Recent studies document that those veterans are at a particularly high risk for traumatic brain injury (TBI), post-traumatic stress disorder (PTSD), psychological nonepileptic seizures (PNES) and epileptic seizure diagnoses. According to a study by the VA’s Southeast Epilepsy Centers of Excellence and Duke University Medical Center in Durham, NC, 87,377 veterans with seizures diagnoses were managed within the VHA during fiscal year 2011. Veterans injured in Afghanistan and Iraq have high rates of co-morbid epilepsy, TBI and PTSD. The risks are especially great for those serving during Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF) and Operation New Dawn (OND), according to the research. Study authors note that, not only do veterans have high rates of epilepsy diagnoses overall, but “more young and female veterans are being diagnosed with epilepsy. That view was supported by another study presented at the American Epilepsy Society conference. Among patients with a definitive diagnosis of PNES, 63% of the subjects had PTSD alone, 50% had mTBI alone and 41.3% had a combination of the two, the Baylor researchers found. Susan Hayes, EEG Technician at the Durham, NC, VA Medical Center, sets an unidentified patient up for an EEG. After reviewing all patients meeting criteria for PNES at the Portland VAMC from 2000-2011, the researchers found that the majority of veterans continued to report seizures even after three years of follow-up.
The study also determined that more than 80% of PNES patients received anti-epileptic drugs (AEDs) for seizures prior to EMU evaluation but were able to remain continuously off the drugs through 36 months of follow-up.
A fourth study, meanwhile, determined that an algorithm validated for identifying epilepsy in geriatric patients was not appropriate for making the diagnosis in the general population.
ECoE researchers looked at administrative databases and defined epilepsy as patients having a seizure diagnosis on at least one encounter and prescribed at least one AED during the same fiscal year. 5.    With Research, There Is Hope – While there have been significant scientific discoveries in our understanding of the disease, much more needs to be done. Following agreement with 16 funding organisations in Austria, Belgium (FWO and FNRS), Estonia, Finland, Germany, Hungary, Luxemburg, Norway, Poland, Portugal, Romania, Spain, Switzerland, Turkey and the United Kingdom, the European Science Foundation launched a Call for Full Proposals for Collaborative Research Projects (CRPs) to be undertaken within the EUROCORES Programme EuroEPINOMICS.
The programme will run for 3 years (April 2011 – April 2014) and aims to support high quality multidisciplinary research in Europe, with involvement of leading scientists from outside Europe when appropriate. A review by the American Academy of Neurology of available scientific research on the use of medical marijuana in brain diseases finds certain forms of medical marijuana can help treat some symptoms of multiple sclerosis (MS), but do not appear to be helpful in treating drug-induced (levodopa) movements in Parkinson’s disease.
The AAN review concluded that certain forms of medical marijuana (only in pill or oral spray form) can help treat some symptoms of MS. For Parkinson’s disease, the AAN review concluded that medical marijuana in the form of synthetic tetrahydrocannabinol (THC) pills likely does not help relieve abnormal movements that can develop in the late stages of the disease from the drug levodopa, which is the main drug used to treat shaking, stiffness and slowness of movements.
Mood changes and suicidal thoughts are of special concern for people with MS, who are at an increased risk for depression or suicide. In general, medical marijuana is prescribed as a treatment for use only when standard treatment has not helped. EpilepsyU has all the features that you would expect from an epilepsy website and more, like the latest epilepsy and neurology news, a blogging platform and community groups, friends, and a News Feed, just like Facebook and more! EpilepsyU has dynamic content, like LIVE interactive Webinars, and a backlog of recordings from past webinars.


