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Alli weight loss drug being probed by FDA for liver damage threat BY The Associated Press Friday, August 28, 2009, 12:23 PM A A A facebook Tweet email Bates for News Alli, the only over-the-counter weight loss drug approved by the FDA, is now under investigation for causing liver damage. If you have been reading the UK newspapers or watching the news in the UK then you cannot fail to have heard of the Alli weight loss pill.
Originally available only by prescription (under the name of Xenical), Alli has been rebranded and tweaked slightly so that anyone can benefit from Alli. A BIG word of caution though, there are some very uncomfortable (and worryingly very common) side effects with Alli slimming tablets.
These side effects can range from stomach cramps and excess flatulence through to the much more worrying – chronic diarrhea. Of course, you can avoid these side-effects by careful management and only taking the tablet when you have had a high-fat meal. Before you buy Alli for weight loss we suggest you think carefully about whether you can handle the side-effects which are so commonly reported. Instead we much prefer Proactol diet pills which do exactly the same thing as Alli but without the side-effects.
Ultimately Alli does work if your main cause of excess weight is that you eat too many fatty meals. It is reported that for every 2lb you lose from eating healthily and exercising, Alli will help you to lose a further 1lb.
Overall Alli is being touted in the media as one of, if not THE best slimming tablet available. However, what you should remember is that a large proportion of these features in newspapers and on TV have been paid for by GSK – the company who make and sell Alli weight loss pills. The fact is that Alli does work but it has far too many bad side-effects to truly be considered as the number 1 weight loss tablet. Quite simply, there are much better alternatives that can provide the same, if not better, results without any known side effects. As we always say, the same pill never works for everyone so it is important to look at your own lifestyle and decide which slimming tablet is right for you.
However, if you do decide to give it a try then be prepared for the side effects which are all too commonly reported. Alli, the fat blocking weight loss pill, is now classed as a prescription medicine and can only be dispatched from a pharmacy or online pharmacy.
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Recently the FDA approved for the first time ever an over the counter diet pill to help people manage their weight. So far the alli diet pill does not seem to come with any major side effects but this is what the FDA had to say “the most common side effect of the product is a change in bowel habits, which may include loose stools. The early sales for the new weight loss diet pill has been booming with many national newspapers doing articles about the alli pills magnificent numbers. Glaxo Smith Klein the people behind the alli diet pill has finally given us a weight loss drug that is safe and effective.
When choosing a diet pill or supplement to aid your weight loss, it is important to find one that will produce the best results.
For those who are have a BMI of 28 and above, and are based in the UK, Alli may be a viable option, and is available at many pharmacies.
This review will compare Alli with XLS Medical by looking at the weight loss claims made, customer feedback, the price, as well as how each product works. The primary active ingredient of XLS Medical is the patented Litramine™, which is derived from dried prickly pear leaves. XLS Medical works by providing additional insoluble fibre that binds with dietary fat in the stomach. Litramine™ also provides additional soluble fibre, which, unlike insoluble fibre, is absorbed into the system. Orlistat, the active ingredient of Alli, affects the body on a chemical level, binding with and inhibiting enzymes in the stomach called gastrointestinal lipase.
The makers of Alli claim that it can prevent around 25% of fat from being absorbed by the body. The official website of XLS Medical cites several studies as clinical proof of the product’s effectiveness, and their statistics and claims are derived from these studies.
It is not clear in what context this claim is made, such as over what time period, for whom, and how this translates into actual pounds lost. It is likely that the claims listed above, especially XLS Medical’s claim that it causes 3 times as much weight loss as dieting alone, have raised customers’ expectations considerably. As well as these short term side effects, there are more long term and damaging side effects that have been linked with the use of Orlistat which are referred to in more detail below.
The undesirability of effects upon health that often occur in people who are obese may well outweigh any side effects that occur from taking Orlistat in an attempt to lose weight.
