How Does Oleoylethanolamide (OEA) Work?
What is Oleoylethanolamide(OEA)?
Oleoylethanolamide(OEA) is an endogenous peroxisome proliferator-activated receptor alpha (PPAR-alpha) agonist. It is a naturally occurring glycolamide lipid with a variety of unique homeostasis properties such as appetite control, anti-inflammatory activity, stimulation of lipolysis and fatty acid oxidation. Oleoylethanolamide can be considered a hormone of the intestinal brain axis. Oatmeal, nuts, and cocoa powder are the major foods sources of Oleoylethanolamide in meals. However, the amount of Oleoylethanolamide found in these foods is low (fewer than 2 µg / g).
As a biologically active lipid medium, oleylethanolamide (OEA) is produced in the intestine and other tissues, and is involved in mammalian energy balance regulation, regulating food intake and lipid metabolism, such as it can regulate Vertebrate food and body weight. Oleoylethanolamide is a fatty acid ethanolamide (FAE), a monounsaturated analog of endocannabinoid arachidonic acid ethanolamide (anandamide), and a functional antagonist of anandamide. It is worth noting that Oleoylethanolamide is different from anandamide, it is independent of the cannabinoid receptor, and exerts its biological function through other pathways, regulating PPAR-α activity to stimulate lipolysis. Oleoylethanolamide is a potential and safer anti-obesity drug that replaces CB1 antagonism.
Preclinical studies have shown that Oleoylethanolamide is also an effective anti-inflammatory and antioxidant compound that exerts neuroprotective effects in alcoholism. Exogenous administration of Oleoylethanolamide can effectively prevent alcohol-induced TLR4-mediated proinflammatory cascades, thereby reducing the release of proinflammatory cytokines and chemokines, oxidative and nitrosative stress, and ultimately prevents nerve damage in the frontal cortex of rodents.
How Does Oleoylethanolamide (OEA) Work?
In obese people, OEA can regulate the energy homeostasis and appetite mainly by activation of various receptors including proximal proliferator-activated receptor-α (PPAR-α), G-protein-coupled receptor 119 (GPR119) and transient receptor potential cation channel subfamily V (TRPV1). Indeed, OEA activates these receptors and delays meal initiation, reduces meal size, decreases intervals between meals and finally modulates body weight.
Moreover, some experimental studies shows that OEA also suppresses the expression of IL-6, interleukin-8 (IL-8), intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in TNF-α induced inflammation in human umbilical vein endothelial cells through the activation of inflammatory receptors. OEA also inhibited the nuclear factor kappa-B (NF-kB) pathway in the body. In YT et al’s survey, OEA (50 µmol/L) inhibited the TNF-α induced VCAM-1 expression in HUVEC.
Oleoylethanolamide (OEA) Mechanism of action
Oleoylethanolamide (OEA) functions as an appetite regulator. Oleoylethanolamide controls your food intake by sending signals to the brain informing it that you’re full, and it’s time to stop eating. As a result, you take less food on a daily basis, and your body stops packing more weight in the long term.
Oleoylethanolamide (OEA ) (111-58-0) is produced and mobilized in the small intestine from oleic acid derived from the diet. Food with high fat content can inhibit production of Oleoylethanolamide in the proximal small intestine.
Oleoylethanolamide lowers food intake by stimulating histamine brain circuitry, homeostatic oxytocin, and hedonic dopamine pathways. It is evident that Oleoylethanolamide can also attenuate CB1R signaling, which if stimulated may lead to increased food intake. Oleoylethanolamide decreases lipid transport into adipocytes to lower fat mass.
OEA also functions to stimulate something known as PPAR and simultaneously lowers fat storage and increases burning of fat. Whenever you take a meal, the levels of OEA rises and your appetite falls. This happens because the sensory nerves linked to your brain inform it that you are full thanks to the PPAR-α. PPAR-α is a ligand-activated nuclear receptor which is involved in energy homeostasis pathways and gene expression of lipid metabolism.
Oleoylethanolamide (OEA) showcases all characteristics that defines satiety factor which include:
Inhibiting feeding by increasing the time interval between one meal to the next meal;
Its production is controlled by availability of nutrients
Its levels undergo circadian fluctuations.
The raw material supplier of Oleoylethanolamide (OEA)
One can purchase an OEA drug from a reputed and proficient drug store located nearby your dwelling place or can even buy it by ordering online. But one has to be very alert in this respect as all the suppliers of this drug might not be genuine.
So, always check the reputation and the proficiency of the online drug stores and for that, it is always advisable to go through the details of the reviews of the experienced purchasers. Be sure about the packaging of the product like whether it is properly sealed or not to avoid any type of contamination which can result in some dangerous issues in the health front.
Oleoylethanolamide (oea) in the form of powder
OEA in its original state is not found in the form of tablets or capsules. However, you can buy OEA powder in bulkin the market if required. This powder form is incorporated in the finished product by regularizing it to 15 % OEA or 50 % OEA oleic acid. The blueprint of Cima OEA is maintained between 90 % to 95 % especially among the purchasers of Europe and the United States.
Buy Oleoylethanolamide (OEA) powder in bulk
You can place an online order for bulk purchase of powder or can even buy from reputed local stores. Storage is pretty simple in the case of OEA powder. You need to store it at room temperature. But, it should not come in contact with the moisture or direct sun rays. So, you need to keep it tightly sealed in a cool and dry place.
STABILITY
Uses of OEAcan help you in many ways! For this reason, highly recommendable to everyone as it has no side effects. It can even induce a healthy lifestyle within your family making all of you grow and glow in shape, style, and with esteem and confidence. Keeping and maintaining your body in shape, especially for those who are a little bit obese, will not only make you feel happy but will also make others feel happy and proud too about you.
OEA will also help you to release out mental stress helping you to create a positive impression in others’ minds. Thus, instead of feeling upset and unhappy, it is high time to take an action and start using OEA and you will be extremely amazed to see its magical powers and you will feel healed and caressed.
References
a b c Rondanelli M1, et al. Administration of a dietary supplement ( N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: a randomized controlled trial. Br J Nutr. (2009)
a b Mangine GT1, et al. The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: a double-blind, randomized control trial. Lipids Health Dis. (2012)
a b c d e f g h i j k l m n Serrano A, et al. Oleoylethanolamide: effects on hypothalamic transmitters and gut peptides regulating food intake. Neuropharmacology. (2011)
Petrosino S, Di Marzo V. Anandamide and Other Acylethanolamides. Handbook of Neurochemistry and Molecular Neurobiology. (2010)
5. a b c d e f g h Fu J, et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. (2003)