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The study, published online in the British journal Clinical Infectious Diseases, was conducted by researchers from the NICHD, Case Western Reserve University, Emory University and the Civic Association for Health and Education in Peru.
Earlier studies have shown that Valacyclovir reduces HIV levels in patients co-infected with HIV and herpes simplex virus 2 (HSV-2), the virus that causes genital herpes. Previously, this effect has been attributed to the drug's anti-HSV-2 activity, which then results in fewer active immune cells for HIV to infect.
Yet, the new study indicated that the drug likely reduced HIV levels by interfering directly with HIV's reproductive machinery and did not require the presence of HSV-2. According to the researchers, HSV-2 chemically alters Valacyclovir, by attaching chemical groups known as phosphates to it, resulting in an altered form of the drug that suppresses HSV-2.


In the new study, researchers enrolled 18 HIV-infected patients, none of whom were infected with HSV-2, and treated them with Valacyclovir.
Half of the patients took Valacyclovir twice a day for 12 weeks, while the other half received a placebo. When the patients took Valacyclovir, their blood HIV levels declined significantly, and when they took the placebo, their HIV levels went up.
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Valacyclovir, a drug commonly used to treat genital herpes, may help reduce the levels of HIV, the virus that causes AIDS, even when patients do not have herpes, a study has suggested.


After two weeks, the placebo group received Valacyclovir while the group originally treated with the drug switched to the placebo.



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Comments
  1. Naxchigirlka 16.02.2015 at 15:38:14
    Aware they are carrying this disease the painful sores brought.
  2. HANDSOME 16.02.2015 at 21:53:32
    Researchers will proceed to observe stays within the.
  3. jakira 16.02.2015 at 22:55:12
    The lips, it may be herpes (oral herpes) that many individuals who once suffered tremendously extended - longer.