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Cause: Males with Klinefelter's Syndrome receive an extra X chromosome, thus giving them 47 rather than the normal 46 chromosomes (an extra sex chromosome).
47XXY, the most common of the sex chromosome variations, is said to occur in 1 out of 500 males.
Cause: Turner's Syndrome is caused by a condition known as Monosomy (absence of entire chromosome) of X chromosome for females. Turner's Syndrome occurs in approximately 1 of every 2,000 female births and in as many as 10% of all miscarriages. Cause: Angelman Syndrome is caused by the deletion of genetic material on maternally inherited chromosome 15. Symptoms: Symptoms of Down Syndrome include small ears, small mouth, upward slanting eyes, flattened nose, decreased muscle tone at birth, wide hands, delayed mental development, eye problems, hearing problems, hypothyroidism, hip problems, sleep apnea, etc.
Life expectancy for people with Down syndrome has increased dramatically in recent decades - from 25 in 1983 to 60 today.
The incidence of births of children with Down syndrome increases with the age of the mother. Symptoms: Low-set ears, mental deficiency, small head, small jaw, unusually shaped chest, low birth weight, crossed legs (as a preferred position), congenital heart disease, kidney problems, cleft or hole in iris, etc. Symptoms: Cleft lip, decreased muscle tone, severe mental retardation, small eyes, small head, undescended testicles, low-set ears, seizures, close-set eyes, skeletal abnormalities, clenched hands, umbilical hernia, extra fingers or toes, etc. Symptoms: Forgetfulness of recent events and conversations, difficulty in multi-tasking, difficulty in solving problems, misplacing entities, language problems, flat mood, change in sleep patterns, difficulty reading or writing, poor judgment, loss of ability to reason or to recognize danger, difficulty doing basic activities, loss of ability to recognize family, inability to understand language, swallowing problems, etc. Cause: Parkinson's disease is caused by slow destruction of dopamine-producing nerve cells in the brain. Symptoms: Automatic movements (such as blinking) slow or stop, drooling, lack of expression in the face, shaking, tremors, quieter speech, monotone voice, rigid or stiff muscles, confusion, dementia, memory loss, fainting, impaired balance, muscle aches and pains, etc.
Approximately 60,000 Americans are diagnosed with Parkinson's disease each year (excluding undetected or undiagnosed cases).

If 4 million children are born in the United States every year, approximately 36,500 children will eventually be diagnosed with an autism spectrum disorder (ASD). Cause: Cri Du Chat ("Cry of the cat") Syndrome is caused by missing portions of chromosome 5.
Primarily Affects: Both males and females, with females having a slightly higher frequency. Symptoms: Symptoms of Cri Du Chat Syndrome include a high pitched cry in infants which is similar to that of cats, mental retardation, small head, small jaw, low birth weight, slow growth, abnormally shaped or low-set ears, slow or incomplete development of motor skills, wide set eyes, webbing or fusing of fingers or toes, downward slanted eyes, low muscle tone, separated abdominal muscles, etc.
Symptoms: Attacks of abdominal pain, fatigue, fever, rapid heart rate, bone pain, delayed growth and puberty, jaundice (yellowing of eyes and skin), breathlessness, chest pain, excessive thirst, poor eyesight, strokes, etc.
Sickle cell anemia is more prevalent in persons of African descent: The disease occurs in about 1 out of every 500 African Americans births. Genetic transformation: A process by which the genetic material carried by an individual cell is altered by the incorporation of foreign (exogenous) DNA into its genome. Infantile genetic agranulocytosis: Children born with this condition lack neutrophils (a type of white blood cell that is important in fighting infection). Genetic disorders and diseases could not be treated at one time at all due to their genetic cause - gene therapy hopes to remove this obstruction rapidly and quickly. It is often counted as a "sister disorder" to Prader-Willi Syndrome due top to occurrence in same genetic area. Symptoms include seizures, jerky movements, speech impairments, small head size, hyperactivity, motor difficulties, etc. People with particular variation in gene MTHFD1L may be nearly twice as likely to develop late- onset Alzheimer’s disease, the most common kind. Children inheriting mutated form of a gene on chromosome 11, for example, are unable to break down amino acid phenylalanine.
General symptoms include difficulty in social interaction and pretend play in childhood, difficulty to start or to maintain conversations, repeated body movements, unusual attachment to objects, slow development of language, repetition of memorized word, withdrawn behavior, lack of sensitivity in terms of stimulus, narrow interests, short attention span, etc.

Breast cancer, for example, is caused by inheriting a variation of the BRCA 1 or BRCA 2 gene. Cancer exists in various forms, and prevalence varies according to form as well; Breast cancer, for example, primarily affects females. Generally, most cancers cause fever, loss of appetite, fever, weight loss, uncontrollable growth of an area with a tumor, fatigue, malaise, etc. Although various forms of sickle cell anemia exist, one prevalent form is caused by a single-nucleotide polymorphism (SNP) - in other words, one nucleotide is changed with another -, resulting in glutamic acid being replaced by valine as an amino acid during protein synthesis. These children suffer frequent infections from bacteria which in the past led to death in three- quarters of cases before 3 years of age. The Cancer Gene Index is a collection of records on 6,955 human genes identified from the literature as having an association with cancer. In childhood: sleep disorders, excessive weight gain, speech delay, hyperphagia (over-eating).
If the deficiency, called phenylketonuria (PKU), goes undetected, the child will develop mental retardation. Natural genetic transformation is the active uptake of free DNA by bacterial cells and the heritable incorporation of its genetic information. Adults with Prader-Willi Syndrome also often have increased amount of central fat, narrow foreheads, almond-shaped eyes, and delayed motor development.

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