XLS Medical is derived from a natural plant source and so there should be very few side effects, especially compared to chemical based diet pills. It is recommended that to avoid some of these side effects, plenty of liquids are drunk as a part of a diet regime, and meals that are very high in fat are avoided or eaten only in moderation. Orlistat, and therefore Alli, have been very well researched, as evidenced by their approval by the FDA.
It is likely that Orlistat has more side effects than some other fat binders because it works on a chemical level, interfering with how the body works, rather than interacting with just the food that is consumed. The website also repeatedly mentions that Alli is for use alongside a healthy diet, to help to boost dieting efforts, and states that anyone not willing to make changes to their diet (to both aid weight loss and avoid nasty side effects) should most likely not take Alli. Orlistat has been associated with some long term side effects, such as an increased risk of kidney damage or liver damage. Unlike its more concentrated counterpart Xenical, Alli is not available on prescription, and so is not limited in price by the NHS. XLS Medical is available at a large variety of retailers, including Boots and Asda, as well as at online retailers such as Amazon.
When comparing Alli and XLS Medical, it is clear that both diet pills have their drawbacks.

However, there is significant evidence from clinical studies to suggest that both XLS Medical and Alli can contribute to weight loss efforts.
XLS Medical may have its limitations, and is an expensive product, but it is not a chemical based product and supposedly does not interfere with the actual workings of the body, whereas Orlistat based diet pills such as Alli have been linked with an increased change of long term side effects. It may be that neither product is ideal and that better weight loss products are available.
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Alli is a food supplement capsule that is designed to be taken as a means to preventing some of the fats in your food from being processed and absorbed into your body. Alli has been clinically trialled and tested to prove that by its inclusion in a reduced fat, calorie controlled diet, it actually can help to improve the amount of weight you can lose by anything up to 50 percent over the diet alone.
For the record, Alli is actually the first supplement for losing weight to be licensed in the European Union for sale in pharmacies.
When you visit some of the websites that promote Alli, they focus on the promotional information that says the supplement is intended for use by adults that are overweight and have a BMI (Body Mass Index) of 28 or more and desire to lose weight. If you are wondering, does Alli work as a weight loss pill, then it can under the right circumstances. How much depends on the individual, the diet and many other contributing factors that will vary from person to person. Launched at the start of summer 2009, Alli has hit the shelves of high-street stores – picking up a lot of publicity (bad and good) at the same time. The official line is that you should only buy it if you have a BMI of over 28 (you can check your body mass index with our BMI calculator), however as you can buy Alli online in truth it is available to anyone. Side effects of Alli include fatty smelly stools, urgency to get to the toilet (diarrhea), oily spotting on your underclothes, and excess wind. There are simply better, more natural slimming tablets available without the uncomfortable side effects.
Basically how it works is that when you have a meal that is high in fat, the active ingredient attaches itself to the fat in the food you consume.
If you miscalculate and the meal is not high enough in fat then you can and most probably will encounter some of the uncomfortable and embarrassing side effects. However, it is said to be very difficult to get it right everytime and far too easy to over-estimate how fatty a meal is.
However, it is not a complete weight loss solution as you will still need to go on a diet and exercise whilst using Alli. In other words it basically speeds up the rate of weight loss from the effort you put in to dieting and exercising. If you have to make sure you are losing weight anyway and Alli just speeds up the loss, we would much prefer to lose weight slightly slower but keep control of our bowel movements! It wouldn’t have been made available for sale on the high-street if this was not the case. Ultimately if you are eating a diet that is high in fat the Alli might be the best choice for you.
If the side effects do not appeal to you but you do fit in to the category of eating high-fat meals then Proactol diet pills are the best alternative product available with no known side effects. The alli diet pill which is a decreased strength version of the prescription drug Orlistat is only approved for over weight adults over the age of eighteen.
