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XYZ is well absorbed, with an absolute oral bioavailability of 80% (20% coefficient of variation [CV]).
XYZ este bine absorbita, avand o biodisponibilitate orala absoluta de 80% (20% coeficient de variatie [CV]).
Administrarea XYZ impreuna cu alimentele are un impact minim asupra absorbtiei medicamentului. A common side effect of chemotherapy is a decrease in the number of certain white blood cells, called neutrophils.
One of the ways to avoid or shorten the neutropenia phase after chemotherapy is by using drugs that help the bone marrow to produce neutrophils. Translation - RomanianDumneavoastra ati fost solicitata sa participati la un studiu de cercetare privind noul medicament experimental ABC. O reactie adversa frecventa a chimioterapiei consta in scaderea numarului anumitor celule albe in sange (leucocite), denumite neutrofile.
Neutropenia afecteaza mai mult de unul din trei pacienti carora li se administreaza chimioterapie.
Una din modalitatile de a evita sau de a diminua faza de neutropenie dupa chimioterapie consta in utilizarea unor medicamente care ajuta maduva osoasa sa produca neutrofile. The system consists of two primary components: an injection port with a self-sealing silicone septum and a radiopaque silicone or ChronoFlex® polyurethane catheter. Sistemul consta din doua componente principale: un port injector cu o membrana autoadeziva din silicon si un cateter radioopac din silicon sau din poliuretan ChronoFlex®. English to Romanian: Surgical instrumentsSource text - EnglishThe ABC Arterial Tamper consists of a wire snare with a locking knob on the proximal end. The ABC Arterial Tamper is designed to apply direct pressure on the arteriotomy by traction on the sutures. If hemostasis is not adequate after attempts to fully advance the knots, use the Arterial Tamper or compression. The ABC Arterial Tamper is indicated for the augmentation of hemostasis by positioning it over the access site and applying local pressure to the artery by securing the placement with the tied sutures. Translation - RomanianDispozitivul de inchidere arteriala ABC consta dintr-o ansa de sarma cu un maner de blocare la extremitatea proximala. Dispozitivul de inchidere arteriala ABC este conceput pentru a aplica o presiune directa la nivelul arteriotomiei, prin tractiune asupra suturilor. Daca hemostaza nu este adecvata dupa incercarile de strangere completa a nodurilor, utilizati dispozitivul de inchidere arteriala sau comprimarea. Dispozitivul de inchidere arteriala ABC este indicat pentru amplificarea hemostazei prin pozitionarea acestuia la nivelul locului de acces si prin aplicarea unei presiuni locale la nivelul arterei, asigurand pozitionarea prin suturi stranse. I viaggi sono stati altri, spesso faticosi, come il primo lungo cammino che mi aspettava dopo quel fatidico compleanno. Cosi, nel mio diario di viaggio, stipo ricordi che non si catturano con la macchina fotografica … le voci dei miei avi siciliani che vibrano tra i ruderi di Selinunte … lo sguardo dei ragazzi di strada di Johannesburg, venuti da noi e restii a tornare nella loro terribile realta … le lacrime dei veterani dello sbarco a Pachino tornati su quella stessa spiaggia a distanza di 60 anni … la neve che fiocca sul filo spinato di Auschwitz … la paura dei miei compagni di viaggio nella malattia che, avendo portato via mio padre, torno a chiamare anche me. Calatoriile au fost altele, deseori obositoare, asa cum a fost primul drum lung care ma astepta dupa acea aniversare fatidica. Colpisce in uguale misura maschi e femmine (una persona su 100) e si manifesta soprattutto nell’eta compresa tra 10 e 30 anni. E dovuta alla distruzione, probabilmente da parte di anticorpi, dei melanociti (le cellule che hanno il compito di produrre la sostanza scura, chiamata melanina, che colora la pelle).
L’andamento della malattia e assai variabile, anche se e abbastanza caratteristica la rapida insorgenza delle macchie, seguita da una lunga fase di relativa stabilita o di lenta progressione. Le parti maggiormente colpite sono: il viso, il collo e le superfici esposte a traumi, come le mani, i gomiti, le ginocchia, le caviglie e i piedi.
La malattia non provoca, in genere, decolorazione dei peli o dei capelli ed e molto raro che una persona colpita da vitiligine possa riacquistare spontaneamente il colore normale della pelle. Translation - RomanianVitiligo este o boala de piele caracterizata prin aparitia de pete de culoare alba, de diverse dimensiuni, care au tendinta sa se largeasca in mod progresiv si sa se uneasca intre ele in pete din ce in ce mai mari.
Afecteaza barbatii si femeile in egala masura (o persoana din 100) si se manifesta in special la varste cuprinse intre 10 si 30 ani. Boala se datoreaza distrugerii melanocitelor, probabil de catre anticorpi (melanocitele sunt celule a caror functie consta in producerea unei substante de culoare inchisa, denumita melanina, care coloreaza pielea).
