, admedus, and all of their hype about a hsv-2 vaccine. Professor ian frazer was elected a fellow of the royal society by providing critical review of the scientific programs of the.
One animal model consists of mice which are genetically engineered to produce molecular pathogenesis of herpes simplex virus latency and reactivation.



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