EpilepsyU is a community run by the Epilepsy Association of Central Florida and partially funded by the Florida Department of Health. They also determined that 90.6% of subjects with PTSD who received definitive VEEG diagnoses also had PNES.
This is one of the procedures used at the VA Southeast Epilepsy Center of Excellence to diagnose epilepsy. When epilepsy specialists at three ECoE sites in Durham, Miami and Tampa, FL, used that criteria to review electronic charts of 527 FY10 patients who were not captured in FY11, 308 were confirmed to have epilepsy.
Researchers urged better diagnosis and more access to specialty care to remedy that discrepancy. Validation of an Algorithm for the Identification of Epilepsy Patients in the Veterans Health Administration (VHA) (Abst.
Even when there are early signs and symptoms, they may be vague and easily attributed to another disease. Of those diagnosed with pancreatic cancer, just six percent survive five years and most with advanced cancer die within a year.
Since it was founded in 1998, The Lustgarten Foundation has played an important role in the evolution of the field of pancreatic cancer research, devoting more than $42 million to more than 125 research projects at more than 40 medical and research centers worldwide.
Research offers hope for an early detection test, more effective long-term treatments and – ultimately – a cure.
You hear the phrase precision medicine quite frequently these days and might wonder what this is all about. What are the quality criteria that you should apply to a case report that claims to successfully use genetic information for treatment choices?
The genetic alteration found in the patient needs to be causative according to established diagnostic criteria. Not enough evidence was found to show if medical marijuana is helpful in treating motor problems in Huntington’s disease, tics in Tourette syndrome, cervical dystonia and seizures in epilepsy. These include spasticity, certain types of pain (pain related to spasticity, including painful spasms, and painful burning and numbness) and overactive bladder.
Side effects reported in at least two studies were nausea, increased weakness, behavioral or mood changes, suicidal thoughts or hallucinations, dizziness or fainting symptoms, fatigue, and feelings of intoxication.
The studies showed the risk of serious psychological effects is about 1 percent, or one in every 100 people. Our content is provided by many sources and universities, and our team scours the globe for the latest and most important epilepsy news.
Brad Vineyard is prepped by Marty Litchfield, a physician assistant at Fort Campbell’s traumatic brain injury clinic, for a quantitative electroencephalograms brain mapping in 2011.
For example, potential symptoms may include fatigue, back pain, abdominal pain, unexplained weight loss, loss of appetite, jaundice, nausea and inflammation of the pancreas.
And, 100 percent of every dollar raised by The Lustgarten Foundation goes directly to research due to Cablevision’s support of the Foundation.
In a nutshell, in the context of genetic epilepsies, the basic idea behind precision medicine is to use genetic patient information for treatment decisions.


In the case of the study by Pierson and collaborators, the authors managed to model the mutation in vitro, which allowed them to test various compounds. All I wanted to do in this post is raise the issue that there are at least three components to consider when assessing case reports of precision medicine in patients with genetic epilepsies. The review is published in the April 29, 2014, print issue ofNeurology®, the medical journal of the American Academy of Neurology (AAN), and will be presented at the AAN Annual Meeting in Philadelphia, April 26-May 3, 2014, which is the world’s largest gathering of neurologists.
However, the studies did not provide enough information to show if smoked medical marijuana is effective. The broader vision behind this aims at improving the lives of individuals with epilepsy by making smarter and faster treatment decisions, which lead to better treatment response and fewer side effects. These include (A) the causative nature of the mutation, (B) the reasoning of the choice of treatment and perhaps most importantly (C) the appropriate measure of the patient-related effect or outcome. If novel genes or genes of uncertain significant are affected, we should take into account that the variant, which all further investigations are based upon, may in fact not be causative.
The treatment choice needs to be specific to the genetic alteration – deciding to use a antiepileptic drug may well result in a broad non-specific effect that is unrelated to the underlying mutation, suggesting a specific effect that is simply not there.
Is it possible that the authors only observed random fluctuation of a self-limiting epilepsy rather than a real effect of the treatment? It might be worthwhile establishing a generally accepted framework that we can use to evaluate such information. Speaking of Facebook, registering for EpilepsyU with a Facebook account is just one click away! I acknowledge that there might be modifiers that could play a particular role in the context of precision medicine, but we are not at the point yet to reliably pinpoint their role. In many cases, replicating the particular mutation or gene effect in a model system might not be possible – if we chose any particular treatment based on the genetic finding, we need to be aware that our reasoning might be insufficient. Finally, there is invariably a publication bias as only positive and successful reports are published. For example, one example was a recent publication by Pierson and collaborators, which (A) identified a GRIN2A de novo mutation in a patient with epileptic encephalopathy, (B) showed in vitro that memantine restores some of the aberrant channel function and used this for patient treatment. This may then further into prominence an association which may have been arisen purely due to chance.
For example, the positive effect of lamotrigine in patients with SCN2A encephalopathy has been discussed widely – however, this only applied to a few patients reported by Nakamura and colleagues. In addition to systematic studies like this, there are various retrospective reports on positive responses to medications in patients, in which a genetic cause was identified through massive parallel sequencing technologies.
These examples include lamotrigine in SCN2A encephalopathy or pyridoxine in congenital disorders of glycosylation (CDG).



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