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Researchers Continue to Develop Less Toxic Treatments for HPV+ Oropharyngeal CancersWhile the prognosis remains good for individuals with HPV-positive oropharyngeal cancers, researchers are currently seeking less intense treatment options that are equally effective but not as toxic.LAUREN M.
Talk about this article with other patients, caregivers, and advocates in the Head & Neck Cancer CURE discussion group.
While the prognosis remains good for individuals with HPV-positive oropharyngeal cancers, the incidence of these cancers continues to rise, and researchers are currently seeking less intense treatment options that are equally effective but not as toxic for patients.Oncogenic HPV infection is now a recognized etiology in approximately half of oropharyngeal squamous cell cancers. Bethany Andrews Rhoten, Assistant Professor of Nursing, Vanderbilt University, discusses how patients with cancer can cope with body image issues.
Bethany Andrews Rhoten, Assistant Professor of Nursing, Vanderbilt University, discusses body images among patients and survivors of head and neck cancer. Mayfield Clinic neurosurgeons use three different radiation technologies in the treatment of patients with primary or metastatic brain tumors, spinal tumors, and other neurological abnormalities, such as trigeminal neuralgia, arteriovenous malformations, cavernous angiomas, and chronic pain. NovalisA® Shaped Beama„? Surgery system uses image guidance and precisely targeted x-ray beams to safely treat tumors and other abnormalities of the brain and spine.
TrueBeama„? enables precise, shaped-beam radiosurgery and radiotherapy of almost any tumor or abnormality. Gamma KnifeA® uses precise, high-intensity gamma rays to target lesions in a single session. Mayfield Clinic neurosurgeons based at The Jewish Hospital a€“ Mercy Health are now using Gamma KnifeA® to treat patients with benign, malignant, and metastatic brain tumors.


Radiosurgery uses high doses of radiation in 1, 3 or 5 treatments, while radiotherapy uses lower doses of radiation given in as many as 30 to 35 treatments.
In both radiosurgery and radiotherapy, specialists use some of the same navigation tools of surgery, which allow the precise location of the lesion, or tumor. Precision Radiotherapy, a partnership of the Mayfield Clinic and UC Healtha€™s Department of Radiation Oncology, provides skilled, compassionate care to 80 patients each day at its West Chester, Ohio, location. We have more than 20 years of experience in the safe delivery of complex radiation treatments.
Our efforts are also reflected in patient satisfaction surveys, with 97 percent of patients providing high marks for overall satisfaction, quality of care, confidence in our team, and the likelihood that they will recommend Precision Radiotherapy to others.
In addition to providing state-of-the-art clinical care, Precision Radiotherapy Center contributes $300,000 annually to the UC Brain Tumor Center for research and education. Learn more about radiotherapy and radiosurgery from our partners at Precision Radiotherapy.
Using electron beam radiotherapy, TrueBeama„? can also treat tumors that are close to the surface of the body, including skin cancers. Chris McPherson explains how image-guided surgery (IGS) technology is used in the operating room.
Radiation works by damaging the DNA inside cells and making them unable to divide and reproduce, therefore causing them to die.


But instead of being removed with a knife, tumors are ablated with a machine: either a linear accelerator that delivers X-ray or electron beams or a Gamma Knife that delivers high-intensity gamma rays from a cobalt source. Our specialists are certified by the American Board of Radiology, and our safety protocols call for daily, weekly, monthly, and annual checks of the accuracy of our equipment. Patients are immobilized with a rigid head frame that is secured with small, titanium pins.
More than 30 years of clinical studies documented in more than 2,500 published medical papers have underscored the safety and effectiveness of Gamma KnifeA® radiosurgery. Similar to a GPS for your car, an IGS system helps the surgeon locate and safely navigate in the brain to remove tumors and other lesions. Our team pioneered frameless radiosurgery with the NovalisA® system, and we have published 15 academic articles in national, peer-reviewed journals. All this makes patient selection crucial, said Haigentz.Several strategies for treatment deintensification for HPV-positive oropharyngeal cancers are under clinical evaluation, for example, replacing concurrent cisplatin with Erbitux (cetuximab) or reducing radiation doses.



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