Eating a low fat diet will reduce the likelihood of this side effect.” It is also warned that people who have had organ transplants or being treated for diabetes should not take the over the counter pill. The alli program encourages modest, gradual weight loss, known by most as the best way to lose weight so no wonder people are rushing to go get it. Which product will do this depends upon a number of factors, including the user’s starting weight. But, how does this product compare to an unregulated weight loss solution, such as XLS Medical? Orlistat was approved by the Food and Drug Administration (FDA) in 1999, and is available only under prescription or at the discretion of a pharmacist.
XLS Medical also has added fat-soluble vitamins, which are intended to prevent a deficit of those vitamins, as their absorption is hindered by use of fat binding products. This fat-fibre complex becomes too large to pass through the walls of the small intestine, and so the altered fat passes through the body without being absorbed. This element of the product is not well advertised by XLS Medical, but may act as a further contributor towards weight loss. This type of enzyme is the one that usually interacts with dietary fats to break them down, so that they can be absorbed into the body for use or storage. In terms of how much weight loss this can cause, the official website for Alli estimates that for every 2 pounds lost by healthy eating, an extra pound will be lost by use of Alli, which is effectively a 50% boost in weight loss. XLS Medical claims to be able to bind up to 27% of dietary fats consumed in a meal, which prevents a significant number of consumed calories from being absorbed into the body. As these statistics are based on clinical trials that are performed using very specific circumstances, these claims should be viewed as the optimal performance, which is somewhat difficult to reproduce in day to day circumstances.
According to our estimations based upon the reliable customer reviews we found, around 40% of XLS Medical users appear to feel conned or ripped off because of their lack of results, especially when considering the expense of the product.
These potential side effects are a mixture of short term and long term, with prolonged damage to the body possible. Whilst this is not a decision to take lightly without personal research into the product, it may be that the Orlistat side effects are the lesser of two evils in many cases.
Despite claims that it is gentle on the system and doesn’t interfere with the “body’s natural workings”, reported side effects of XLS Medical include bloating, diarrhoea, constipation, headaches and even sickness.
This means that the side effects, or “diet related treatment effects” that can occur with its use are well documented. The official Alli website openly admits that misuse of the pills in combination with a diet high in fat will lead to unpleasant “diet related treatment effects” such as oily stools, wind with or without oily spotting and diarrhoea.
The website also offers tips on how to avoid any side effects, and explains the causes behind changed bowel movements in an easy to understand manner. These risks can be discussed in more detail with either a pharmacist or doctor, before a decision is made about whether or not to take Alli. The price for XLS medical varies immensely, with 180 tablets, which is a month’s supply, costing ?59.99 in Boots, although it can be found cheaper elsewhere. XLS Medical raises concerns because of the large number of customers who feel disappointed or ripped off, whereas Alli raises concerns because of the side effects associated with it, as its safety cannot be guaranteed.

Significant research should be conducted by the individual user before deciding to invest in either of these products, and both will produce more definitive results when combined with a healthy and balanced diet regime, as well as regular exercise. Further to this, those who are not obese but seeking to lose weight do not have the option of an Orlistat based diet pill available to them, making it a more limited product that XLS Medical, which is available over the counter and online. Further comparisons of these two diet pills can be made with a wider range of products available in the UK by going to our diet pills comparison page.
It essentially reduces the amount of fat that is stored in the body, leading to the prevention of weight gain and when combined together with a calorie controlled diet and support program, can lead to weight loss. When you work it out, it equates to losing an extra pound for every 2 pounds that you would lose by consuming a healthy, low calorie diet by using Alli as a supplement.
It is important to understand that eating sensibly and having a healthy diet are the major contributors to losing weight, while supplementing with a product such as Alli can help to improve the results.
According to the results from numerous trials, it does reduce the amount of fat the body stores from the food you consume. As a relatively inexpensive diet pill, this is one that is definitely worth trying as it is approved as safe and may be just what you are looking for in a weight loss diet supplement to help you to achieve your own goal. However, because they are produced by smaller companies without big advertising budgets, you may not have heard of them. To help cover running costs, some links to products may result in remuneration being paid to us if a visitor purchases a product. Orlistat is also available under the brand name of Xenical, which has a more concentrated dose, making it a prescription only product. Opuntia Ficus Indica, the plant that Litramine™ is derived from, has been clinically proven to lower blood cholesterol levels, and therefore reduce cardiovascular risk.
