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Patients with fibromyalgia syndrome (FMS) typically have widespread chronic pain and fatigue. In addition to pain and fatigue, individuals diagnosed with FMS may experience sleep disorders, morning stiffness, poor concentration, and occasionally mild-to-severe mental symptoms such as anxiety or depression. Calcifediol (also known as calcidiol, 25-hydroxycholecalciferol, or 25-hydroxyvitamin D (OH)D) is a prehormone produced in the liver by the enzyme cholecalciferol (vitamin D3). Researchers hypothesized that vitamin D supplementation would reduce the degree of chronic pain experienced by FMS patients with low levels of calcifediol and also might improve other symptoms. Twenty-four weeks after supplementation was stopped, a marked reduction in the level of perceived pain occurred in the treatment group.
Children in low and middle income countries should be given vitamin A supplements to prevent death and illness, concludes a study published online in the British Medical Journal.
The researchers argue that the effectiveness of vitamin A supplementation is now so well-established that further trials would be unethical, and they urge policymakers to provide supplements for all children at risk of deficiency. So a team of researchers based in the UK and Pakistan analysed the results of 43 trials of vitamin A supplementation involving over 200,000 children aged 6 months to 5 years.
They found vitamin A supplements reduced child mortality by 24% in low and middle income countries.
The authors say that, if the risk of death for 190 million vitamin A deficient children were reduced by 24%, over 600,000 lives would be saved each year and 20 million disability-adjusted life years (a measure of quantity and quality of life) would be gained.


Based on these results, the authors strongly recommend supplementation for children under 5 in areas at risk of vitamin A deficiency.
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For those with low vitamin D levels, vitamin D supplements can reduce pain and may be a cost-effective alternative or adjunct to other treatment, say researchers in the current issue of PAINĀ®.
Calcifediol is then converted to calcitriol (1,25-(OH)2D3), which is the active form of vitamin D. Between the first and the 25th week on supplementation, the treatment group improved significantly on a scale of physical role functioning, while the placebo group remained unchanged. Vitamin A deficiency in children increases vulnerability to infections like diarrhea and measles and may also lead to blindness. It may also reduce mortality and disability by preventing measles, diarrhea and vision problems, including night blindness. There is no cure, and no treatment will address all of the symptoms, but some symptoms may be alleviated by physical therapy, cognitive behavioral therapy, temporary drug therapy (such as amitriptyline, duloxetine, or pregabaline) and multimodal therapies. The concentration of calcifediol in blood is considered the best indicator of vitamin D status. But although the role of calcifediol in the perception of chronic pain is a widely discussed subject, we lack clear evidence of the role of vitamin D supplementation in fibromyalgia patients,” says lead investigator Florian Wepner, MD, of the Department of Orthopaedic Pain Management, Spine Unit, Orthopaedic Hospital, Speising, Vienna, Austria.


Serum calcifediol levels were reevaluated after five and 13 weeks, and the dose was reviewed based on the results.
Globally, the World Health Organisation estimates that 190 million children under the age of 5 may be vitamin A deficient. The calcifediol levels were measured again 25 weeks after the start of the supplementation, at which time treatment was discontinued, and after a further 24 weeks without supplementation. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE TREAT CURE OR PREVENT DISEASE.*These statements have not been evaluated by the FDA. But, despite widespread efforts, vitamin A programmes do not reach all children who could benefit. Deficiencies in vitamin D lead to rickets (improper bone formation) in children, and osteomalacia (bone softening) and osteoporosis (brittle bone disease) in adults.




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