The Dosage, Safty and Side Benefits of Phosphatidylserine (PS)

 

What is Phosphatidylserine (PS)?

Phosphatidylserine (PS) is a phospholipid and a compound that is very close to a dietary fibre commonly found in the human neural tissue. Phosphatidylserine plays a crucial role in clotting function and is vital for cognitive function as Phosphatidylserine facilitates the transferring of messages between nerve cells.

 

On average, a Western diet supplies close to 130 mg of Phosphatidylserine every day. Fish and meat are good sources of Phosphatidylserine, which is also found in sparse amounts in dairy products and vegetables. Soy lecithin is another good source of Phosphatidylserine. However, though Phosphatidylserine can be synthesized by the body as well as consumed through the diet in the form of natural sources, preliminary research shows that its levels decline with age. Thus, these days, Phosphatidylserine supplementation is promoted, especially in older individuals registering any decline in memory and cognitive function.

 

Over the last few years, the demand for Phosphatidylserine supplements has increased significantly since Phosphatidylserine supplements are considered a natural remedy for a variety of conditions, such as anxiety, Alzheimer’s, attention deficit-hyperactivity disorder, depression, stress and multiple sclerosis. That apart, Phosphatidylserine supplements are also known to enhance physical output, exercise performance, mood and sleep.

 

Why we need Phosphatidylserine (PS)

Some days, our brain feels like it has become clogged and cannot perform any function. In most cases, this happens due to declined cognitive function, a state more common to old people but not rare in young adults. Over the last few years, scientists and researchers have shown great confidence in Phosphatidylserine’s capability to treat diminished cognitive function. More importantly, growing research in the area has exposed people to other benefits of Phosphatidylserine, such as its ability to treat conditions, such as Alzheimer’s disease and ADHD as well as its ability to boost sleep and enhance mood.

PS works well with other supplements/ Phosphatidylserine Stack

Phosphatidylserine is often used together with other supplements that are known to enhance cognitive functioning in an effort to maximize its benefits.

For example, PS and Rhodiola rosea are used together to improve athletic performance. PS although well known for its benefit in relieving age-related memory decline, it has proven be an excellent nootropic supplement in sports nutrition. Studies show that PS reduces perceived stress that boosted golf scores and also resulted to healthy responses to stress.

On the other hand, Rhodiola rosea is a nootropic that enhances stress tolerance and better athletic performance. It has been in the ancient times and well known to enhance the body’s ability to cope with strenuous exercises.

The combination of these two supplements, PS and Rhodiola results in improved athletic performance due to their benefit in dealing with stress and also enhancing memory.

An independent study on 200 ADHD minors evaluated the effectiveness of Phosphatidylserine in combination with Omega 3’s on 30-weeks long trial.  The major finding of the study was a remarkable impulsive/restlessness scale reduction and a notable emotions improvement. The study deduced that Phosphatidylserine use with Omega 3 can lessen ADHD symptoms especially in a subset of behaviourally-deregulated and emotionally, hyperactive-impulsive ADHD children.

In children suffering from depressive disorder, phosphatidylserine use supplemented with omega-3 lipids improved cognition and attention and mitigated depressive symptoms.

Phosphatidylserine has also been demonstrated to boost other supplements known to improve the brain health. An example of such brain supplement is curcumin, a compound obtained from turmeric. Curcumin functions to improve the circulation of blood to our brain while also raise the release of serotonin and dopamine. However a major drawback with curcumin is in its difficulty in absorption. PS stacking hence comes in handy in this supplementation to increase the utilisation of curcumin.

PS has also been reported to work synergistically with other nutrients such as Ginkgo biloba and fish oil.

Guidelines for Use

(1) Recommended Dosage

The appropriate phosphatidylserine dosage may vary depending on the age, underlying health condition, and the intended outcome.

For adults, the recommended dosage of 100 mg taken three times a day is considered both safe and effective for slowing down memory decline.

Most clinical studies involving both children and adults have used a dosage of 200-400mg a day with no or mild side effects. However, it is advised to always start with the lowest effective dose of PS at 100 mg three times daily and adjust as necessary.

To reap maximum benefits from PS supplements, try taking PS 20 to 30 minutes before meals with enough water. Patience is needed when taking supplements as they take some time to exhibit maximum benefits. With phosphatidylserine use, it takes 3-9 months to realise significant improvements, especially with stress-related issues.