This means that fewer calories are taken into the body, which, when combined with a healthy balanced diet and exercise, leads to a calorie deficit, and weight loss.
With some of the enzyme in the stomach inhibited, less fat can be processed, and so less can be absorbed by the body. Alli is certainly not marketed to be a miracle weight loss pill, and without making any other changes to diet or activity level, users will most likely see only minor results. In addition to this, the makers of the pill make the dramatic claim that the use of XLS Medical causes three times as much weight loss as dieting alone. Results with fat binders will always be more prominent if use of the diet pills is combined with a balanced diet and exercise regime. However, it is important to point out that some users of the pill have reported good results, and others have reported some weight loss, even though they were disappointed with the time it took to lose the weight. The additional resources available such as the recipe book and online forum also seem to have a positive effect in helping users to stay motivated. However, Alli is only available from a pharmacist to those who meet the minimum BMI requirements of 28, which is well into the overweight category. The possible causes for these side effects are investigated fully elsewhere on dietpill-reviews in this article. These side effects can be serious, and are the reason that many users seem to consider Orlistat as a last resort to aid weight loss. It is the risk of these long term effects that make products containing Orlistat, such as Alli and Xenical, harder to recommend, despite the fact that ultimately as a product they do work. They are available in most pharmacies, such as Boots Pharmacy or Lloyd’s Pharmacy, and the price seems to range between ?35 and ?50 for a month’s supply.
This puts XLS medical amongst the more expensive diet pills available, especially considering that they only claim to hold one weight loss element, fat binding. The side effects of both diet pills can be minimised by following a reduced-fat diet plan and drinking plenty of water.
The information is intended for educational purposes only and does not constitute professional, medical or healthcare advice or diagnosis, and may not be used as such.
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The makers of the alli diet pill stress that the pill should be used in combination with a reduced calorie low fat diet. Orlistat has been tested in clinical trials extensively, and so its side effects are well documented, as well as having plenty of evidence to support its effectiveness. The claims that are made about Litramine™, and the clinical trials that support these claims, are discussed in more detail below. Fat is targeted (rather than developing a product that affects carbohydrates or protein) because it has the highest calorie density compared to other types of food. After this initial process, XLS Medical then releases fat soluble vitamins A, D3 and E-acetate, to prevent a deficiency in these, sometimes caused by this kind of diet pill. This then reduces the amount of calories taken in by the body, causing weight loss over a prolonged period of time.
However, there are some people who report very little weight loss, and a significant minority of users (around 9%) stop taking Alli because of continuing unpleasant side effects.
For those who are looking for an Orlistat based product who have a BMI of 30 or above, the cost of Alli may be offputting, especially as its sister product, Xenical, is available on prescription, which incurs a much smaller charge than ?35 a month. Alli seems to have more support in the form of diet plans, advice leaflets, and access to the Alli forum, where it is possible to interact with other Alli users to swap tips and advice, as well as to provide each other with encouragement and support.
Reviews featured on this website are researched and written by independent reviewers that are paid for their opinion and views.
Because it is slow acting and needs to be taken over a prolonged period, results may seem slow, but patients who take an Orlistat based product are more likely to maintain this weight loss after they stop taking the product.
She said alli's safety has been studied in more 30,000 patients enrolled in 100 clinical studies."Liver changes can have many causes," said Debbie Bolding, in a statement.
The key ingredient is chemically based, rather than being derived from any natural ingredient such as a plant. The information on this site is not reviewed by a medical professional, and is only to be used at your own risk.
This is where Orlistat differs from most other fat binders on the market, most of which are plant based and available over the counter.

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