Evolutia bolii este foarte variabila; cu toate acestea, aparitia rapida a petelor este destul de caracteristica si este urmata de o faza lunga de stabilitate relativa sau de evolutie lenta. Partile cele mai afectate sunt: fata, gatul si suprafetele expuse traumatismelor, cum sunt mainile, coatele, genunchii, gleznele si picioarele.
Boala nu provoaca, in general, decolorarea firelor de par de pe corp sau a parului si este foarte rar posibil ca o persoana afectata de vitiligo sa poata redobandi in mod spontan, culoarea normala a pielii. Hard X-rays can penetrate solid objects, and their largest use is to take images of the inside of objects in diagnostic radiography and crystallography. The roentgen (R) is an obsolete traditional unit of exposure, which represented the amount of radiation required to create one electrostatic unit of charge of each polarity in one cubic centimeter of dry air.


The rad is the (obsolete) corresponding traditional unit, equal to 10 millijoules of energy deposited per kilogram. The sievert (Sv) is the SI unit of equivalent dose, which for X-rays is numerically equal to the gray (Gy). X-rays are generated by an X-ray tube, a vacuum tube that uses a high voltage to accelerate the electrons released by a hot cathode to a high velocity. In crystallography, a copper target is most common, with cobalt often being used when fluorescence from iron content in the sample might otherwise present a problem. X-ray fluorescence: If the electron has enough energy it can knock an orbital electron out of the inner electron shell of a metal atom, and as a result electrons from higher energy levels then fill up the vacancy and X-ray photons are emitted.
So the resulting output of a tube consists of a continuous bremsstrahlung spectrum falling off to zero at the tube voltage, plus several spikes at the characteristic lines.
In medical diagnostic applications, the low energy (soft) X-rays are unwanted, since they are totally absorbed by the body, increasing the dose.
To generate an image of the cardiovascular system, including the arteries and veins (angiography) an initial image is taken of the anatomical region of interest. A specialized source of X-rays which is becoming widely used in research is synchrotron radiation, which is generated by particle accelerators.
The most commonly known methods are photographic plates, photographic film in cassettes, and rare earth screens. Before the advent of the digital computer and before invention of digital imaging, photographic plates were used to produce most radiographic images. Since photographic plates are sensitive to X-rays, they provide a means of recording the image, but they also required much X-ray exposure (to the patient), hence intensifying screens were devised. Areas where the X-rays strike darken when developed, causing bones to appear lighter than the surrounding soft tissue.
Contrast compounds containing barium or iodine, which are radiopaque, can be ingested in the gastrointestinal tract (barium) or injected in the artery or veins to highlight these vessels. An increasingly common method is the use of photostimulated luminescence (PSL), pioneered by Fuji in the 1980s. The PSP plate can be reused, and existing X-ray equipment requires no modification to use them.
For many applications, counters are not sealed but are constantly fed with purified gas, thus reducing problems of contamination or gas aging.
Some materials such as sodium iodide (NaI) can "convert" an X-ray photon to a visible photon; an electronic detector can be built by adding a photomultiplier. Yahoo , Facebook , Facebook , Twitter , Twitter , Google+ , Google+ , Myspace , Myspace , Linkedin , Linkedin , Odnoklassniki , Odnoklassniki , Vkontakte , Vkontakte , Google , Google , Yahoo , Yahoo , Rambler , Rambler , Yandex , Yandex , Gmail , Gmail , Yahoo! Designers Manufacturers , ??????? ????????? - ?????????? ???????????? , Gorgian Wikipedia - Free Encyclopedia , ????????? ?????? ????????? , Cambridje Dictionary Online , ????????? ???????? ????????? ?????? ????????? , Oxford Advenced Learner's Online Dictionar? , ??????????? ?????? - moazrovne,net, ???
Peak plasma concentrations (Cmax) are observed between 7.5 hours after oral administration. Following administration with low, medium, and high-fat meals, increases in Cmax of approximately 16% were observed only following a high-fat meal. XYZ is primarily metabolised by conjugation to the O-glucuronide, and to a minor extent through oxidative metabolism. XYZ is not a substrate for, or an inhibitor of, the P-glycoprotein transporter based on in vitro data.
In urma administrarii unor alimente cu continut redus, mediu si crescut de lipide, s-au observat cresteri ale Cmax de aproximativ 16% numai dupa consumul de alimente cu continut lipidic crescut. XYZ este metabolizata in primul rand prin conjugare la O-glucuronid si, in mai mica masura, prin metabolizare oxidativa.
Ati fost diagnosticata cu cancer mamar si – asa cum ati discutat cu investigatorul dumneavoastra- veti primi chimioterapie pentru a controla cresterea tumorii dumneavoastra. Pacientii cu neutropenie pot sa prezinte febra si sunt expusi unui risc crescut de infectii.
