<

The Most Basic Things You Need To

Know About PQQ

What is Pyrroloquinoline Quinone disodium salt ? The scientific name of PQQ is Pyrroloquinoline Quinone disodium salt (PQQ for short), which is a new prosthetic group that is bound by the membrane after flavin nucleotides (FMN, FAD) and nicotinamide nucleotides (MAD, NADP). The third prosthetic group found in bacterial dehydrogenase is called the fourteenth vitamin by the world medical community. PQQ (Pyrroloquinoline Quinone disodium salt) is a leading edge supplement that offers remarkable benefits for a versatile range of uses. This vitamin-like micronutrient can be found everywhere in nature — soil, plants, fruits, and animals. It is essential for a healthy mind, heart and body. In this article, we will introduce all the information about PQQ in detail for you. What is Pyrrole?
  1. Pyrrole is a five-membered heterocyclic compound containing a nitrogen heteroatom.
2) Pyrrole and its methyl-substituted homologues exist in bone tar. 3) Colorless liquid. 4) The boiling point is 130131℃, the relative density is 0.9691 (20/4℃). 5) Slightly soluble in water, soluble in organic solvents such as ethanol and ether. 6) Pyrrole is the basic structural unit of heme, chlorophyll, bile pigment, some amino acids, some alkaloids and some enzymes. What is Quinoline? 1) Quinoline is a colorless liquid and an aromatic compound. 2) It is miscible with alcohol, ether and carbon disulfide, easily soluble in hot water, but hardly soluble in high cold water. 3) Colorless liquid. 4) With hygroscopicity, it can absorb water from the air to 22% water content, and can volatilize with water vapor. 5) Colorless flake crystal or liquid. Melting point 26.48℃, boiling point 242.2℃ 6) The pharmaceutical industry is used to make niacin and 8-hydroxyquinoline drugs. What is Quinone? 1) Quinone compounds are aromatic organic compounds with a six-carbon cyclic diketone structure containing two double bonds. 2) Quinones or compounds that are easily converted into quinones are often found in nature as pigments in animals, plants, and microorganisms. 3) The main active ingredients of Chinese medicines such as rhubarb, cassia, senna, comfrey, polygonum cuspidatum, fleeceflower root, aloe vera, etc. contain quinone compounds. 4) Quinone compounds can be divided into benzoquinones, naphthoquinones, anthraquinones and phenanthrenequinones 5) Quinones have a highly conjugated structure, so they are all colored compounds. Paraquinones are mostly yellow and orthoquinones are mostly red or orange. Quinones PQQ physical and chemical properties The scientific name of PQQ is pyrroloquinoline quinone (Pyrroloquinoline quinone for short PQQ). It is a new prosthetic group that is bound by the membrane after flavin nucleotides (FMN, FAD) and nicotinamide nucleotides (MAD, NADP). The third prosthetic group found in bacterial dehydrogenase is called the fourteenth vitamin by the world medical community. As a new water-soluble vitamin, PQQ is an oxidoreductase prosthetic group. It is very rare and exists in some microorganisms, plants and animal tissues. It not only participates in catalyzing redox reactions in organisms, but also has some special biological activities and physiological functions. A large amount of PQQ can improve the metabolism and growth function of biological tissues, which is extremely precious. PQQ is very rare in some microorganisms, plants and animal tissues. The School of Life Sciences of Wuhan University uses redox methods to obtain a large amount from "Tai Sui" Ganoderma lucidum. Neurotrophic and protective effects of PQQ PQQ can reduce the content of NO by reducing the expression of nitric oxide synthase to promote the recovery of damaged spinal cord. Cerebral ischemia is an important cause of stroke. In the study of rat brain hypoxia/ischemia model, it was found that intraperitoneal injection of PQQ 30 min before injury can significantly reduce the scope of cerebral infarction without causing neurobehavioral side effects. A model of focal cerebral ischemia in the middle cerebral artery of an adult rat was prepared using the thread tying method, and the damage was found. PQQ research has gone deep into the cell signaling pathways related to mitochondria. PQQ can regulate mitochondrial generation and oxidative metabolism, and then regulate cell proliferation, differentiation and death. It can be seen that PQQ is very promising as a neurotrophic protective drug to play a role in the treatment of neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. The Main Functions of PQQ The wide array of PQQ’s benefits are all derived from three primary functions that it provides New Mitochondrial Growth: Mitochondria are the powerhouses of the cell and produce the vast majority of all cellular energy (ATP). PQQ activates a key transcription factor protein (CREB) and directly stimulates Mitochondrial Biogenesis, which is the growth and replication of new mitochondria. Stronger mitochondria, and more of them, produce more cellular ATP and thereby, users of PQQ may feel higher levels of natural energy. Powerful Antioxidant: Antioxidants protect your cells from damage inflicted by harmful molecules called free radicals. PQQ is an extremely potent antioxidant and is approximately 100 times more effective than Vitamin C at reducing these free radicals. A continuous supply of PQQ provides long-lasting protection and promotes the longevity of your heart, brain, liver and other organs rich in mitochondria. Nerve Cells Support: Nerve Growth Factor (NGF) is a large protein that plays a critical role in the growth, development and maintenance of neurons. PQQ has been found to promote NGF production, with one study showing as much as a 40x increase. Increased levels of NGF help to maintain the health of the brain and peripheral nerves while also stimulating nerve regeneration. This promotes more mental energy, greater focus, and better short-term memory. As a powerful antioxidant, a stimulator of mitochondrial biogenesis and a trigger of Nerve Growth Factor production, PQQ is a triple threat to cellular aging. Where you can buy pyrroloquinoline quinone disodium salt (PQQ) in Bulk? With people becoming more and more aware of the benefits of pyrroloquinoline quinone disodium salt (PQQ, the demand for pyrroloquinoline quinone disodium salt (PQQ) supplements has increased greatly in the market. This has led to manufacturing companies vying with each other to produce high-quality supplements to grab share in the market. If you are a health supplements manufacturer planning to foray into the pyrroloquinoline quinone disodium salt (PQQ) supplements market, you must ensure that you are getting the highest-quality pyrroloquinoline quinone disodium salt (PQQ) powder. Sourcing good-quality material is the first step in ensuring the success of any business. If you are looking for a place to buy pyrroloquinoline quinone disodium salt (PQQ) powder in bulk, the one company you can blindly trust for sourcing raw material is Cofttek. The company, owing to its strong research team and dedicated sales department, has established a worldwide presence in only a short amount of time — it has clients and partners around the world. The pyrroloquinoline quinone disodium salt (PQQ) produced by the company comes in big batches of 25 kgs and is sourced from highest-quality ingredients, thereby ensuring that the supplements produced from it can be trusted for quality and efficacy. If you want to buy pyrroloquinoline quinone disodium salt (PQQ) in bulk, the only place to shop is cofttek.com.

