During aging, the body experiences some physiological changes as the cellular functions fall back. For instance, the body depletes NAD+ and SIRT1 proteins than it can synthesize. Low levels of these coenzymes accelerate senescence while sparking off age-related comorbidities including diabetes, cardiovascular diseases, and obesity.
Administering nicotinamide riboside chloride benefits the immune system by boosting the blood vessels, such as lymphocytes and leucocytes. The compound upregulates the synthesis of NAD+, hence, stepping up the levels of SIRT1 proteins. Consequently, SIRT1 slows down vascular aging by increasing blood flow to the skeletal muscles, cardiovascular system, and the neurological tissues.
Besides, nicotinamide riboside chloride supplement reverses aging by producing more NAD+ to aid in DNA repair within the cellular structure. This effect prevents oxidative stress
The available research also confirms that nicotinamide riboside chloride counters bone density depletion, a decrease in tear production, and fundus hypopigmentation. All these conditions are pervasive among the elderly.
The demand for Nicotinamide Riboside supplements has increased considerably over the last few years, primarily because Nicotinamide Riboside has many advantages. If you are looking to foray into the Nicotinamide Riboside supplements market, the first thing you must do is find yourself a trustworthy and reliable raw materials supplier. Where to buy Nicotinamide Riboside Chloride powder in bulk? The answer is Cofttek.
Cofttek is a raw materials supplier that came into existence in 2008 and in only about a decade, the company has established its presence in several countries. Other than producing reliable products, the company is also focussed on making advances in the field of biotechnology, chemical technology and chemical testing. The company is also committed to quality research, which gives it an edge over other suppliers in the market. The Nicotinamide Riboside Chloride powder provided by the company comes in batches of 25 kgs and can be trusted for quality. Moreover, the company has excellent sales and customer support team which will take care of all your needs and enquiries in real-time. This, if you want to buy Nicotinamide Riboside Chloride powder in bulk, trust only Cofttek.
Conze, D., Brenner, C., & Kruger, C.L. (2019). Safety and Metabolism of Long-Term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-Controlled Clinical Trial of Healthy Overweight Adults. Scientific Reports.
Bogan, K.L. & Brenner, C. (2008). Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ precursor Vitamins in Human Nutrition. Annual Review of Nutrition.
Mehmel, M., Jovanovic, N., & Spitz, U. (2020). Nicotinamide Riboside – The Current State of Research and Therapeutic Uses.
Turck, D., Castenimiller, J., et al. (2019). Safety of Nicotinamide Riboside Chloride as a Novel Food Pursuant to Regulation (EU) 2015/2283 and Bioavailability of Nicotinamide from this Source, in the Context of Directive 2002/46/EC. EFSA Journal.
Elhassan, Y.S. et al. (2019). Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-Inflammatory Signatures. Cell Reports.
Aman, Y., Qiu, Y., Tao, J., & Fang, E.F. (2018). Therapeutic Potential of Boosting NAD+ in Aging and Age-Related Diseases. Translational Medicine of Aging.