(2) Ailments Dosage

Some phosphatidylserine dosages have been studied including;

What are the risks/side effects of taking Phosphatidylserine?

Since phosphatidylserine (PS) occurs naturally in our body, it is considered safe and can be well tolerated. PS is therefore non-toxic.

Some concerns have been raised in regards to products made from animal sources that they could transmit diseases, such as the mad cow disease. However, these are only theoretic risks since there are no proven cases of diseases emanating from phosphatidylserine supplements derived from animal sources. But as the saying goes ‘better protection than cure’ be sure to look for plant-derived supplements.

Many consumers take the phosphatidylserine supplement derived from soy and sunflower with no side effects. Researchers show that when PS supplements are taken by mouth appropriately in a period of 3 months, they are considered safe. However, phosphatidylserine side effects have been reported with doses above 300 mg per day. Some people have reported phosphatidylserine side effects such as insomnia, gas, and unwanted energy boost and stomach upset.

Is Phosphatidylserine safe? (FDA, some research evidence)

Phosphatidylserine (PS) is found naturally in the human brain, hence considered safe as a nootropic supplement in any diet. Studies have proven its benefits to the brain in improving memory, relieving stress and enhancing learning and attention. Additionally, PS works well with other supplements to maximize its potential. When used appropriately it regarded safe.

 

Phosphatidylserine (PS) has received an FDA-qualified health claim as a nootropic, that says;

 

Phosphatidylserine (PS) can minimise the threat of cognitive decline in the elderly. However, FDA concludes that there is still minimal scientific evidence to support this claim.”

 

This means that PS is a safe supplement for your brain. However, take precaution when including any supplement in your diet by consulting your health care provider.

 

Where You Can Get Phosphatidylserine (PS)?

With people becoming more and more aware of the benefits of Phosphatidylserine (PS), the demand for Phosphatidylserine (PS) supplements has increased greatly in the market. This has led to manufacturing companies vying with each other to produce high-quality supplements to grab share in the market. If you are a health supplements manufacturer planning to foray into the Phosphatidylserine (PS) supplements market, you must ensure that you are getting the highest-quality Phosphatidylserine (PS) powder. Sourcing good-quality material is the first step in ensuring the success of any business.

 

If you are looking for a place to buy Phosphatidylserine (PS) powder in bulk, the one company you can blindly trust for sourcing raw material is Cofttek. The company, owing to its strong research team and dedicated sales department, has established a worldwide presence in only a short amount of time — it has clients and partners around the world. The Phosphatidylserine (PS) produced by the company comes in big batches of 25 kgs and is sourced from highest-quality ingredients, thereby ensuring that the supplements produced from it can be trusted for quality and efficacy. If you want to buy Phosphatidylserine (PS) in bulk, the only place to shop is cofttek.com.

 

 


 


 

REFERENCES

 

[1]. Phosphatidylserine. [No authors listed] Altern Med Rev. 1999 Apr;4(2):115-7.

PMID: 10231612

[2].Phosphatidylserine: A cancer cell targeting biomarker. Sharma B, Kanwar SS.Semin Cancer Biol. 2018 Oct;52(Pt 1):17-25. doi: 10.1016/j.semcancer. 2017. 08. 012. Epub 2017 Sep 1.PMID: 28870843 

[3].Phosphatidylserine. Pepping J.Am J Health Syst Pharm. 1999 Oct 15;56(20):2038, 2043-4. doi: 10.1093/ajhp/56.20.2038.PMID: 10541030

[4].Phosphatidylserine in atherosclerosis. Darabi M, Kontush A. Curr Opin Lipidol. 2016 Aug;27(4):414-20. doi: 10.1097/MOL.0000000000000298. PMID: 27070078

[5]. EFSA Panel on Dietetic Products, Nutrition and Allergies (2010-10-01). "Scientific Opinion on the substantiation of health claims related to phosphatidyl serine (ID 552, 711, 734, 1632, 1927) pursuant to Article 13(1) of Regulation (EC) No 1924/2006". EFSA Journal. 8 (10): 1749. doi:10.2903/j.efsa.2010.1749. ISSN 1831-4732.