REFERENCES

[1]. "L-aminoadipate-semialdehyde dehydrogenase (Homo sapiens)". BRENDA. Technische Universität Braunschweig. July 2015. Retrieved 18 July 2015. [2]. "Pyrroloquinoline quinone (HMDB13636)". Human Metabolome Database. University of Alberta. Retrieved 19 July 2015. Enzymes containing PQQ are called quinoproteins. PQQ and quinoproteins play a role in the redox metabolism and structural integrity of cells and tissues PMID 2558842. It was reported that aminoadipate semialdehyde dehydrogenase (AASDH) might also use PQQ as a cofactor, suggesting a possibility that PQQ is a vitamin in mammals. PMID 12712191. [3]. Recent progress in studies on the health benefits of pyrroloquinoline quinone. Akagawa M, Nakano M, Ikemoto K.Biosci Biotechnol Biochem. 2016;80(1):13-22. doi: 10.1080/09168451.2015.1062715. Epub 2015 Jul 13.PMID: 26168402 
  1. Dekker RH, Duine JA, Frank J, Verwiel PE and Westerling J, 1982. Covalent addition of H2O, enzyme substrates and activators to pyrrolo‐quinoline quinone, the coenzyme of quinoproteins. European Journal of Biochemistry, 125, 69–73. - PubMed

  2. Duine JA and Jongejan JA, 1989. Quinoproteins, enzymes with pyrrolo‐quinoline quinone as cofactor. Annual Review of Biochemistry, 58, 403–426. - PubMed