Toate materialele sunt biocompatibile si pot fi practic utilizate cu orice solutie injectabila. Quel giorno mi dissi che avrei viaggiato in tutti quei luoghi esotici e lontani che mi attiravano con promesse di appagamento di ogni specie. Solo adesso, entrando nel secondo mezzo secolo della mia vita, accetto che va bene lo stesso non essere andata alle Maldive, non aver preso l’Orient Express, non aver soggiornato al Ritz. Un crudo e buio viaggio verso la maturita, tenendo per mano un padre che chiudeva il suo soggiorno terreno ben troppo presto. Doar acum, intrand in cea de-a doua jumatate de secol a vietii mele, accept ca se poate si fara sa ma fi dus in Maldive, fara sa ma fi urcat in Orient Express sau fara sa fi stat la Ritz.
O calatorie cruda si intunecata catre maturitate, tinand de mana un tata care isi termina existenta terestra mult prea devreme. Il ciclo puo ripetersi per molte volte ed in rari casi si puo arrivare alla completa perdita di melanina.


Ciclul se poate repeta de mai multe ori si in cazuri rare se poate ajunge la pierderea completa de melanina. This process produces an emission spectrum of X-ray frequencies, sometimes referred to as the spectral lines. The intensity of the X-rays increases linearly with decreasing frequency, from zero at the energy of the incident electrons, the voltage on the X-ray tube. A second image is then taken of the same region after iodinated contrast material has been injected into the blood vessels within this area. The contrast compounds have high atomic numbered elements in them that (like bone) essentially block the X-rays and hence the once hollow organ or vessel can be more readily seen. In modern hospitals a photostimulable phosphor plate (PSP plate) is used in place of the photographic plate.
Approximately 19% of the administered dose is excreted as the glucuronide metabolite and ?5% as the oxidative metabolite (N,O-didesmethylvenlafaxine) in urine.
In cazul administrarii unei doze zilnice unice, concentratiile plasmatice la echilibru se obtin in aproximativ 4-5 zile. Aproximativ 19% din doza administrata se excreta in urina sub forma de metabolit glucuronid si English to Romanian: Clinical trialSource text - EnglishYou have been asked to participate in a research study of the investigational new drug ABC. Vi se va solicita sa luati un nou medicament pe durata tratamentului dumneavoastra chimioterapic. Accesul Port este efectuat prin insertia transcutanata a unui ac, utilizand un ac nepenetrant.
In ziua aceea mi-am spus ca voi calatori in toate acele locuri exotice si indepartate, care ma atrageau cu promisiunea de a-mi implini orice fel de dorinte. Poate ca mai am inca timp de toate acestea sau poate ca, de fapt, nici nu are prea mare importanta pentru mine.
The spectral lines generated depend on the target (anode) element used and thus are called characteristic lines. These two images are then digitally subtracted, leaving an image of only the iodinated contrast outlining the blood vessels.
Photographic film largely replaced these plates, and it was used in X-ray laboratories to produce medical images.
In the pursuit of a non-toxic contrast material, many types of high atomic number elements were evaluated. After the plate is X-rayed, excited electrons in the phosphor material remain "trapped" in "colour centres" in the crystal lattice until stimulated by a laser beam passed over the plate surface.
Electrons accelerate toward the anode, in the process causing further ionization along their trajectory. The plasma protein binding of desvenlafaxine is low (30%) and is independent of drug concentration. CYP3A4 is the predominant cytochrome P450 isozyme mediating the oxidative metabolism (N demethylation) of XYZ. La starea de echilibru, acumularea dozelor multiple de XYZ este lineara si se poate calcula din profilul farmacocinetic al dozei unice.
Legarea XYZ de proteinele plasmatice este scazuta (30%) si este independenta de concentratia medicamentului.
You have been diagnosed with breast cancer and – as discussed with your investigator – you will receive chemotherapy to control the growth of your tumour.
The radiologist or surgeon then compares the image obtained to normal anatomical images to determine if there is any damage or blockage of the vessel. In more recent years, computerized and digital radiography has been replacing photographic film in medical and dental applications, though film technology remains in widespread use in industrial radiography processes (e.g. For example, the first time the forefathers used contrast it was chalk, and was used on a cadaver's vessels. This process, known as a Townsend avalanche, is detected as a sudden current, called a "count" or "event". When the film is developed, the parts of the image corresponding to higher X-ray exposure are dark, leaving a white shadow of bones on the film. Photographic plates are mostly things of history, and their replacement, the "intensifying screen", is also fading into history. The metal silver (formerly necessary to the radiographic & photographic industries) is a non-renewable resource. Thus it is beneficial that this is now being replaced by digital (DR) and computed (CR) technology. Where photographic films required wet processing facilities, these new technologies do not.



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