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Rutgers research provides clues to keeping brain cells alive in those with Alzheimer’s Friday, October 2, 2015By Robin LallyCan you imagine a drug that would make it easier to learn a language, sharpen your memory and help those with dementia and Alzheimer’s disease by rewiring the brain and keeping neurons alive? People with a dementia such as Alzheimer's disease lose their memory when brain cells shrink and die because connections can no longer transfer information.
New Rutgers research published in the Journal Neuroscience found that a drug – RGFP966 – administered to rats made them more attuned to what they were hearing, able to retain and remember more information, and develop new connections that allowed these memories to be transmitted between brain cells. What happens with dementias such as Alzheimer’s is that brain cells shrink and die because the synapses that transfer information from one neuron to another are no longer strong and stable.
The drug administered in this animal study is among a class known as HDAC inhibitors – used in cancer therapies to stop the activation of genes that turn normal cells into cancerous ones. Scientists also found that the rodents were more “tuned in” to the relevant acoustic signals they heard during their training – an important finding Bieszczad said because setting up the brain to better process and store significant sounds is critical to human speech and language. This hypersensitivity in processing the auditory information enabled the neurons in the rats brains to reorganize and create new pathways – allowing more of the information they learned to become a long-term memory, said Bieszczad who collaborated with colleagues in the Department of Neurobiology and Behavior at the University of California Irvine.
Researchers at Georgetown University have found that an anti-malaria drug can be used to treat Tamoxifen resistant breast cancer.
The researchers indicated that, while it is too early to draw any long term conclusions from their research, they are optimistic that HCQ allowed mice with Tamoxifen resistant breast cancer to continue Tamoxifen treatment.
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When checked, Shutterstock's safe search screens restricted content and excludes it from your search results. In the brain, the drug makes the neurons more plastic, better able to make connections and create positive changes that enhance memory. The researchers inserted cancerous tumors into mice with serious postmenopausal estrogen receptor-positive breast cancer. 2D chemical structures of the 20 common amino acids found in proteins, with atoms represented as conventionally color-coded circles.
Atoms are represented as spheres with conventional color coding: hydrogen (white), carbon (grey), nitrogen (blue), oxygen (red). Everyone who signs up gets full access to our entire library, including our curated collections. Our Standard license allows you to use images for anything, except large print runs over 500,000+ or for merchandising. Once you have downloaded your image, you have life-long rights to use it under the terms of the license purchased. Researchers found that laboratory rats, taught to listen to a certain sound in order to receive a reward, and given the drug after training, remembered what they learned and responded correctly to the tone at a greater rate than those not given the drug. When HCQ is used to treat Tamoxifen resistant breast cancer in combination with the Tamoxifen drug, the breast cancer’s resistance to Tamoxifen is reversed.


He went on to say that the inexpensive nature and safety of both drugs will allow for easier access and treatment.
This form of breast cancer is one of the most common and is usually treated with the Tamoxifen drug. Conventional skeletal formula and stylized representation, showing atoms (except hydrogen) as color coded circles. If at any time you're unsatisfied with your experience with us, you can cancel your subscription.
The results of the research were published in the June edition of Clinical Cancer Research.
This can become problematic because nearly half of patients treated with Tamoxifen become resistant to it or do not respond to the treatment.
The research conducted at Georgetown indicates that those patients could potentially still be treated with Tamoxifen instead of higher priced drugs or treatments that are difficult to maintain.




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